Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal study

Alzheimer's & Dementia - Tập 15 - Trang 1208-1217 - 2019
Jin-Tai Yu1, Jie-Qiong Li2, John Suckling3,4,5, Lei Feng6, An Pan7, Yan-Jiang Wang8, Bo Song9, Shan-Liang Zhu10, De-Hu Li10, Hui-Fu Wang2, Chen-Chen Tan2, Qiang Dong1, Lan Tan2, Vincent Mok11, Paul S. Aisen12, Michael M. Weiner13,14,15,16,17
1Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
2Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China
3Department of Psychiatry, University of Cambridge, Cambridge, UK
4Medical Research Council and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
5Cambridgeshire and Peterborough NHS Trust, Cambridge, UK
6Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
7Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
8Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China
9College of Information Science and Technology, Qingdao University of Science and Technology, Qingdao, China
10Research Center for Mathematical Modeling, School of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao, China
11Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Therese Pei Fong Chow Research Center for Prevention of Dementia, Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
12Alzheimer’s Therapeutic Research Institute, University of Southern California, San Diego, CA, USA
13Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
14Department of Radiology, University of California, San Francisco, CA, USA
15Department of Medicine, University of California, San Francisco, CA USA
16Department of Psychiatry, University of California, San Francisco, CA, USA
17Department of Neurology, University of California, San Francisco, CA, USA

Tóm tắt

AbstractIntroduction

We aimed to estimate the frequency of each AT(N) (β‐amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in clinical outcomes of individuals in each group.

Methods

Longitudinal change in clinical outcomes and conversion risk of AT(N) profiles are assessed using linear mixed‐effects models and multivariate Cox proportional‐hazard models, respectively.

Results

Participants with A+T+N+ showed faster clinical progression than those with A−T−N− and A+T±N−. Compared with A−T−N−, participants with A+T+N± had an increased risk of conversion from cognitively normal (CN) to incident prodromal stage of Alzheimer's disease (AD), and from MCI to AD dementia. A+T+N+ showed an increased conversion risk when compared with A+T±N−.

Discussion

The 2018 research framework may provide prognostic information of clinical change and progression. It may also be useful for targeted recruitment of participants with AD into clinical trials.


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Alzheimer's & Dementia

Tập 15

1208-1217

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