Flavonoid ingredients of Ginkgo biloba leaf extract regulate lipid metabolism through Sp1-mediated carnitine palmitoyltranferase 1A up-regulation

Journal of Biomedical Science - Tập 21 Số 1 - 2014
Ting Wei1,2, Feifei Xiong3,4, Shidong Wang5,6, Li Wang7, Yong-yu Zhang8, Qinghua Zhang9,10,11,12
1Research Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. [email protected].
2Shanghai-MOST Key Laboratory of Health and Disease Genomics, National Engineering Center for Biochip at Shanghai, Shanghai, China. [email protected].
3School of Life Science and Technology, Tongji University, Shanghai, China. [email protected].
4Shanghai-MOST Key Laboratory of Health and Disease Genomics, National Engineering Center for Biochip at Shanghai, Shanghai, China. [email protected].
5Research Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. [email protected].
6Shanghai-MOST Key Laboratory of Health and Disease Genomics, National Engineering Center for Biochip at Shanghai, Shanghai, China. [email protected].
7Shanghai-MOST Key Laboratory of Health and Disease Genomics, National Engineering Center for Biochip at Shanghai, Shanghai, China. [email protected].
8Research Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. [email protected].
9Research Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. [email protected].
10School of Life Science and Technology, Tongji University, Shanghai, China. [email protected].
11Shanghai-MOST Key Laboratory of Health and Disease Genomics, National Engineering Center for Biochip at Shanghai, Shanghai, China. [email protected].
12State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [email protected].

Tóm tắt

Từ khóa


Tài liệu tham khảo

Neuschwander-Tetri BA: Lifestyle modification as the primary treatment of NASH. Clin Liver Dis. 2009, 13: 649-665. 10.1016/j.cld.2009.07.006.

Mishra P, Younossi ZM: Current treatment strategies for non-alcoholic fatty liver disease (NAFLD). Curr Drug Discov Technol. 2007, 4: 133-140. 10.2174/157016307781483469.

Sharpless KE, Thomas JB, Christopher SJ, Greenberg RR, Sander LC, Schantz MM, Welch MJ, Wise SA: Standard reference materials for foods and dietary supplements. Anal Bioanal Chem. 2007, 389: 171-178. 10.1007/s00216-007-1315-y.

Gu X, Xie Z, Wang Q, Liu G, Qu Y, Zhang L, Pan J, Zhao G, Zhang Q: Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet. FEBS J. 2009, 276: 1450-1458. 10.1111/j.1742-4658.2009.06886.x.

Wang SD, Xie ZQ, Chen J, Wang K, Wei T, Zhao AH, Zhang QH: Inhibitory effect of Ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism. J Dig Dis. 2012, 13: 525-535. 10.1111/j.1751-2980.2012.00627.x.

Schreurs M, Kuipers F, Van der Leij FR: Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. Obes Rev. 2010, 11: 380-388. 10.1111/j.1467-789X.2009.00642.x.

McGarry JD, Brown NF: The mitochondrial carnitine palmitoyltransferase system: from concept to molecular analysis. Eur J Biochem. 1997, 244: 1-14. 10.1111/j.1432-1033.1997.00001.x.

Price N, Van der Leij F, Jackson V, Corstorphine C, Thomson R, Sorensen A, Zammit V: A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics. 2002, 80: 433-442. 10.1006/geno.2002.6845.

Shin ES, Cho SY, Lee EH, Lee SJ, Chang IS, Lee TR: Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Eur J Nutr. 2006, 45: 159-164. 10.1007/s00394-005-0576-5.

Rakhshandehroo M, Hooiveld G, Muller M, Kersten S: Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009, 4: e6796-10.1371/journal.pone.0006796.

Stefanovic-Racic M, Perdomo G, Mantell BS, Sipula IJ, Brown NF, O’Doherty RM: A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels. Am J Physiol Endocrinol Metab. 2008, 294: E969-E977. 10.1152/ajpendo.00497.2007.

Gao X, Li K, Hui X, Kong X, Sweeney G, Wang Y, Xu A, Teng M, Liu P, Wu D: Carnitine palmitoyltransferase-1A prevents free fatty acid induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. Biochem J. 2011, 435: 723-732. 10.1042/BJ20101680.

Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW: Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes. 2009, 58: 550-558. 10.2337/db08-1078.

Cheung O, Sanyal AJ: Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol. 2010, 26: 202-208. 10.1097/MOG.0b013e328337b0c4.

Xie Z, Li H, Wang K, Lin J, Wang Q, Zhao G, Jia W, Zhang Q: Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Metabolism. 2010, 59: 554-560. 10.1016/j.metabol.2009.08.022.

Xie ZQ, Liang G, Zhang L, Wang Q, Qu Y, Gao Y, Lin LB, Ye S, Zhang J, Wang H, Zhao GP, Zhang QH: Molecular mechanisms underlying the cholesterol-lowering effect of Ginkgo biloba extract in hepatocytes: a comparative study with lovastatin. Acta Pharmacol Sin. 2009, 30: 1262-1275. 10.1038/aps.2009.126.

Jung CH, Cho I, Ahn J, Jeon TI, Ha TY: Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes. Phytother Res. 2012, 27: 139-143. 10.1002/ptr.4687.

