Frailty, Sarcopenia and Long Term Care Utilization in Older Populations: A Systematic Review

SERDI - Tập 10 - Trang 272-280 - 2021
Q. Roquebert1,2, Jonathan Sicsic1,3, B. Santos-Eggimann4, N. Sirven1, T. Rapp1,5
1LIRAES (EA4470), Université de Paris, Paris, France
2Université de Strasbourg, Université de Lorraine, CNRS, BETA, Strasbourg, France
3LIRAES, Université de Paris, Paris, France
4Centre universitaire de médecine générale et santé publique (Unisanté), Université de Lausanne, Lausanne, Switzerland
5LIEPP, Sciences Po, Paris, France

Tóm tắt

This systematic literature review documents the link between frailty or sarcopenia, conceptualized as dimensions of physical health, and the use of long-term care services by older individuals. Long-term care services include formal and informal care provided at home as well as in institutions. A systematic review was performed according to PRISMA requirements using the following databases: PubMed-Medline, Embase, CINAHL, Web of Science, and Academic Search Premier. We included all quantitative studies published in English between January 2000 and December 2018 focusing on individuals aged 50 or more, using a relevant measurement of sarcopenia or physical frailty and a long-term care related outcome. A quality assessment was carried out using the questionnaire established by the Good Practice Task Force Report of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Five subsets of long-term care outcome were considered: 1/ nursing home placement (NHP), 2/ nursing home short stay (NHSS), 3/ formal personal care (FPC), 4/ formal home help (FHH), 5/ informal care (IC). Out of 1943 studies, 17 were finally included in the review. With some studies covering several LTC outcomes, frailty and / or sarcopenia were associated with increased LTC use in 17 out of 26 cases (NHP: 5/6, NHSS: 3/4, FPC: 5/7, FHH: 1/4, IC: 3/5) The association was not consistent in 5 cases (NHP: 1/6, NHSS: 1/4, FPC: 2/7, FHH: 0/4, IC: 1/5) and the association was either not significant or the results inconclusive in the remaining 9 cases. Overall, while results on sarcopenia are scarce, evidence support a positive association between frailty and LTC use. The evidence is stronger for the association of physical frailty with nursing home placement / short stay as well as on FPC. There is less (more heterogeneous) evidence regarding the correlation between physical frailty and FHH or IC use. Results need to be confirmed by more advanced statistical methods or design based on longitudinal data.

