Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4

Nakamura, 2018, Mechanisms of physiological and pathological cardiac hypertrophy, Nat. Rev. Cardiol., 15, 387, 10.1038/s41569-018-0007-y Grassi, 2021, Sympathetic activation in congestive heart failure: an updated overview, Heart Fail. Rev., 26, 173, 10.1007/s10741-019-09901-2 Ali, 2020, beta-Adrenergic receptor, an essential target in cardiovascular diseases, Heart Fail, Rev., 25, 343 Seo, 2020, Stretch-induced biased signaling in angiotensin II Type 1 and apelin receptors for the mediation of cardiac contractility and hypertrophy, Front. Physiol., 11, 1, 10.3389/fphys.2020.00181 Koh, 2016, From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites, Cell, 165, 1332, 10.1016/j.cell.2016.05.041 Nilsson, 2003, Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids, Biochem, Biophys. Res. Commun., 303, 1047, 10.1016/S0006-291X(03)00488-1 Brown, 2003, The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids, J. Biol. Chem., 278, 11312, 10.1074/jbc.M211609200 Poul, 2003, Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation, J. Biol. Chem., 278, 25481, 10.1074/jbc.M301403200 Bartoszek, 2020, Free fatty acid receptors as new potential therapeutic target in inflammatory bowel diseases, Pharmacol. Res., 152, 1, 10.1016/j.phrs.2019.104604 Offermanns, 2014, Free fatty acid (FFA) and hydroxy carboxylic acid (HCA) receptors, Annu. Rev. Pharmacol. Toxicol., 54, 407, 10.1146/annurev-pharmtox-011613-135945 Wang, 2009, Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genes, J. Dairy Sci., 92, 2696, 10.3168/jds.2009-2037 Hong, 2005, Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43, Endocrinology, 146, 5092, 10.1210/en.2005-0545 Vieira, 2015, A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout, Arthritis Rheumatol., 67, 1646, 10.1002/art.39107 Kim, 2013, Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice, Gastroenterology, 145, 396, 10.1053/j.gastro.2013.04.056 Sina, 2009, G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation, J. Immunol., 183, 7514, 10.4049/jimmunol.0900063 Smith, 2011, Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator, Mol. Pharmacol., 80, 163, 10.1124/mol.110.070789 Lee, 2008, Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2, Mol. Pharmacol., 74, 1599, 10.1124/mol.108.049536 Singh, 2017, Protein kinase C and cardiac dysfunction: a review, Heart Fail. Rev., 22, 843, 10.1007/s10741-017-9634-3 Liu, 2016, Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs), J. Mol. Cell. Cardiol., 101, 44, 10.1016/j.yjmcc.2016.08.018 Harhous, 2019, An update on the multifaceted roles of STAT3 in the heart, Front. Cardiovasc. Med., 6, 1, 10.3389/fcvm.2019.00150 Katanasaka, 2016, Regulation of cardiac transcription factor GATA4 by post-translational modification in cardiomyocyte hypertrophy and heart failure, Int. Heart J., 57, 672, 10.1536/ihj.16-404 Gao, 2018, Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: the role of PKCzeta-NF-kappaB pathway, Mol. Cell. Endocrinol., 470, 259, 10.1016/j.mce.2017.11.007 Li, 2019, Sirtuin 1 represses PKC-zeta activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy, Br. J. Pharmacol., 176, 416, 10.1111/bph.14538 Tang, 2011, Mitogen-activated protein kinases ERK 1/2- and p38-GATA4 pathways mediate the Ang II-induced activation of FGF2 gene in neonatal rat cardiomyocytes, Biochem. Pharmacol., 81, 518, 10.1016/j.bcp.2010.11.012 Zhang, 2016, STAT3 Suppression is involved in the protective effect of SIRT6 against cardiomyocyte hypertrophy, J. Cardiovasc. Pharmacol., 68, 204, 10.1097/FJC.0000000000000404 Yang, 2011, GATA4 loss-of-function mutations in familial atrial fibrillation, Clin. Chim. Acta, 412, 1825, 10.1016/j.cca.2011.06.017 Grundmann, 2016, A molecular mechanism for sequential activation of a G protein-coupled receptor, Cell Chem. Biol., 23, 392, 10.1016/j.chembiol.2016.02.014 Schmidt, 2011, Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3, J. Biol. Chem., 286, 10628, 10.1074/jbc.M110.210872 