Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance

Current Opinion in Lipidology - Tập 19 Số 1 - Trang 16-24 - 2008
Kimber L. Stanhope1, Peter J. Havel
1Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis California 95616, USA

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Bizeau, 2005, Hepatic adaptations to sucrose and fructose, Metabolism, 54, 1189, 10.1016/j.metabol.2005.04.004

Elliott, 2002, Fructose, weight gain, and the insulin resistance syndrome, Am J Clin Nutr, 76, 911, 10.1093/ajcn/76.5.911

Havel, 2005, Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism, Nutr Rev, 63, 133, 10.1111/j.1753-4887.2005.tb00132.x

Le, 2006, Metabolic effects of fructose, Curr Opin Clin Nutr Metab Care, 9, 469, 10.1097/01.mco.0000232910.61612.4d

Wei, 2007, Fructose-mediated stress signaling in the liver: implications for hepatic insulin resistance, J Nutr Biochem, 18, 1, 10.1016/j.jnutbio.2006.03.013

Rutledge, 2007, Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms, Nutr Rev, 65, S13, 10.1301/nr.2007.jun.S13-S23

Havel, 2003, Short-term and long-term consumption of high fructose, but not high glucose, diets increases postprandial triglycerides and apo-lipoprotein-B in women, J Invest Med, 51, S163

Teff, 2004, Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women, J Clin Endocrinol Metab, 89, 2963, 10.1210/jc.2003-031855

Teff, 2005, Fructose-sweetened beverages decrease circulating leptin levels and increase postprandial triglycerides in obese men and women, Diabetes, 54, A385

Mayes, 1993, Intermediary metabolism of fructose, Am J Clin Nutr, 58, 754S, 10.1093/ajcn/58.5.754S

Matsuzaka, 2004, Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice, Diabetes, 53, 560, 10.2337/diabetes.53.3.560

Nagai, 2002, Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha, Am J Physiol Endocrinol Metab, 282, E1180, 10.1152/ajpendo.00471.2001

Lewis, 1997, Fatty acid regulation of very low density lipoprotein production, Curr Opin Lipidol, 8, 146, 10.1097/00041433-199706000-00004

Olofsson, 2005, Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis, J Intern Med, 258, 395, 10.1111/j.1365-2796.2005.01556.x

Chong, 2007, Mechanisms for the acute effect of fructose on postprandial lipemia, Am J Clin Nutr, 85, 1511, 10.1093/ajcn/85.6.1511

Vedala, 2006, Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans, J Lipid Res, 47, 2562, 10.1194/jlr.M600200-JLR200

Donnelly, 2005, Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease, J Clin Invest, 115, 1343, 10.1172/JCI23621

Hudgins, 2000, Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects, J Lipid Res, 41, 595, 10.1016/S0022-2275(20)32407-X

Timlin, 2005, Temporal pattern of de novo lipogenesis in the postprandial state in healthy men, Am J Clin Nutr, 81, 35, 10.1093/ajcn/81.1.35

Votruba, 2007, Regional fat deposition as a factor in FFA metabolism, Annu Rev Nutr, 27, 149, 10.1146/annurev.nutr.27.061406.093754

Marin, 1990, Uptake of triglyceride fatty acids in adipose tissue in vivo in man, Eur J Clin Invest, 20, 158, 10.1111/j.1365-2362.1990.tb02263.x

Romanski, 2000, Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans, Am J Physiol Endocrinol Metab, 279, E455, 10.1152/ajpendo.2000.279.2.E455

Jensen, 2003, Regional uptake of meal fatty acids in humans, Am J Physiol Endocrinol Metab, 285, E1282, 10.1152/ajpendo.00220.2003

Marin, 1992, The morphology and metabolism of intraabdominal adipose tissue in men, Metabolism, 41, 1242, 10.1016/0026-0495(92)90016-4

Bickerton, 2007, Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period, Diabetes, 56, 168, 10.2337/db06-0822

