From T‐cell activation signals to signaling control of anti‐cancer immunity

Immunological Reviews - Tập 220 Số 1 - Trang 151-168 - 2007
Shane J. F. Cronin1, Josef Penninger1
1IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria

Tóm tắt

Summary: The activation of resting T cells is crucial to most immune processes. Recognition of foreign antigen by T‐cell receptors has to be correctly translated into signal transduction events necessary for the induction of an effective immune response. In this review, we discuss the essential signals, molecules, and processes necessary to achieve full T‐cell activation. In addition to describing these key biological events, we also discuss how T‐cell receptor signaling may be harnessed to yield new therapeutic targets for a next generation of anti‐cancer drugs.

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Tài liệu tham khảo

Medzhitov R, 1997, Innate immunity, the virtues of a nonclonal system of recognition, 91, 295

10.1016/S0092-8674(01)00456-1

Lee HK, 2007, Innate control of adaptive immunity, dendritic cells and beyond, 19, 48

Steinman RM, 2006, Dendritic cells, translating innate to adaptive immunity, 311, 17

10.1038/ni957

10.1016/S0167-5699(97)80008-4

Avni O, 2000, T cell differentiation, a mechanistic view, 12, 654

Harrington LE, 2006, Expanding the effector CD4 T‐cell repertoire, the Th17 lineage, 18, 349

Weaver CT, 2006, Th17, an effector CD4 T cell lineage with regulatory T cell ties, 24, 677

10.1126/science.7518614

Honjo T, 2002, Molecular mechanism of class switch recombination, linkage with somatic hypermutation, 20, 165

10.1038/90950

10.1146/annurev.ge.25.120191.002415

Samelson LE, 2002, Signal transduction mediated by the T cell antigen receptor, the role of adapter proteins, 20, 371

10.1146/annurev.immunol.18.1.165

10.1016/0952-7915(94)90115-5

Clevers H, 1988, The T cell receptor/CD3 complex, a dynamic protein ensemble, 6, 629

10.1038/350062a0

10.1016/0092-8674(92)90428-F

10.1111/j.1600-065X.1998.tb01238.x

Penninger JM, 2001, CD45, new jobs for an old acquaintance, 2, 389

Mustelin T, 1990, Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45), Oncogene, 5, 809

D'Oro U, 1999, Cutting edge, the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes, 162, 1879

10.1073/pnas.97.18.10138

Weiss A, 1984, Role of T3 surface molecules in human T‐cell activation, T3-dependent activation results in an increase in cytoplasmic free calcium, 81, 4169

10.1016/0092-8674(85)90206-5

Partiseti M, 1994, Defective transmembrane calcium influx demonstrated in a primary immunodeficiency by video‐imaging, C R Acad Sci III, 317, 167

10.1038/86318

10.1038/31960

Crabtree GR, 2002, NFAT signaling, choreographing the social lives of cells, 109, S67

10.1146/annurev.immunol.20.100301.064807

10.1038/25764

Grakoui A, 1999, The immunological synapse, a molecular machine controlling T cell activation, 285, 221

10.1126/science.1086507

10.1038/ni741

10.1038/ni1095

10.1038/nature03391

Van Kooyk Y, 2000, Avidity regulation of integrins, the driving force in leukocyte adhesion, 12, 542

10.1016/0167-5699(90)90112-M

10.1038/nature02916

10.1038/ni1304

10.1016/S1074-7613(04)00106-2

10.1006/smim.1998.0124

10.1016/S0092-8674(00)00085-4

10.1074/jbc.M208039200

10.1002/1521-4141(200202)32:2<435::AID-IMMU435>3.0.CO;2-H

10.1126/science.1067710

10.1038/374474a0

10.1038/374467a0

10.1038/374470a0

10.1084/jem.188.11.2099

10.1016/S0960-9822(98)70224-6

10.1002/(SICI)1521-4141(199905)29:05<1709::AID-IMMU1709>3.0.CO;2-O

10.1073/pnas.96.6.3035

10.1093/emboj/cdf499

10.4049/jimmunol.171.3.1360

10.1002/eji.200323858

10.1038/ni1039

10.1016/S1074-7613(02)00291-1

10.1128/MCB.15.8.4337

10.1084/jem.20011663

10.1016/j.immuni.2006.10.010

10.1038/nri1352

Baier G, 2003, The PKC gene module, molecular biosystematics to resolve its T cell functions, 192, 64

10.1016/S0092-8674(00)80957-5

10.1038/8767

10.1016/S0092-8674(01)00189-1

Morgan JA, 1999, Breakpoints of the t(11;18)(q21;q21) in mucosa‐associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18, Cancer Res, 59, 6205

10.1038/sj.onc.1203018

Uren AG, 2000, Identification of paracaspases and metacaspases, two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma, 6, 961

10.1074/jbc.M009984200

10.1016/S1097-2765(04)00236-9

10.1016/S0014-5793(01)02414-0

10.1074/jbc.M010512200

10.1074/jbc.M103824200

10.1002/(SICI)1521-1878(199911)21:11<912::AID-BIES3>3.0.CO;2-Z

10.1016/j.immuni.2005.10.007

10.1016/j.immuni.2005.09.014

10.1016/S0960-9822(03)00491-3

10.1016/S1074-7613(03)00148-1

10.1084/jem.20032246

10.1038/nature02273

10.1074/jbc.M303389200

10.1016/S0092-8674(00)81466-X

10.1038/sj.emboj.7601622

Shimizu Y, 1990, Roles of adhesion molecules in T‐cell recognition, fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation, 114, 109