Tài liệu tham khảo

Costa-Font, J., Courbage, C., Swartz, K.: Financing Long-Term Care: ex-ante, ex-post or both? Health Econ. 2015;24, 45–57. https://doi.org/10.1002/hec.3152 OCDE: Health at a Glance 2019: OECD indicators. European Commission, Directorate-General for Economic and Financial Affairs, Economic Policy Committee of the European Communities: The 2018 ageing report: underlying assumptions and projection methodologies. 2017 Marcell, T.J.: Sarcopenia: causes, consequences, and preventions. J. Gerontol. A. Biol. Sci. Med. Sci. 2003;58, M911–916 Cesari, M., Landi, F., Vellas, B., Bernabei, R., Marzetti, E.: Sarcopenia and Physical Frailty: Two Sides of the Same Coin. Front. Aging Neurosci. 2014;6. https://doi.org/10.3389/fnagi.2014.00192 Malmstrom, T.K., Morley, J.E.: SARC-F: a simple questionnaire to rapidly diagnose sarcopenia. J. Am. Med. Dir. Assoc. 2013;14, 531–532. https://doi.org/10.1016/j.jamda.2013.05.018 Studenski, S.A., Peters, K.W., Alley, D.E., Cawthon, P.M., McLean, R.R., Harris, T.B., Ferrucci, L., Guralnik, J.M., Fragala, M.S., Kenny, A.M., Kiel, D.P., Kritchevsky, S.B., Shardell, M.D., Dam, T.-T.L., Vassileva, M.T.: The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J. Gerontol. A. Biol. Sci. Med. Sci. 2014;69, 547–558. https://doi.org/10.1093/gerona/glu010 Cawthon, P.M., Peters, K.W., Shardell, M.D., McLean, R.R., Dam, T.-T.L., Kenny, A.M., Fragala, M.S., Harris, T.B., Kiel, D.P., Guralnik, J.M., Ferrucci, L., Kritchevsky, S.B., Vassileva, M.T., Studenski, S.A., Alley, D.E.: Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J. Gerontol. A. Biol. Sci. Med. Sci. 2014;69, 567–575. https://doi.org/10.1093/gerona/glu023 Kojima, G.: Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis. J. Epidemiol. Community Health. 2016;70, 722–729. https://doi.org/10.1136/jech-2015-206978 Wang, S.-Y., Shamliyan, T.A., Talley, K.M.C., Ramakrishnan, R., Kane, R.L.: Not just specific diseases: systematic review of the association of geriatric syndromes with hospitalization or nursing home admission. Arch. Gerontol. Geriatr. 2013;57, 16–26. https://doi.org/10.1016/j.archger.2013.03.007 Kojima, G.: Frailty as a Predictor of Nursing Home Placement Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. J. Geriatr. Phys. Ther. 2018;2001. 41, 42–48. https://doi.org/10.1519/JPT.0000000000000097 Cawthon, P.M., Fox, K.M., Gandra, S.R., Delmonico, M.J., Chiou, C.-F., Anthony, M.S., Sewall, A., Goodpaster, B., Satterfield, S., Cummings, S.R., Harris, T.B.: Do Muscle Mass, Muscle Density, Strength, and Physical Function Similarly Influence Risk of Hospitalization in Older Adults? J. Am. Geriatr. Soc. 2009;57, 1411–1419. https://doi.org/10.1111/j.1532-5415.2009.02366.x Centre for Reviews and Dissemination: Systematic Reviews. CRD’s guidance for undertaking reviews in health care. the Centre for Reviews and Dissemination, York 2009 Berger, M.L., Martin, B.C., Husereau, D., Worley, K., Allen, J.D., Yang, W., Quon, N.C., Mullins, C.D., Kahler, K.H., Crown, W.: A Questionnaire to Assess the Relevance and Credibility of Observational Studies to Inform Health Care Decision Making: An ISPOR-AMCP-NPC Good Practice Task Force Report. Value Health. 2014;17, 143–156. https://doi.org/10.1016/j.jval.2013.12.011 Rothman, M.D., Leo-Summers, L., Gill, T.M.: Prognostic Significance of Potential Frailty Criteria. J. Am. Geriatr. Soc. 2008;56, 2211–2216. https://doi.org/10.1111/j.1532-5415.2008.02008.x Rochat, S., Cumming, R.G., Blyth, F., Creasey, H., Handelsman, D., Le Couteur, D.G., Naganathan, V., Sambrook, P.N., Seibel, M.J., Waite, L.: Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. AGE AGEING. 2010;39, 228–233. https://doi.org/10.1093/ageing/afp257 Gobbens, R.J.J., van Assen, M.A.L.M., Luijkx, K.G., Schols, J.M.G.A.: The Predictive Validity of the Tilburg Frailty Indicator: Disability, Health Care Utilization, and Quality of Life in a Population at Risk. The Gerontologist. 2012;52, 619–631. https://doi.org/10.1093/geront/gnr135 Hoeck, S., Francois, G., Geerts, J., Van der Heyden, J., Vandewoude, M., Van Hal, G.: Health-care and home-care utilization among frail elderly persons in Belgium. Eur. J. Public Health. 