Abate, 1995, Relationships of generalized and regional adiposity to insulin sensitivity in men, J Clin Invest, 96, 88, 10.1172/JCI118083

Bjorntorp, 1992, Regional fat distribution: implications for type II diabetes, Int J Obes Relat Metab Disord, 16, S19

Goodpaster, 1999, Effects of weight loss on regional fat distribution and insulin sensitivity in obesity, Diabetes, 48, 839, 10.2337/diabetes.48.4.839

Kissebah, 1982, Relation of body fat distribution to metabolic complications of obesity, J Clin Endocrinol Metab, 54, 254, 10.1210/jcem-54-2-254

Pouliot, 1992, Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels, Diabetes, 41, 826, 10.2337/diab.41.7.826

Vague, 1956, The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease, Am J Clin Nutr, 4, 20, 10.1093/ajcn/4.1.20

Bergman, 2001, Central role of the adipocyte in the metabolic syndrome, J Investig Med, 49, 119, 10.2310/6650.2001.34108

Bjorntorp, 1990, Obesity and adipose tissue distribution as risk factors for the development of disease. A review, Infusionstherapie, 17, 24

Montague, 2000, The perils of portliness: causes and consequences of visceral adiposity, Diabetes, 49, 883, 10.2337/diabetes.49.6.883

Arner, 1990, Beta-adrenoceptor expression in human fat cells from different regions, J Clin Invest, 86, 1595, 10.1172/JCI114880

Engfeldt, 1988, Lipolysis in human adipocytes, effects of cell size, age and of regional differences, Horm Metab Res Suppl, 19, 26

Bolinder, 1983, Differences at the receptor and postreceptor levels between human omental and subcutaneous adipose tissue in the action of insulin on lipolysis, Diabetes, 32, 117, 10.2337/diab.32.2.117

Mittelman, 2002, Extreme insulin resistance of the central adipose depot in vivo, Diabetes, 51, 755, 10.2337/diabetes.51.3.755

Foley, 1980, Insulin binding and hexose transport in rat adipocytes. Relation to cell size, Diabetologia, 19, 234, 10.1007/BF00275275

Franck, 2007, Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual, Diabetologia, 50, 1716, 10.1007/s00125-007-0713-1

Karnieli, 1986, Distribution of glucose transporters in membrane fractions isolated from human adipose cells. Relation to cell size, J Clin Invest, 78, 1051, 10.1172/JCI112660

Olefsky, 1977, Insensitivity of large rat adipocytes to the antilipolytic effects of insulin, J Lipid Res, 18, 459, 10.1016/S0022-2275(20)41662-1

Olefsky, 1977, Mechanisms of decreased insulin responsiveness of large adipocytes, Endocrinology, 100, 1169, 10.1210/endo-100-4-1169

Havel, 2004, Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism, Diabetes, 53, S143, 10.2337/diabetes.53.2007.S143

Koutsari, 2006, Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity, J Lipid Res, 47, 1643, 10.1194/jlr.R600011-JLR200

Nielsen, 2004, Splanchnic lipolysis in human obesity, J Clin Invest, 113, 1582, 10.1172/JCI21047

Havel, 1970, Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans, J Clin Invest, 49, 2017, 10.1172/JCI106422

Soler-Argilaga, 1974, Lipid metabolism of rat liver isolated and perfused in hypoxia, Biomedicine, 20, 154

Wahren, 1984, Turnover and splanchnic metabolism of free fatty acids and ketones in insulin-dependent diabetics at rest and in response to exercise, J Clin Invest, 73, 1367, 10.1172/JCI111340

Gibbons, 2000, Mobilisation of triacylglycerol stores, Biochim Biophys Acta, 1483, 37, 10.1016/S1388-1981(99)00182-1

Nakao, 2002, Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults, Am J Gastroenterol, 97, 1796, 10.1111/j.1572-0241.2002.05846.x

