Flavonoids can replace α‐tocopherol as an antioxidant

FEBS Letters - Tập 473 Số 2 - Trang 145-148 - 2000
F.A.A. van Acker1,2, Olga Schouten3, Guido R.M.M. Haenen2, W. J. F. van der Vijgh1, Aalt Bast2
1Department of Medical Oncology, BR-232, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
2Department of Pharmacology and Toxicology, University Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
3LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Tóm tắt

Endogenous antioxidants such as the lipid‐soluble vitamin E protect the cell membranes from oxidative damage. Glutathione seems to be able to regenerate α‐tocopherol via a so‐called free radical reductase. The transient protection by reduced glutathione (GSH) against lipid peroxidation in control liver microsomes is not observed in microsomes deficient in α‐tocopherol. Introduction of antioxidant flavonoids, such as 7‐monohydroxyethylrutoside, fisetin or naringenin, into the deficient microsomes restored the GSH‐dependent protection, suggesting that flavonoids can take over the role of α‐tocopherol as a chain‐breaking antioxidant in liver microsomal membranes.

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Tài liệu tham khảo

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FEBS Letters

Tập 473 Số 2

145-148

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