Florbetapir positron emission tomography and cerebrospinal fluid biomarkers

Alzheimer's & Dementia - Tập 11 - Trang 986-993 - 2015
Ann Hake1,2, Paula T. Trzepacz1,3, Shufang Wang1, Peng Yu1, Michael Case1, Helen Hochstetler1, Michael M. Witte1, Elisabeth K. Degenhardt1,3,4, Robert A. Dean1
1Eli Lilly and Company, Indianapolis, IN, USA
2Department of Neurology; Indiana University School of Medicine; Indianapolis, IN USA
3Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
4Indiana University Health Physicians Group, Indiana University Health, Indianapolis, IN, USA

Tóm tắt

AbstractBackground

We evaluated the relationship between florbetapir‐F18 positron emission tomography (FBP PET) and cerebrospinal fluid (CSF) biomarkers.

Methods

Alzheimer's Disease Neuroimaging Initiative‐Grand Opportunity and Alzheimer's Disease Neuroimaging Initiative 2 (GO/2) healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) dementia subjects with clinical measures and CSF collected ±90 days of FBP PET data were analyzed using correlation and logistic regression.

Results

In HC and MCI subjects, FBP PET anterior and posterior cingulate and composite standard uptake value ratios correlated with CSF amyloid beta (Aβ1–42) and tau/Aβ1–42 ratios. Using logistic regression, Aβ1–42, total tau (t‐tau), phosphorylated tau181P (p‐tau), and FBP PET composite each differentiated HC versus AD. Aβ1–42 and t‐tau distinguished MCI versus AD, without additional contribution by FBP PET. Total tau and p‐tau added discriminative power to FBP PET when classifying HC versus AD.

Conclusion

Based on cross‐sectional diagnostic groups, both amyloid and tau measures distinguish healthy from demented subjects. Longitudinal analyses are needed.


Tài liệu tham khảo

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Alzheimer's & Dementia

Tập 11

986-993

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