Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

Journal of Autism and Developmental Disorders - Tập 47 - Trang 2671-2678 - 2017
Khaled Saad1, Asmaa M. Zahran2, Khalid I. Elsayh1, Ahmed A. Abdel-Rahman3, Abdulrahman A. Al-Atram4, Almontaser Hussein1, Yasmin G. El-Gendy5
1Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt
2Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt
3Department of Neuropsychiatry, Faculty of Medicine, Assiut University, Assiut, Egypt
4Department of Psychiatry, College of Medicine, Almajmaah University, Almajmaah, Kingdom of Saudi Arabia
5Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Tóm tắt

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.

Tài liệu tham khảo

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