10.4049/jimmunol.144.12.4579

10.1126/science.1763329

10.1126/science.1063397

10.1126/science.1063486

10.1126/science.1137895

10.1146/annurev.iy.11.040193.001203

10.1146/annurev.immunol.14.1.591

10.1172/JCI0214941

Rudd CE, 1996, Upstream‐downstream, CD28 cosignaling pathways and T cell function, 4, 527

10.1111/j.1600-065X.1998.tb01242.x

Slavik JM, 1999, CD28/CTLA‐4 and CD80/CD86 families, signaling and function, 19, 1

10.1016/S1074-7613(01)00244-8

10.4049/jimmunol.165.7.3820

10.4049/jimmunol.168.6.2729

10.1016/1074-7613(95)90161-2

10.4049/jimmunol.167.6.3285

Zhang J, 2002, Cutting edge, regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination, 169, 2236

10.1038/328267a0

10.1084/jem.174.3.561

Perkins D, 1996, Regulation of CTLA‐4 expression during T cell activation, J Immunol, 156, 4154, 10.4049/jimmunol.156.11.4154

Chambers CA, 2001, CTLA‐4‐mediated inhibition in regulation of T cell responses, mechanisms and manipulation in tumor immunotherapy, 19, 565

10.1084/jem.183.6.2541

10.1126/science.270.5238.985

10.1016/1074-7613(95)90125-6

Li D, 2004, Cutting edge, Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation, 173, 7135

10.1038/70932

10.1038/85330

10.1093/intimm/8.5.765

10.1073/pnas.0505497102

10.1126/science.291.5502.319

10.1084/jem.20050019

10.1084/jem.20050072

10.4049/jimmunol.175.3.1586

10.1016/j.it.2005.06.003

Richter G, 2004, ICOS, a new costimulatory ligand/receptor pair and its role in T-cell activion, 27, 91

10.1038/nri1371

10.1002/1097-0142(196611)19:11<1743::AID-CNCR2820191143>3.0.CO;2-U

10.1016/S0065-230X(01)83005-0

10.1016/S0952-7915(00)00198-9

10.1016/j.cytogfr.2007.01.015

Smyth MJ, 2006, Cancer immunosurveillance and immunoediting, the roles of immunity in suppressing tumor development and shaping tumor immunogenicity, 90, 1

Jarnicki AG, 2006, Suppression of antitumor immunity by IL‐10 and TGF‐beta‐producing T cells infiltrating the growing tumor, influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells, 177, 896

10.1084/jem.180.6.2371

Salazar‐Onfray F, 1997, Down‐regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL‐10, J Immunol, 159, 3195, 10.4049/jimmunol.159.7.3195

10.1002/pros.20661

Thompson RH, 2004, Costimulatory B7 H1 in renal cell carcinoma patients, indicator of tumor aggressiveness and potential therapeutic target, 101, 17174

10.1007/s00262-004-0593-x

10.1146/annurev.immunol.21.120601.141110

10.1038/ni1047

10.1016/S0092-8674(02)00767-5

Keane MM, 1999, cbl‐3, a new mammalian cbl family protein, 18, 3365

10.1016/S0378-1119(99)00356-X

Keane MM, 1995, Cloning and characterization of cbl‐b, a SH3 binding protein with homology to the c-cbl proto-oncogene, 10, 2367

10.1073/pnas.86.4.1168

10.1128/MCB.23.21.7708-7718.2003

10.1016/S0378-1119(03)00471-2

10.1038/sj.onc.1207952

10.1074/jbc.274.43.30887

Thien CB, 2005, c‐Cbl and Cbl‐b ubiquitin ligases, substrate diversity and the negative regulation of signalling responses, 391, 153

10.1080/08977190500153763

10.1038/nrm1762

10.4049/jimmunol.162.12.7133

10.1128/MCB.18.8.4872

10.1073/pnas.95.26.15547

10.1038/35003228

10.1038/35003235

10.1016/S1074-7613(00)00046-7

10.1074/jbc.M008901200

10.1038/ni0901-870

10.1038/sj.onc.1202411

10.1016/j.immuni.2004.07.013

10.1038/nm1114

Wohlfert EA, 2006, Cutting edge, deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo, 176, 1316

10.4049/jimmunol.173.2.1059

10.1038/ni1193

10.1126/science.7678351

10.1126/science.271.5256.1734

Yang YF, 1997, Enhanced induction of antitumor T‐cell responses by cytotoxic T lymphocyte‐associated molecule‐4 blockade, the effect is manifested only at the restricted tumor-bearing stages, 57, 4036

10.1084/jem.190.3.355

10.1073/pnas.1533209100

10.1200/JCO.2005.06.205

10.1158/1078-0432.CCR-06-2746

Ghebeh H, 2006, The B7‐H1 (PD‐L1) T lymphocyte‐inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma, correlation with important high-risk prognostic factors, 8, 190

10.1038/nature04444

10.1158/0008-5472.CAN-05-4303

10.1002/ijc.21775

10.1093/intimm/dxh194

Lin KY, 1996, Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen, Cancer Res, 56, 21

10.1084/jem.20061699

10.1172/JCI29472