2012;22, 671–677. https://doi.org/10.1093/eurpub/ckr133 Bentur N., Sternberg S.A., Shuldiner J.: Frailty transitions in community-dwelling older people. Isr. Med. Assoc. J. 2016;18, 449–453 Hirani, V., Blyth, F., Naganathan, V., Le Couteur, D.G., Seibel, M.J., Waite, L.M., Handelsman, D.J., Cumming, R.G.: Sarcopenia Is Associated With Incident Disability, Institutionalization, and Mortality in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. J. Am. Med. Dir. Assoc. 2015;16, 607–613. https://doi.org/10.1016/j.jamda.2015.02.006 Bock, J.-O., König, H.-H., Brenner, H., Haefeli, W.E., Quinzler, R., Matschinger, H., Saum, K.-U., Schöttker, B., Heider, D.: Associations of frailty with health care costs — results of the ESTHER cohort study. BMC Health Serv. Res. 2016;16, 128. https://doi.org/10.1186/s12913-016-1360-3 Gonzalez-Colaço Harmand, M., Meillon, C., Bergua, V., Tabue Teguo, M., Dartigues, J.-F., Avila-Funes, J.A., Amieva, H.: Comparing the predictive value of three definitions of frailty: Results from the Three-City study. Arch. Gerontol. Geriatr. 2017;72, 153–163. https://doi.org/10.1016/j.archger.2017.06.005 Ferrante, L.E., Pisani, M.A., Murphy, T.E., Gahbauer, E.A., Leo-Summers, L.S., Gill, T.M.: The Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study. Chest. 2018;153, 1378–1386. https://doi.org/10.1016/j.chest.2018.03.007 Hajek, A., Bock, J.-O., Saum, K.-U., Matschinger, H., Brenner, H., Holleczek, B., Haefeli, W.E., Heider, D., Koenig, H.-H.: Frailty and healthcare costs-longitudinal results of a prospective cohort study. Age Ageing. 2018;47, 233–241. https://doi.org/10.1093/ageing/afx157 Lambotte, D., De Donder, L., Van Regenmortel, S., Fret, B., Dury, S., Smetcoren, A.-S., Dierckx, E., De Witte, N., Verte, D., Kardol, M.J.M., Consortium, D.-S.: Frailty differences in older adults’ use of informal and formal care. Arch. Gerontol. Geriatr. 2018;79, 69–77. https://doi.org/10.1016/j.archger.2018.05.018 Verver, D., Merten, H., Robben, P., Wagner, C.: Care and support for older adults in The Netherlands living independently. Health Soc. Care Community. 2018;26, e404–e414. https://doi.org/10.1111/hsc.12539 Hogan, D.B., Freiheit, E.A., Strain, L.A., Patten, S.B., Schmaltz, H.N., Rolfson, D., Maxwell, C.J.: Comparing frailty measures in their ability to predict adverse outcome among older residents of assisted living. BMC Geriatr. 2012;12. https://doi.org/10.1186/1471-2318-12-56 Campitelli, M.A., Bronskill, S.E., Hogan, D.B., Diong, C., Amuah, J.E., Gill, S., Seitz, D., Thavorn, K., Wodchis, W.P., Maxwell, C.J.: The prevalence and health consequences of frailty in a population-based older home care cohort: a comparison of different measures. BMC Geriatr. 2016;16. https://doi.org/10.1186/s12877-016-0309-z Schoufour, J.D., Evenhuis, H.M., Echteld, M.A.: The impact of frailty on care intensity in older people with intellectual disabilities. Res. Dev. Disabil. 2014;35, 3455–3461. https://doi.org/10.1016/j.ridd.2014.08.006 Butler, A., Gallagher, D., Gillespie, P., Crosby, L., Ryan, D., Lacey, L., Coen, R., O’Shea, E., Lawlor, B.: Frailty: a costly phenomenon in caring for elders with cognitive impairment. Int. J. Geriatr. Psychiatry. 2016;31, 161–168. https://doi.org/10.1002/gps.4306 Kelaiditi, E., Andrieu, S., Cantet, C., Vellas, B., Cesari, M.: Frailty Index and Incident Mortality, Hospitalization, and Institutionalization in Alzheimer’s Disease: Data From the ICTUS Study. J. Gerontol. Ser. A. 2016;71, 543–548. https://doi.org/10.1093/gerona/glv137 Sicsic, J., Ravesteijn, B., Rapp, T.: Are frail elderly people in Europe high-need subjects? First evidence from the SPRINTT data. Health Policy. 2020;124, 865–872. https://doi.org/10.1016/j.healthpol.2020.05.009 Berger, M.L., Martin, B.C., Husereau, D., Worley, K., Allen, J.D., Yang, W., Quon, N.C., Mullins, C.D., Kahler, K.H., Crown, W.: A Questionnaire to Assess the Relevance and Credibility of Observational Studies to Inform Health Care Decision Making: An ISPOR-AMCP-NPC Good Practice Task Force Report. Value Health. 2014;17, 143–156. https://doi.org/10.1016/j.jval.2013.12.011