Functional Roles of Fatty Acids and Their Effects on Human Health

Journal of Parenteral and Enteral Nutrition - Tập 39 Số 1S - 2015
Philip C. Calder1
1Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom National Institute of Health Research Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton General Hospital, Southampton, United Kingdom Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia [email protected].

Tóm tắt

A variety of fatty acids exists in the diet of humans, in the bloodstream of humans, and in cells and tissues of humans. Fatty acids are energy sources and membrane constituents. They have biological activities that act to influence cell and tissue metabolism, function, and responsiveness to hormonal and other signals. The biological activities may be grouped as regulation of membrane structure and function; regulation of intracellular signaling pathways, transcription factor activity, and gene expression; and regulation of the production of bioactive lipid mediators. Through these effects, fatty acids influence health, well‐being, and disease risk. The effects of saturated, cis monounsaturated, ω‐6 and ω‐3 polyunsaturated, and trans fatty acids are discussed. Although traditionally most interest in the health impact of fatty acids related to cardiovascular disease, it is now clear that fatty acids influence a range of other diseases, including metabolic diseases such as type 2 diabetes, inflammatory diseases, and cancer. Scientists, regulators, and communicators have described the biological effects and the health impacts of fatty acids according to fatty acid class. However, it is now obvious that within any fatty acid class, different members have different actions and effects. Thus, it would seem more appropriate to describe biological effects and health impacts of individual named fatty acids, although it is recognized that this would be a challenge when communicating outside of an academic environment (eg, to consumers).

Từ khóa


Tài liệu tham khảo

Simons K, 2010, Revitalizing membrane rafts: new tools and insights, Nat Rev Mol Cell Biol, 11L688

10.1146/annurev.bi.63.070194.004253

10.1194/jlr.R600007-JLR200

10.1016/j.cell.2004.11.043

10.1055/s-0033-1358523

10.3109/10409231003667500

10.1146/annurev.nutr.19.1.63

10.1074/jbc.M011695200

10.1161/ATVBAHA.109.188813

10.1074/jbc.M109.044065

10.1161/ATVBAHA.109.194050

10.1016/j.cmet.2012.01.023

10.1161/01.ATV.12.8.911

10.1093/ajcn/77.5.1146

10.1097/MCO.0b013e3282f52708

10.1007/s001250051620

10.3945/ajcn.2009.29096

10.1038/ijo.2010.209

10.1016/S2213-8587(14)70146-9

10.2337/diacare.26.5.1362

10.1093/ajcn/82.6.1178

10.1093/ajcn/79.6.969

10.1371/journal.pmed.1001255

10.3945/ajcn.2009.27725

10.7326/M13-1788

10.3945/ajcn.2008.27124

10.1161/01.ATV.12.4.529

10.1038/sj.ejcn.1601477

10.2174/138161211795428957

10.2174/138161211795428948

10.3390/nu1020133

10.1186/1476-511X-13-154

10.1056/NEJMoa1200303

10.1016/j.cell.2008.07.048

10.1371/journal.pone.0039286

10.1001/archinte.160.8.1154

10.1093/jn/133.4.1060

10.2337/dc09-0544

10.1093/ajcn/78.1.91

10.3945/ajcn.110.006643

10.1016/j.bbalip.2013.08.011

10.1016/S0955-2863(02)00174-2

10.1271/bbb.64.1111

10.1016/S0022-2275(20)41618-9

10.1017/S0007114510002096

10.1016/j.plipres.2008.10.002

10.1177/2042018810375656

10.1093/ajcn/63.3.322

10.1161/01.CIR.0000079224.46084.C2

10.1017/S0007114507871674

10.1017/S0007114510004010

10.1371/journal.pmed.1000252

10.1006/bbrc.1996.1857

10.1189/jlb.3RU0115-021R

10.1016/j.bbalip.2014.08.010

10.1006/bbrc.2001.6155

10.1046/j.1365-2362.2000.00623.x

10.1093/jn/131.7.1918

10.1016/S0021-9150(02)00067-9

10.1210/jc.2005-1303

10.1093/brain/116.3.717

10.1093/ajcn/60.2.189

Crawford MA, 1976, The long chain metabolites of linoleic and linolenic acids in liver and brain in herbivores and carnivores, Comp Biochem Physiol, 54, 395

10.1002/ejlt.201400025

10.1074/jbc.M404376200

10.3945/jn.111.155259

10.1152/ajplung.00077.2002

10.1073/pnas.89.10.4653

10.1210/mend.11.6.0007

10.1097/00041433-200402000-00004

10.1097/00075197-200403000-00008

10.1097/00041433-200204000-00007

10.1097/MOL.0b013e3282ffaf6a

10.1093/ajcn/83.6.1520S

10.1016/j.cell.2010.07.041

10.1007/s11745-006-1155-0

10.1016/S0278-5846(01)00254-8

10.1097/JCP.0b013e3182485791

10.1016/j.clinbiochem.2008.05.013

10.1177/0883073811435243

10.1016/j.nut.2011.12.009

10.1111/j.1651-2227.2010.01871.x

10.1093/pch/14.2.89

10.1186/1475-2891-6-16

10.1016/S0924-977X(03)00032-4

10.1001/archpsyc.56.5.407

10.1176/appi.ajp.159.3.477

10.1016/S0920-9964(00)00083-9

10.1001/archpsyc.59.10.913

10.1176/appi.ajp.158.12.2071

10.1172/JCI118507

10.1080/10284150290007119

10.1016/j.bbalip.2011.10.011

10.1007/BF02529870

Harris WS, 1997, n‐3 Fatty acids and serum lipoproteins: human studies, Am J Clin Nutr, 65, 1645S, 10.1093/ajcn/65.5.1645S