Marceau, 1999, Liver pathology and the metabolic syndrome X in severe obesity, J Clin Endocrinol Metab, 84, 1513, 10.1210/jcem.84.5.5661

Marchesini, 2001, Nonalcoholic fatty liver disease: a feature of the metabolic syndrome, Diabetes, 50, 1844, 10.2337/diabetes.50.8.1844

Marchesini, 1999, Association of nonalcoholic fatty liver disease with insulin resistance, Am J Med, 107, 450, 10.1016/S0002-9343(99)00271-5

Ryysy, 2000, Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients, Diabetes, 49, 749, 10.2337/diabetes.49.5.749

Tiikkainen, 2002, Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes, Obes Res, 10, 859, 10.1038/oby.2002.118

Seppala-Lindroos, 2002, Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men, J Clin Endocrinol Metab, 87, 3023, 10.1210/jcem.87.7.8638

Morino, 2006, Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction, Diabetes, 55, S9, 10.2337/db06-S002

Samuel, 2004, Mechanism of hepatic insulin resistance in nonalcoholic fatty liver disease, J Biol Chem, 279, 32345, 10.1074/jbc.M313478200

Newton, 2003, Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm, Biochem J, 370, 361, 10.1042/bj20021626

Itani, 2002, Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha, Diabetes, 51, 2005, 10.2337/diabetes.51.7.2005

Yu, 2002, Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle, J Biol Chem, 277, 50230, 10.1074/jbc.M200958200

Dey, 2006, Involvement of novel PKC isoforms in FFA induced defects in insulin signaling, Mol Cell Endocrinol, 246, 60, 10.1016/j.mce.2005.12.014

Greene, 2004, Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta, Biochem J, 378, 105, 10.1042/bj20031493

Kellerer, 1997, Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells, FEBS Lett, 418, 119, 10.1016/S0014-5793(97)01357-4

Braiman, 2001, Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle, Mol Endocrinol, 15, 565

Strack, 1997, Impact of mutations at different serine residues on the tyrosine kinase activity of the insulin receptor, Biochem Biophys Res Commun, 239, 235, 10.1006/bbrc.1997.7457

Gao, 2004, Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes, Mol Endocrinol, 18, 2024, 10.1210/me.2003-0383

Horton, 2002, SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver, J Clin Invest, 109, 1125, 10.1172/JCI0215593

Shimomura, 2000, Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice, Mol Cell, 6, 77, 10.1016/S1097-2765(05)00010-9

Lewis, 1993, Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals, Diabetes, 42, 833, 10.2337/diab.42.6.833

Brown, 2001, Insulin inhibits the maturation phase of VLDL assembly via a phosphoinositide 3-kinase-mediated event, Arterioscler Thromb Vasc Biol, 21, 1656, 10.1161/hq1001.096640

Taghibiglou, 2002, Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance, J Biol Chem, 277, 793, 10.1074/jbc.M106737200

Lin, 1995, Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression, J Lipid Res, 36, 1073, 10.1016/S0022-2275(20)39865-5

Hussain, 2003, Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly, J Lipid Res, 44, 22, 10.1194/jlr.R200014-JLR200

Lewis, 2002, Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes, Endocr Rev, 23, 201, 10.1210/edrv.23.2.0461

Brunzell, 1973, Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man, J Clin Invest, 52, 1578, 10.1172/JCI107334

Havel, 1960, Idiopathic hyperlipemia: metabolic studies in an affected family, J Clin Invest, 39, 1777, 10.1172/JCI104202

Eckel, 1995, Alterations in lipoprotein lipase in insulin resistance, Int J Obes Relat Metab Disord, 19, S16

Bansal, 2007, Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women, JAMA, 298, 309, 10.1001/jama.298.3.309

Hyson, 2003, Postprandial lipemia and cardiovascular disease, Curr Atheroscler Rep, 5, 437, 10.1007/s11883-003-0033-y

