Fragrance chemicals in domestic and occupational products

Contact Dermatitis - Tập 45 Số 4 - Trang 221-225 - 2001
S. C. Rastogi1, S. Heydorn2, Jeanne Duus Johansen2, D A Basketter3
1Department of Environmental Chemistry, National Environmental Research Institute, Roskilde, Denmark
2Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark;
3SEAC Toxicology, Unilever Research, Sharnbrook, UK

Tóm tắt

Epidemiological studies have described an increasing prevalence of fragrance allergy and indicated an association with hand eczema. 59 domestic and occupational products intended for hand exposure were subjected to gas chromatography‐mass spectrometric (GC‐MS) analyses to test the hypothesis that fragrance chemicals known to have the potential to cause contact allergy but not included in fragrance mix (FM) may be common ingredients in these products. A quantitative analysis of 19 selected fragrances was performed by GC‐MS. Further analysis of GC‐MS data revealed the presence of 43 other fragrance chemicals/groups of fragrance chemicals in the products investigated. Among the 19 target substances the most commonly detected were limonene in 78%, linalool in 61% and citronellol in 47% of the products investigated. The FM ingredients were present in these products with the following frequencies: oak moss (evernic acid methylester) 2%, cinnamic alcohol 2%, cinnamic aldehyde (cinnamal) 3%, isoeugenol 5%, α‐amylcinnamic aldehyde (amyl cinnamal) 8%, hydroxycitronellal 12%, eugenol 27%, and geraniol 41%. Thus, the chemical analyses of domestic and occupational products indicates that investigation of potential contact allergy related to these products types should consider fragrance allergens additional to those in the FM, since these may occur with high frequency.

Từ khóa


Tài liệu tham khảo

Schnuch A, 1993, Epikutantestung mit der Standardreihe Erste Ergebnisse des Projektes “Informationsverbund Dermatologischer Kliniken” (IVDK), Dermatosen, 41, 60

10.1111/j.1600-0536.1995.tb00834.x

10.1111/j.1600-0536.1995.tb02048.x

10.1111/j.1600-0536.1998.tb05944.x

10.1111/j.1600-0536.1998.tb05633.x

Johansen J D, 1996, Contact allergy to popular perfumes: assessed by patch test, use test and chemical analyses, Br J Dermatol, 135, 419, 10.1046/j.1365-2133.1996.d01-1014.x

10.1111/j.1600-0536.1999.tb06231.x

EU Scientific Committee on Cosmetics and Non‐Food, 1999, Fragrance allergy in consumers – a review of the problem

10.1002/jhrc.1240181008

10.1111/j.1600-0536.1989.tb04746.x

Johansen J D, 1997, Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients’ selfreported problems?, Acta Dermato-venereologica, 77, 149, 10.2340/0001555577149153

Buckley D A, 2000, Contact allergy to individual fragrance mix constituents in relation to primary site of dermatitis, Contact Dermatitis, 43, 304

10.1093/annhyg/35.4.419

Opdyke D L J, 1975, Monographs on fragrance raw materials, Food and Cosmetics Toxicology, 13, 825

10.1111/j.1600-0536.1996.tb02139.x

Thông tin
Thông tin xuất bản

Contact Dermatitis

Tập 45 Số 4

221-225

Thông tin tác giả