Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

American Association for the Advancement of Science (AAAS) - Tập 356 Số 6335 - Trang 307-311 - 2017
Thomas J. Park1, Jane Reznick2, Bethany L. Peterson1, Gregory Blass1, Damir Omerbašić2, Nigel C. Bennett3, P. Henning J. L. Kuich4, Christin Zasada4, Brigitte Browe1, Wiebke Hamann5, Daniel T. Applegate1, Michaël Radkë6,5, Tetiana Kosten2, Heike Lutermann3, Victoria Gavaghan1, Ole Eigenbrod2, Valérie Bégay2, Vince G. Amoroso1, Vidya Govind1, Richard D. Minshall7, Ewan St. John Smith8, John Larson9, Michael Gotthardt6,5, Stefan Kempa4, Gary R. Lewin10,2
1Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
2Molecular Physiology of Somatic Sensation, Max Delbrück Center for Molecular Medicine, Berlin, Germany
3Department of Zoology and Entomology, University of Pretoria, Pretoria, Republic of South Africa
4Integrative Proteomics and Metabolomics, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
5Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany
6German Centre for Cardiovascular Research (DZHK), Berlin, Germany
7Departments of Anesthesiology and Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA.
8Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, UK
9Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.
10Excellence Cluster NeuroCure, Charité, Universitätsmedizin Berlin, Berlin, Germany

Tóm tắt

Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia. Science , this issue p. 307 ; see also p. 248

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American Association for the Advancement of Science (AAAS)

Tập 356 Số 6335

307-311

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