10.1016/j.atherosclerosis.2006.02.012

10.1093/ajcn/71.5.1085

10.1093/ajcn/76.5.1007

10.1016/S0022-2275(20)39881-3

10.2337/diacare.26.1.253

10.3945/jn.110.130021

10.1001/archinte.1993.00410120017003

10.1161/01.CIR.88.2.523

10.1097/00004872-200208000-00010

Balk E, 2004, Effects of omega‐3 fatty acids on cardiovascular risk factors and intermediate markers of cardiovascular disease, Evid Rep Technol Assess (Summ), 93, 1

10.1007/s00125-006-0486-y

10.1093/ajh/hpu024

10.1017/S0007114511005460

10.3945/ajcn.112.037432

10.2337/db12-1042

10.1017/S0007114512001560

10.2174/138161282006140220125732

10.1016/j.jpeds.2008.09.014

10.3945/ajcn.113.081208

10.1161/01.CIR.0000038493.65177.94

LondonB AlbertC AndersonMet al.Omega‐3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart Lung and Blood Institute and Office of Dietary Supplements Omega‐3 Fatty Acids and Their Role in Cardiac Arrhythmogenesis Workshop. Circulation.2007;116:e320‐e335.

10.1093/ajcn/84.1.5

10.1042/CS20040119

10.1016/S0140-6736(10)60445-X

10.1056/NEJMra1008153

10.1016/S0140-6736(89)90828-3

10.1016/S0140-6736(99)07072-5

10.1161/01.CIR.0000014682.14181.F2

10.1016/S0140-6736(07)60527-3

10.1016/S0140-6736(08)61239-8

10.1016/S0002-9343(01)01114-7

10.1001/archinte.165.7.725

Leon H, 2009, Effect of fish oil on arrhythmias and mortality: systematic review, BMJ, 338, a2931

10.1136/bmj.c6273

10.1056/NEJMoa1003603

10.1161/CIRCULATIONAHA.110.948562

10.1056/NEJMoa1205409

10.1056/NEJMoa1203859

10.1001/archinternmed.2012.262

10.1161/CIRCOUTCOMES.112.966168

10.1001/2012.jama.11374

10.1016/S1567-5688(13)70005-9

10.1016/j.numecd.2013.12.004

10.1016/j.atherosclerosis.2007.11.008

10.3945/ajcn.112.049833

10.1007/s00232-001-0095-0

10.1172/JCI112147

10.1016/S0140-6736(03)12468-3

10.1016/j.atherosclerosis.2010.05.022

10.1016/j.yexcr.2010.02.039

10.1155/2013/310186

10.1038/nrc2809

10.1038/bjc.2012.586

Gerber M., 2012, Omega‐3 fatty acids and cancers: a systematic update review of epidemiological studies, Br J Nutr, 107, S2228

10.1146/annurev-nutr-112912-095300

Elia M, 2006, Enteral (oral or tube administration) nutritional support and eicosapentaenoic acid in patients with cancer: a systematic review, Int J Oncol, 28, 5

10.1200/JCO.2011.36.4109

10.1080/01635580701365068

10.1038/ejcn.2011.214

10.1016/j.clnu.2009.11.004

10.1002/cncr.25933

10.1016/j.ccr.2011.08.010

10.1001/jamaoncol.2015.0388

10.1002/hed.21580

10.1002/cncr.25709

10.1200/JCO.2005.04.5724

Guarcello M, 2007, EPA‐enriched oral nutritional support in patients with lung cancer: effects on nutritional status and quality of life, Nutr Ther Metab, 25, 25

10.1079/NRR2005113

10.1007/BF02536235

10.1093/ajcn/84.1.44

10.1093/ajcn/77.4.783

Arterburn LM, 2006, Distribution, interconversion, and dose response of n‐3 fatty acids in humans, Am J Clin Nutr, 83, 1467S, 10.1093/ajcn/83.6.1467S

10.3945/jn.108.103861

10.1093/jn/134.11.2991

10.1093/ajcn/63.1.116

10.3945/ajcn.112.044040

10.1016/j.plipres.2010.07.004

10.1093/ajcn/61.3.617

10.1017/S0007114514002578

10.1093/ajcn/80.3.614

10.1093/jn/135.3.562

10.1016/0140-6736(93)90350-P

10.1161/JAHA.114.000914

Thông tin
Thông tin xuất bản

Journal of Parenteral and Enteral Nutrition

Tập 39 Số 1S

Thông tin tác giả