Chang CJ, Tzeng TF, Liou SS, Chang YS, Liu IM: Kaempferol regulates the lipid-profile in high-fat diet-fed rats through an increase in hepatic PPARalpha levels. Planta Med. 2011, 77: 1876-1882. 10.1055/s-0031-1279992.

Kobori M, Masumoto S, Akimoto Y, Oike H: Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol Nutr Food Res. 2011, 55: 530-540. 10.1002/mnfr.201000392.

Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada M, Yada R, Harada N, Takayanagi R, Nakamuta M: Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 2007, 20: 351-358.

Reddy JK, Hashimoto T: Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Annu Rev Nutr. 2001, 21: 193-230. 10.1146/annurev.nutr.21.1.193.

Shinozuka K, Umegaki K, Kubota Y, Tanaka N, Mizuno H, Yamauchi J, Nakamura K, Kunitomo M: Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life Sci. 2002, 70: 2783-2792. 10.1016/S0024-3205(02)01530-8.

Li L, Davie JR: The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat. 2010, 192: 275-283. 10.1016/j.aanat.2010.07.010.

Singh DP, Bhargavan B, Chhunchha B, Kubo E, Kumar A, Fatma N: Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter. PLoS One. 2012, 7: e37012-10.1371/journal.pone.0037012.

Steffen ML, Harrison WR, Elder FF, Cook GA, Park EA: Expression of the rat liver carnitine palmitoyltransferase I (CPT-Ialpha) gene is regulated by Sp1 and nuclear factor Y: chromosomal localization and promoter characterization. Biochem J. 1999, 340 (Pt 2): 425-432. 10.1042/0264-6021:3400425.

Torigoe T, Izumi H, Yoshida Y, Ishiguchi H, Okamoto T, Itoh H, Kohno K: Low pH enhances Sp1 DNA binding activity and interaction with TBP. Nucleic Acids Res. 2003, 31: 4523-4530. 10.1093/nar/gkg487.

Salvatori L, Pallante P, Ravenna L, Chinzari P, Frati L, Russo MA, Petrangeli E: Oestrogens and selective oestrogen receptor (ER) modulators regulate EGF receptor gene expression through human ER alpha and beta subtypes via an Sp1 site. Oncogene. 2003, 22: 4875-4881. 10.1038/sj.onc.1206784.

Ai W, Liu Y, Wang TC: Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site. Am J Physiol Gastrointest Liver Physiol. 2006, 290: G1096-G1104. 10.1152/ajpgi.00199.2005.

Xia T, Zeng G, Gao L, Yu RK: Sp1 and AP2 enhance promoter activity of the mouse GM3-synthase gene. Gene. 2005, 351: 109-118. 10.1016/j.gene.2005.03.010.

Bouwman P, Philipsen S: Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol. 2002, 195: 27-38. 10.1016/S0303-7207(02)00221-6.

Brivanlou AH, Darnell JE: Signal transduction and the control of gene expression. Science. 2002, 295: 813-818. 10.1126/science.1066355.

Chu S, Ferro TJ: Sp1: regulation of gene expression by phosphorylation. Gene. 2005, 348: 1-11. 10.1016/j.gene.2005.01.013.

D’Addario M, Arora PD, McCulloch CA: Role of p38 in stress activation of Sp1. Gene. 2006, 379: 51-61. 10.1016/j.gene.2006.04.012.

Pan W, Chang MJ, Booyse FM, Grenett HE, Bradley KM, Wolkowicz PE, Shang Q, Tabengwa EM: Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells. J Thromb Haemost. 2008, 6: 976-985. 10.1111/j.1538-7836.2008.02977.x.

Pasten C, Olave NC, Zhou L, Tabengwa EM, Wolkowicz PE, Grenett HE: Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007, 121: 59-65. 10.1016/j.thromres.2007.02.001.

Bao M, Lou Y: Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK. Eur J Pharmacol. 2006, 547: 22-30. 10.1016/j.ejphar.2006.07.021.

Chang YC, Lee TS, Chiang AN: Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages. J Lipid Res. 2012, 53: 1840-1850. 10.1194/jlr.M024471.

Kim JY, Kim EH, Park SS, Lim JH, Kwon TK, Choi KS: Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. J Cell Biochem. 2008, 105: 1386-1398. 10.1002/jcb.21958.

Hua P, Tsai WJ, Kuo SM: Estrogen response element-independent regulation of gene expression by genistein in intestinal cells. Biochim Biophys Acta. 2003, 1627: 63-70. 10.1016/S0167-4781(03)00075-7.

Hirata Y, Masuda Y, Kakutani H, Higuchi T, Takada K, Ito A, Nakagawa Y, Ishii H: Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation. Biochem Pharmacol. 2008, 75: 1504-1514. 10.1016/j.bcp.2007.12.019.

Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E: Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007, 2007: 45673-10.1155/2007/45673.

Granado-Serrano AB, Martin MA, Bravo L, Goya L, Ramos S: Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells. Nutr Cancer. 2010, 62: 390-401. 10.1080/01635580903441196.

Sticozzi C, Belmonte G, Meini A, Carbotti P, Grasso G, Palmi M: IL-1beta induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFkappaB/Ca(2)(+)-calmodulin/ERK mitogen-activated protein kinase signaling pathway. Neuroscience. 2013, 252: 367-383. 10.1016/j.neuroscience.2013.07.061.