Hansen, 2018, Discovery of a potent thiazolidine free fatty acid receptor 2 agonist with favorable pharmacokinetic properties, J. Med. Chem., 61, 9534, 10.1021/acs.jmedchem.8b00855 Sun, 2019, Maf1 ameliorates cardiac hypertrophy by inhibiting RNA polymerase III through ERK1/2, Theranostics, 9, 7268, 10.7150/thno.33006 Kimura, 2013, The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43, Nat. Commun., 4, 1, 10.1038/ncomms2852 Maslowski, 2009, Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43, Nature, 461, 1282, 10.1038/nature08530 Shimizu, 2016, Physiological and pathological cardiac hypertrophy, J. Mol. Cell. Cardiol., 97, 245, 10.1016/j.yjmcc.2016.06.001 Li, 2014, Identification of the porcine G protein-coupled receptor 41 and 43 genes and their expression pattern in different tissues and development stages, PLoS One, 9, 1, 10.1371/journal.pone.0097342 Patwardhan, 2021, Post-translational modifications of G protein-coupled receptors control cellular signaling dynamics in space and time, Pharmacol. Rev., 73, 120, 10.1124/pharmrev.120.000082 Janezic, 2020, N-glycosylation of α1D-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis, Sci Rep., 10, 7209, 10.1038/s41598-020-64102-4 Gentzsch, 1997, Protein-O-glycosylation in yeast: protein-specific mannosyltransferases, Glycobiology, 7, 481, 10.1093/glycob/7.4.481 Crispino, 2001, Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors, Gene. Dev., 15, 839, 10.1101/gad.875201 Kuo, 1997, GATA4 transcription factor is required for ventral morphogenesis and heart tube formation, Gene. Dev., 11, 1048, 10.1101/gad.11.8.1048 Liang, 2001, The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo, J. Biol. Chem., 276, 30245, 10.1074/jbc.M102174200 Unudurthi, 2018, betaIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload, J. Clin. Invest., 128, 5561, 10.1172/JCI99245 Pan, 1997, Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart, Circ. Res., 81, 611, 10.1161/01.RES.81.4.611 Yue, 2010, Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy, Cardiovasc. Res., 85, 90, 10.1093/cvr/cvp285 Kunisada, 2000, Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy, Proc. Natl. Acad. Sci. U.S.A., 97, 315, 10.1073/pnas.97.1.315 Ye, 2020, Celastrol attenuates angiotensin II-induced cardiac remodeling by targeting STAT3, Circ. Res., 126, 1007, 10.1161/CIRCRESAHA.119.315861 Mir, 2012, Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart, J. Biol. Chem., 287, 2666, 10.1074/jbc.M111.246173 Zhao, 2018, GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3, Mucosal. Immunol., 11, 752, 10.1038/mi.2017.118 Sun, 2018, Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis, Nat. Commun., 9, 1, 10.1038/s41467-018-05901-2 Chun, 2019, Metabolite-sensing receptor Ffar2 regulates colonic group 3 innate lymphoid cells and gut immunity, Immunity, 51, 871, 10.1016/j.immuni.2019.09.014 Bolognini, 2016, A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias, J. Biol. Chem., 291, 18915, 10.1074/jbc.M116.736157 Nadeem, 2017, GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model, Cell. Signal., 33, 59, 10.1016/j.cellsig.2017.02.014 Nakajima, 2017, The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages, PLoS One, 12, 1, 10.1371/journal.pone.0179696 Bueno, 2000, The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice, The EMBO journal, 19, 6341, 10.1093/emboj/19.23.6341 Falomir-Lockhart, 2019, Fatty acid signaling mechanisms in neural cells: fatty acid receptors, Front. Cell. Neurosci., 13, 162, 10.3389/fncel.2019.00162 Jaworska, 2019, Effect of the HDAC inhibitor, sodium butyrate, on neurogenesis in a rat model of neonatal hypoxia–ischemia: potential mechanism of action, Mol Neurobiol., 56, 6341, 10.1007/s12035-019-1518-1 Aoyama, 2010, Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways, Nutrition, 26, 653, 10.1016/j.nut.2009.07.006 Xu, 2017, Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation, Signal. Transduct. Target. Ther., 2, 1, 10.1038/sigtrans.2016.35