Frequency and Risk Factors of Postoperative Recurrence of Crohn’s Disease After Intestinal Resection in the Chinese Population

Elsevier BV - Tập 16 - Trang 1539-1547 - 2012
Yi Li1, Weiming Zhu1, Lugen Zuo1, Wei Zhang, Jianfeng Gong1, Lili Gu1, Lei Cao1, Ning Li1, Jieshou Li1
1Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China

Tóm tắt

Data on risk factors of postoperative recurrence in patients with Crohn’s disease (CD) have shown conflicting results. The aim of this retrospective study is to identify predictors of early symptomatic recurrence of CD after surgical intestinal resection in the Chinese population. Patients diagnosed as CD who underwent intestinal resection in Jinling Hospital between May 2004 and December 2010 were included in our study. Clinical data of these patients were reviewed. Multivariable survival analysis was performed to elucidate risk factors of early postoperative symptomatic recurrence. There were a total of 141 CD patients who had at least one previous curative resection for CD under regular follow-up in our unit. Our data indicated disease behavior (95 % CI 1.01–1.70, P = 0.044), smoking habits (95 % CI 1.32–2.84, P = 0.001), indication of perforation (95 % CI 1.09–4.02, P = 0.026), and location of anastomosis (95 % CI 1.09–3.39, P = 0.023) which are, as a result, strong independent predictors of symptomatic recurrence, while the anastomosis type as side-to-side anastomosis (SSA) was significantly associated with a decreased risk of symptomatic recurrence when compared with other anastomosis type (95 % CI 0.26–0.94, P = 0.038). Medical prophylaxes also played a role in the prevention of postoperative symptomatic recurrence. A smoking habits and perforation indication for surgery at the time of resection are associated with an increased risk of symptomatic recurrence. Anastomosis type with SSA is associated with a reduced risk of symptomatic recurrence. This population-based study supports the concept that environmental factors, disease character, and surgical technique influence the risk of postoperative symptomatic recurrence of CD.

Tài liệu tham khảo

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