Functional Consequences of Morphological Neuroglial Changes in the Magnocellular Nuclei of the Hypothalamus

Journal of Neuroendocrinology - Tập 14 Số 3 - Trang 241-246 - 2002
Stéphane H. R. Oliet1
1Inserm U378 and Université Victor Segalen, Bordeaux, Bordeaux, France.

Tóm tắt

AbstractThe supraoptic and paraventricular nuclei of the hypothalamus undergo reversible anatomical changes under conditions of intense neurohypophysial hormone secretion, such as lactation, parturition and chronic dehydration. This morphological remodelling includes a reduction in astrocytic coverage of neurones resulting in an increase in the number and extent of directly juxtaposed somatic and dendritic surfaces. There is a growing body of evidence indicating that such anatomical plasticity is of functional significance. Astrocytic‐dependent clearance of electrolytes and neurotransmitters from the extracellular space appears to be altered under conditions where glial coverage of magnocellular neurones is reduced. Glutamate, for example, has been found to accumulate in the extracellular space in the supraoptic nucleus of lactating animals and cause a modulation of synaptic efficacy. On the other hand, the range of action of substances released from astrocytes and acting on adjacent magnocellular neurones is expected to be limited during such anatomical remodelling. It thus appears that the structural plasticity of the magnocellular nuclei does affect neuroglial interactions, inducing significant changes in signal transmission and processing.

Từ khóa


Tài liệu tham khảo

10.1152/physrev.1991.71.2.331

10.1046/j.1365-2826.1998.00279.x

10.1016/0306-4522(93)90002-W

10.1146/annurev.neuro.20.1.375

10.1139/o00-023

10.1016/0306-4522(82)90044-6

10.1016/S0149-7634(99)00080-9

10.1016/S0896-6273(00)80086-0

10.1523/JNEUROSCI.18-19-07709.1998

10.1016/S0166-2236(96)10024-2

10.1038/385630a0

10.1016/S0896-6273(00)80566-8

10.1016/S0166-2236(96)20050-5

10.1111/j.1469-7793.2000.t01-1-00109.x

10.1016/S0896-6273(00)80401-8

10.1126/science.1059162

10.1523/JNEUROSCI.18-17-06641.1998

10.1677/joe.0.1160225

10.1210/endo-124-5-2358

10.1016/0006-8993(94)90809-5

10.1152/jn.1997.77.2.527

10.1038/35006649

10.1016/0197-0186(95)00158-1

10.1111/j.1469-7793.1997.113bf.x

10.1152/jn.1992.67.6.1698

10.1111/j.1471-4159.1982.tb04702.x

10.1113/jphysiol.1991.sp018672

10.1016/S0166-2236(98)01349-6

10.1152/physrev.1992.72.1.101

10.1002/cne.903540103

Martin DL, 1990, The role of osmotic pressure and membrane potential in K+‐stimulated taurine release from cultured astrocytes and LRM55 cells, J Neurosci, 10, 571, 10.1523/JNEUROSCI.10-02-00571.1990

10.1111/j.1469-7793.1997.609bj.x

10.1016/S0896-6273(00)80971-X

10.1073/pnas.050424697

10.1113/jphysiol.1994.sp020249

10.1523/JNEUROSCI.20-15-05813.2000

10.1042/bj2840491

10.1113/jphysiol.1986.sp016192

10.1016/0306-4522(80)90063-9

Thông tin
Thông tin xuất bản

Journal of Neuroendocrinology

Tập 14 Số 3

241-246

Thông tin tác giả