Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

Developmental Cell - Tập 11 - Trang 859-871 - 2006
David A. Guertin1,2, Deanna M. Stevens1, Carson C. Thoreen1, Aurora A. Burds3, Nada Y. Kalaany1, Jason Moffat1,2, Michael Brown3, Kevin J. Fitzgerald4, David M. Sabatini1,3,2
1Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02141
2The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02141
3Center for Cancer Research and Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139
4Bristol-Myers Squibb Pharmaceutical Research Institute, Department of Applied Genomics, P.O. Box 5400, Princeton, New Jersey 08653

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Developmental Cell

Tập 11

859-871

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