Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

Molecular Cell - Tập 67 - Trang 512-527.e4 - 2017
Sang-Oh Yoon1, Sejeong Shin1, Florian A. Karreth2, Gwen R. Buel1, Mark P. Jedrychowski3, David R. Plas4, Shoukat Dedhar5, Steven P. Gygi3, Philippe P. Roux6, Noah Dephoure7, John Blenis1
1Department of Pharmacology, Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
2Department of Medicine, Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
3Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
4Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45267, USA
5Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada
6Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, QC H3T 1J4, Canada
7Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA

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