Flammulina velutipes polysaccharide-iron(III) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters

de Escalada Pla, 2020, Innovative strategies and nutritional perspectives for fortifying pumpkin tissue and other vegetable matrices with iron, Food Sci. Hum. Well, 9, 103, 10.1016/j.fshw.2020.02.005 Barragán-Ibañez, 2016, Iron deficiency anaemia, Rev. Med. Hosp. Gen. (Mexico City), 79, 88 Elstrott, 2020, The role of iron repletion in adult iron deficiency anemia and other diseases, Eur. J. Haematol, 104, 153, 10.1111/ejh.13345 Lopez, 2016, Iron deficiency anaemia, Lancet, 387, 907, 10.1016/S0140-6736(15)60865-0 Jankowska, 2013, Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives, Eur. Heart J., 34, 816, 10.1093/eurheartj/ehs224 Cui, 2018, A novel low molecular weight Enteromorpha polysaccharide-iron (III) complex and its effect on rats with iron deficiency anemia (IDA), Int. J. Biol. Macromol., 108, 412, 10.1016/j.ijbiomac.2017.12.033 Tolkien, 2015, Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis, PLoS One, 10, 10.1371/journal.pone.0117383 Gao, 2019, Protective effects of Ulva pertusa polysaccharide and polysaccharide-iron (III) complex on cyclophosphamide induced immunosuppression in mice, Int. J. Biol. Macromol., 133, 911, 10.1016/j.ijbiomac.2019.04.101 He, 2021, Beneficial effects of AOS-iron supplementation on intestinal structure and microbiota in IDA rats, Food Sci. Hum. Well., 10, 23, 10.1016/j.fshw.2020.05.009 Gao, 2018, Synthesis and characterization of a new soluble soybean polysaccharide-iron(III) complex using ion exchange column, Int. J. Biol. Macromol., 108, 1242, 10.1016/j.ijbiomac.2017.11.038 Liu, 2019, Preparation and characterization of a novel polysaccharide-iron(III) complex in Auricularia auricula potentially used as an iron supplement, BioMed Res. Int., 2019 Jing, 2020, Structural characteristics and antioxidant activity of polysaccharide-iron complex from Glehniae radix, International Journal of Food Properties, 23, 894, 10.1080/10942912.2020.1770787 Zhang, 2017, Characterization of a novel polysaccharide-iron(III) complex and its anti-anemia and nonspecific immune regulating activities, Mini-Rev. Med. Chem., 17, 1677, 10.2174/1389557517666170424130327 Zhang, 2018, Structural characteristics and bioactive properties of a novel polysaccharide from Flammulina velutipes, Carbohydr. Polym., 197, 147, 10.1016/j.carbpol.2018.05.069 Liang, 2021, Structural identification and coagulation effect of Flammulina velutipes polysaccharides, Appl. Sci., 11, 1736, 10.3390/app11041736 Ma, 2015, Enzymatic and acidic degradation effect on intracellular polysaccharide of Flammulina velutipes SF-08, Int. J. Biol. Macromol., 73, 236, 10.1016/j.ijbiomac.2014.11.028 Dong, 2017, Antimicrobial and antioxidant activities of Flammulina velutipes polysacchrides and polysacchride-iron(III) complex, Carbohydr. Polym., 165, 470, 10.1016/j.carbpol.2017.02.090 Cheng, 2019, Preparation and in vitro absorption studies of a novel polysaccharide-iron (III) complex from Flammulina velutipes, Int. J. Biol. Macromol., 132, 801, 10.1016/j.ijbiomac.2019.04.015 Dostal, 2015, Iron modulates butyrate production by a child gut microbiota in vitro, mBio, 6, e01453, 10.1128/mBio.01453-15 Virili, 2018, Gut microbiota and Hashimoto’s thyroiditis, Rev. Endocr. Metab. Disord., 19, 293, 10.1007/s11154-018-9467-y Raymond, 2003, Enterobactin: an archetype for microbial iron transport, Proc. Natl. Acad. Sci. U.S.A., 100, 3584, 10.1073/pnas.0630018100 Pajarillo, 2021, Trace metals and animal health: interplay of the gut microbiota with iron, manganese, zinc, and copper, Anim. Nutr, 7, 750, 10.1016/j.aninu.2021.03.005 Bhattacherjee, 2017, Transport of the glucosamine-derived browning product fructosazine (polyhydroxyalkylpyrazine) across the human intestinal Caco-2 cell monolayer: role of the hexose transporters, J. Agric. Food Chem, 65, 4642, 10.1021/acs.jafc.7b01611 Moradi, 2014, The transport and efflux of glycosylated luteinising hormone-releasing hormone analogues in Caco-2 cell model: contributions of glucose transporters and efflux systems, J. Pharm. Sci, 103, 3217, 10.1002/jps.24120 Wang, 2018, Characterization of a novel polysaccharide from Ganoderma lucidum and its absorption mechanism in Caco-2 cells and mice model, Int. J. Biol. Macromol., 118, 320, 10.1016/j.ijbiomac.2018.06.078 Li, 2019, Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia, Int. J. Biol. Macromol., 