Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta

Reproductive Biology and Endocrinology - Tập 6 - Trang 1-6 - 2008
Jorge E Caminos1,2,3, Susana B Bravo1, C Ruth González1, Maria F Garcés1,2, Libia A Cepeda2, Adriana C González2, Fernando Cordido3, Miguel López1,4, Carlos Diéguez1,4
1Department of Physiology, School of Medicine, University of Santiago de Compostela, Spain
2Department of Physiology and Genetic Institute, Faculty of Medicine, National University of Colombia, Bogotá, Colombia
3Endocrine Department, Hospital Juan Canalejo, Spain
4CIBER of Obesity and Nutrition, Instituto Salud Carlos III, Santiago de Compostela, Spain

Tóm tắt

Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy.

Tài liệu tham khảo

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