Karpe, 1999, Postprandial lipoprotein metabolism and atherosclerosis, J Intern Med, 246, 341, 10.1046/j.1365-2796.1999.00548.x

Lopez-Miranda, 2006, Postprandial lipoprotein metabolism, genes and risk of cardiovascular disease, Curr Opin Lipidol, 17, 132, 10.1097/01.mol.0000217894.85370.c2

Nordestgaard, 2007, Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women, JAMA, 298, 299, 10.1001/jama.298.3.299

Berneis, 2002, Metabolic origins and clinical significance of LDL heterogeneity, J Lipid Res, 43, 1363, 10.1194/jlr.R200004-JLR200

Marcovina, 2006, Measurement and meaning of apolipoprotein AI and apolipoprotein B plasma levels, J Intern Med, 259, 437, 10.1111/j.1365-2796.2006.01648.x

Packard, 2006, Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease, Curr Opin Lipidol, 17, 412, 10.1097/01.mol.0000236367.42755.c1

Boden, 2001, Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects, Diabetes, 50, 1612, 10.2337/diabetes.50.7.1612

Jacob, 1999, Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects, Diabetes, 48, 1113, 10.2337/diabetes.48.5.1113

Krssak, 1999, Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study, Diabetologia, 42, 113, 10.1007/s001250051123

Virkamaki, 2001, Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle, Diabetes, 50, 2337, 10.2337/diabetes.50.10.2337

Boden, 2002, Interaction between free fatty acids and glucose metabolism, Curr Opin Clin Nutr Metab Care, 5, 545, 10.1097/00075197-200209000-00014

Holland, 2007, Lipid mediators of insulin resistance, Nutr Rev, 65, S39, 10.1301/nr.2007.jun.S39-S46

Bergman, 2006, Why visceral fat is bad: mechanisms of the metabolic syndrome, Obesity (Silver Spring), 14, 16S, 10.1038/oby.2006.277

Jensen, 2003, Splanchnic free fatty acid kinetics, Am J Physiol Endocrinol Metab, 284, E1140, 10.1152/ajpendo.00268.2002

Kraegen, 1991, Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats, Diabetes, 40, 1397, 10.2337/diab.40.11.1397

Petersen, 2006, Etiology of insulin resistance, Am J Med, 119, S10, 10.1016/j.amjmed.2006.01.009

Lonardo, 2006, Hepatic steatosis and insulin resistance: does etiology make a difference?, J Hepatol, 44, 190, 10.1016/j.jhep.2005.06.018

Perez-Martinez, 2007, Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucasian population, Lipids, 42, 143, 10.1007/s11745-007-3027-7

Perez-Martinez, 2007, The APOB -516C/T polymorphism is associated with differences in insulin sensitivity in healthy males during the consumption of diets with different fat content, Br J Nutr, 97, 622, 10.1017/S0007114507659005

Bandsma, 2002, Disturbed lipid metabolism in glycogen storage disease type 1, Eur J Pediatr, 161, S65, 10.1007/s00431-002-1007-8

Havel, 1969, Splanchnic metabolism in von Gierke's disease (glycogenosis type I), Trans Assoc Am Physicians, 82, 305

Bjorkegren, 2002, Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury, J Biol Chem, 277, 5476, 10.1074/jbc.M108514200

Monetti, 2007, Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver, Cell Metab, 6, 69, 10.1016/j.cmet.2007.05.005

Gutierrez-Juarez, 2006, Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance, J Clin Invest, 116, 1686, 10.1172/JCI26991

Gibbons, 2004, Synthesis and function of hepatic very-low-density lipoprotein, Biochem Soc Trans, 32, 59, 10.1042/bst0320059

Millar, 2006, Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production, J Lipid Res, 47, 2297, 10.1194/jlr.M600213-JLR200

Puri, 2007, A lipidomic analysis of nonalcoholic fatty liver disease, Hepatology, 46, 1081, 10.1002/hep.21763