126, 747, 10.1016/j.ijbiomac.2018.12.214 Reddy, 2018, Impact of iron-enriched Aspergillus oryzae on iron bioavailability, safety, and gut microbiota in rats, J. Agric. Food Chem, 66, 6213, 10.1021/acs.jafc.8b01758 Dostal, 2012, Iron depletion and repletion with ferrous sulfate or electrolytic iron modifies the composition and metabolic activity of the gut microbiota in rats, J. Nutr., 142, 271, 10.3945/jn.111.148643 Yang, 2021, Study on the structure characterization and moisturizing effect of Tremella polysaccharide fermented from GCMCC5.39, Food Sci. Hum. Well., 10, 471, 10.1016/j.fshw.2021.04.009 Karamanos, 1988, Determination of iduronic acid and glucuronic acid in glycosaminoglycans after stoichiometric reduction and depolymerization using high-performance liquid chromatography and ultraviolet detection, Anal. Biochem., 172, 410, 10.1016/0003-2697(88)90463-0 Wu, 2021, Purification, structural elucidation, and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea, Food Sci. Hum. Well., 10, 63, 10.1016/j.fshw.2020.05.003 Fu, 2015, The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism, Eur. J. Pharm. Sci., 80, 1, 10.1016/j.ejps.2015.09.009 Li, 2021, Transport mechanism and subcellular localization of a polysaccharide from Cucurbia moschata across Caco-2 cells model, Int. J. Biol. Macromol., 182, 1003, 10.1016/j.ijbiomac.2021.04.107 Hansen, 1995, Wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits transcytosis in polarized epithelial cells, J. Biol. Chem., 270, 28425, 10.1074/jbc.270.47.28425 Wells, 1998, Cytochalasin-induced actin disruption of polarized enterocytes can augment internalization of bacteria, Infect. Immun., 66, 2410, 10.1128/IAI.66.6.2410-2419.1998 Raja, 2015, Identification of phlorizin binding domains in sodium-glucose cotransporter family: SGLT1 as a unique model system, Biochimie, 115, 187, 10.1016/j.biochi.2015.06.003 Scow, 2011, Absence of evidence of translocation of GLUT2 to the apical membrane of enterocytes in everted intestinal sleeves, J. Surg. Res, 167, 56, 10.1016/j.jss.2010.04.026 Wang, 2005, In vitro cytotoxicity of stealth liposomes co-encapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells, Biol. Pharm. Bull, 28, 822, 10.1248/bpb.28.822 Agarwal, 2007, Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor, Int. J. Pharm, 339, 139, 10.1016/j.ijpharm.2007.02.036 Gong, 2021, Structural characteristics and anti-inflammatory activity of UV/H2O2-treated algal sulfated polysaccharide from Gracilaria lemaneiformis, Food Chem. Toxicol., 152, 10.1016/j.fct.2021.112157 Wang, 2008, Molecular weight and proposed structure of the Angelica sinensis polysaccharide-iron complex, Chin. J. Chem., 26, 1068, 10.1002/cjoc.200890189 Li, 2020, Polysaccharide from the seeds of Plantago asiatica L. alleviates nonylphenol induced intestinal barrier injury by regulating tight junctions in human Caco-2 cell line, Int. J. Biol. Macromol., 164, 2134, 10.1016/j.ijbiomac.2020.07.259 Jin, 2018, In vitro and in vivo evaluation of 10-hydroxycamptothecin-loaded poly (n-butyl cyanoacrylate) nanoparticles prepared by miniemulsion polymerization, Colloids Surf. B, 162, 25, 10.1016/j.colsurfb.2017.11.029 Duizer, 1999, Effects of cadmium chloride on the paracellular barrier function of intestinal epithelial cell lines, Toxicol. Appl. Pharmacol., 155, 117, 10.1006/taap.1998.8589 Yu, 2019, Iron transport from ferrous bisglycinate and ferrous sulfate in DMT1-knockout human intestinal Caco-2 cells, Nutrients, 11, 485, 10.3390/nu11030485 Lu, 2020, Permeability and transport mechanism of trihexyphenidyl hydrochloride in Caco-2 cell monolayer model with a validated UPLC-MS/MS method, J. Pharm. Biomed. Anal., 178, 10.1016/j.jpba.2019.112924 Turco, 2011, Caco-2/TC7 cell line characterization for intestinal absorption: how reliable is this in vitro model for the prediction of the oral dose fraction absorbed in human?, Toxicol. in Vitro, 25, 13, 10.1016/j.tiv.2010.08.009 Xiang, 2020, Investigation of the uptake and transport of polysaccharide from Se-enriched Grifola frondosa in Caco-2 cells model, Int. J. Biol. Macromol., 158, 1330, 10.1016/j.ijbiomac.2020.04.160 Chun, 2005, Phenolic antioxidants from clonal oregano (Origanum vulgare) with antimicrobial activity against Helicobacter pylori, Process Biochem, 40, 809, 10.1016/j.procbio.2004.02.018 Tocchetti, 2018, Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-d-glucuronide in rat intestine and Caco-2 cells, Arch. Toxicol., 92, 777, 10.1007/s00204-017-2092-9 Jin, 2020, Molecular pharmacokinetic mechanism of the drug-drug interaction between genistein and repaglinide mediated by P-gp, Biomed. Pharmacother., 125, 10.1016/j.biopha.2020.110032 Jedlitschky, 2006, Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition, Expert Opin. Drug Metab. Toxicol., 2, 351, 10.1517/17425255.2.3.351 Smirnoff, 2018, Ascorbic acid metabolism and functions: a comparison of plants and mammals, Free Radical Biol. Med, 122, 116, 10.1016/j.freeradbiomed.2018.03.033 Abbaspour, 2014, Review on iron and its importance for human health, J. Res. Med. Sci, 19, 164 Salovaara, 2002, Organic acids influence iron uptake in the human epithelial cell line Caco-2, J. Agric. Food Chem, 50, 6233, 10.1021/jf0203040 Huo, 2018, N-mercapto acetyl-N′-octyl-O, N″-glycol chitosan as an efficiency oral delivery system of paclitaxel, Carbohydr. Polym., 181, 477, 10.1016/j.carbpol.2017.10.066 He, 2019, Effectiveness of AOS–iron on iron deficiency anemia in rats, RSC Adv, 9, 5053, 10.1039/C8RA08451C He, 2018, Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload, Food Funct, 9, 5390, 10.1039/C7FO02057K Chen, 2020, Total iron binding capacity (TIBC) is a potential biomarker of left ventricular remodelling for patients with iron deficiency anaemia, BMC Cardiovasc. Disord., 20, 4, 10.1186/s12872-019-01320-3 Mohammed, 2021, Effectiveness of inulin-type on the iron bioavailability in anemic female rats fed bio-yogurt, RSC Adv, 11, 1928, 10.1039/D0RA08873K Snms, 1974, Iron deficiency: impaired liver growth and DNA synthesis in the rat, Br. J. Haematol., 28, 453, 10.1111/j.1365-2141.1974.tb06664.x Linberg, 1998, Hemoglobin based oxygen carriers: how much methemoglobin is too much?, Artif. Cells Blood Substitutes Biotechnol, 26, 133, 10.3109/10731199809119772 Xiao, 2016, Effects of a tripeptide iron on iron-deficiency anemia in rats, Biol. Trace Elem. Res., 169, 211, 10.1007/s12011-015-0412-6 Acker, 2015, Lack of utility of repeat monitoring of hemoglobin and hematocrit following blunt solid organ injury in children, J. Trauma Acute Care Surg, 79, 991, 10.1097/TA.0000000000000791 El-Gendy, 2018, Value of soluble transferrin receptors and sTfR/log ferritin in the diagnosis of iron deficiency accompanied by acute infection, Indian J. Hematol. Blo., 34, 104, 10.1007/s12288-017-0836-6 Cullis, 2018, Investigation and management of a raised serum ferritin, Br. J. Haematol, 181, 331, 10.1111/bjh.15166 Kawabata, 2019, Transferrin and transferrin receptors update, Free Radical Biol. Med, 133, 46, 10.1016/j.freeradbiomed.2018.06.037 Feelders, 1998, Regulation of iron metabolism in the acute-phase response: interferon γ and tumour necrosis factor α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients, Eur. J. Clin. Invest., 28, 520, 10.1046/j.1365-2362.1998.00323.x Martín-González, 2020, Ferritin and liver fibrosis among patients with chronic hepatitis C virus infection, J. Trace Elem. Med. Biol, 61, 10.1016/j.jtemb.2020.126542 Khumalo, 1998, Serum transferrin receptors are decreased in the presence of iron overload, Clin. Chem., 44, 40, 10.1093/clinchem/44.1.40 Zhang, 2014, The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia, Food Funct, 5, 1381, 10.1039/c4fo00006d Angmo, 2017, Identification of guanosine 5′-diphosphate as potential iron mobilizer: preventing the hepcidin-ferroportin interaction and modulating the interleukin-6/STAT-3 pathway, Sci. Rep., 7, 40097, 10.1038/srep40097 Liu, 2012, Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia, J. Med. Food, 15, 923, 10.1089/jmf.2012.2231 Guo, 2011, Vitamin C protective role for alcoholic liver disease in mice through regulating iron metabolism, Toxicol. Ind. Health, 27, 341, 10.1177/0748233710387007 Chi, 2020, Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model, Phytomedicine, 67, 10.1016/j.phymed.2019.153157 Andoh, 2016, Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population, J. Clin. Biochem. Nutr., 59, 65, 10.3164/jcbn.15-152 Goldstein, 2015, Lactobacillus species: taxonomic complexity and controversial susceptibilities, Clin. Infect. Dis., 60, S98, 10.1093/cid/civ072 Liang, 2022, The effect of Flammulina velutipes polysaccharide on immunization analyzed by intestinal flora and proteomics, Front. Nutr., 9, 10.3389/fnut.2022.841230