Fish, <i>n</i>-3 fatty acids, cognition and dementia risk: not just a fishy tale

Proceedings of the Nutrition Society - Tập 81 Số 1 - Trang 27-40 - 2022
Rasha N.M. Saleh1, Anne Marie Minihane2,1
1Nutrition and Preventive Medicine, Norwich Medical School, BCRE, Rosalind Franklin Road, University of East Anglia (UEA), Norwich NR4 7UQ, UK
2Norwich Institute of Healthy Ageing, UEA, Norwich NR4 7UQ, UK

Tóm tắt

With growing and ageing populations, the incidence of dementia is expected to triple globally by 2050. In the absence of effective drugs to treat or reverse the syndrome, dietary approaches which prevent or delay disease onset have considerable population health potential. Prospective epidemiological studies and mechanistic insight from experimental models strongly support a positive effect of a high fish and long chain n-3 fatty acid (EPA and DHA) intake on a range of cognitive outcomes and dementia risk, with effect sizes equivalent to several years of ageing between the highest and lowest consumers. As reviewed here, an effect of EPA and DHA on neuroinflammation and oxylipin production is likely to in part mediate the neurophysiological benefits. However, randomised controlled trials (RCTs) with EPA and DHA supplementation have produced mixed findings. Insight into the likely modulators of response to intervention and factors which should be considered for future RCTs are given. Furthermore, the impact of APOE genotype on disease risk and response to EPA and DHA supplementation is summarised. The prevalence of dementia is several-fold higher in APOE4 females (about 13% Caucasian populations) relative to the general population, who are emerging as a subgroup who may particularly benefit from DHA intervention, prior to the development of significant pathology.

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Tài liệu tham khảo

10.1126/science.285.5431.1276

10.3945/ajcn.2009.29121

10.1016/S2213-8587(20)30148-0

10.1089/neu.2004.21.1457

10.1016/j.neurobiolaging.2018.05.017

10.3945/an.116.012187

10.1096/fj.201801412R

10.1016/j.cell.2015.10.067

10.1079/BJN2003901

10.1016/S1474-4422(17)30040-6

10.1016/0304-3940(91)90490-K

10.1093/aje/kwx330

10.1172/JCI122203

10.1017/S136898001800037X

10.1038/nm.2965

10.3390/nu8020099

10.3410/M4-13

10.1016/j.neubiorev.2014.11.008

10.1038/nrn3820

10.1016/S0140-6736(20)30367-6

10.1074/jbc.M703169200

10.1186/s13195-016-0194-x

10.1001/jamaneurol.2017.2188

10.1016/S1474-4422(18)30338-7

10.1001/jama.2010.1510

10.1007/s10571-017-0510-4

10.3390/nu10101413

10.1007/s12603-018-1052-2

10.1371/journal.pone.0046151

10.3945/ajcn.115.124081

10.1007/s00401-018-1920-1

10.1002/jnr.24327

10.1016/j.jalz.2013.12.024

10.1016/j.jnutbio.2016.03.002

10.3390/genes10030222

10.1007/s12035-018-1136-3

10.1096/fj.13-230276

10.1016/j.immuni.2014.02.009

10.1074/jbc.R800009200

10.1124/jpet.102.035048

10.1016/S1474-4422(12)70291-0

10.1016/j.bbalip.2014.08.006

10.4049/jimmunol.1402166

10.1001/jama.1997.03550160069041

10.1136/jnnp-2017-316176

10.1038/nrneurol.2012.263

10.3390/nu3050529

Shishtar, 2020, Long-term dietary flavonoid intake and change in cognitive function in the Framingham offspring cohort, Public Health Nutr, 23, 1

10.1038/srep41317

10.3945/ajcn.114.103507

Christie, 2020, Oxidation of polyunsaturated fatty acids to produce lipid mediators, Essays Biochem, 64, 401, 10.1042/EBC20190082

10.1371/journal.pbio.2006443

Wyss-Coray, 2006, Inflammation in Alzheimer disease: driving force, bystander or beneficial response?, Nat Med, 12, 1005

10.1096/fj.201900423R

10.1186/s12974-018-1151-3

10.1096/fj.202002621RR

10.1093/ajcn/83.6.1467S

Mitchell, 2011, Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells, J Neurochem, 117, 735

10.1001/jamaneurol.2016.4899

10.1093/ajcn/nqz114

10.1212/01.wnl.0000324268.45138.86

10.3945/an.114.007732

10.1016/j.ijdevneu.2005.11.014

10.1016/j.jalz.2016.02.010

1. Patterson, C (2018) World Alzheimer Report. Alzheimer's Disease International (ADI), London.

10.1016/j.atherosclerosis.2013.12.007

10.3389/fnagi.2015.00052

10.3390/ijms21176291

10.3389/fnut.2021.723813

10.1111/jnc.12640

10.3390/nu12030647

10.1182/blood-2010-07-273417

10.1093/jn/138.5.954

10.3233/JAD-201238

10.1038/s41582-018-0032-9

10.1136/bmj.m2269

10.3233/JAD-170248

10.1016/j.bbi.2018.07.025

10.1038/ng.3313

10.1124/pr.117.014092

10.3390/nu13030824

10.1038/nature13241

10.2174/156720511796391926

Klenk, 1952, Constitution of the unsaturated C20 and C22 fatty acids of the glycophosphatides of the brain, Hoppe Seylers Z Physiol Chem, 291, 104

Sinclair, 2019, Docosahexaenoic acid and the brain – what is its role?, Asia Pac J Clin Nutr, 28, 675

10.1093/ajcn/nqab174

10.3389/fnagi.2020.00150

10.1111/jnc.13943

127. SACN (2004) Advice on fish consumption: benefits and risks. London, The Stationary Office: Scientific Advisory Committee on Nutrition (UK Government).

10.1002/alz.12195

10.4049/jimmunol.0901809

25. WHO Guidelines (2019) Risk reduction of cognitive decline and dementia: Report No.: ISBN-13: 978-92-4-155054-3.

10.1042/BST20160474

10.1074/jbc.M305841200

10.1111/jnc.12392

4. ONS (2018) Deaths registered in England and Wales: 2017. In: Statistics OoN, editor.

10.1016/j.jalz.2011.03.003

10.1016/j.plefa.2017.06.006

10.1016/j.bbalip.2014.10.009

10.1212/WNL.0000000000009781

10.1212/WNL.0000000000000080

Strauss, 1992, Detection of interleukin-6 and α2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients, Lab Invest, 66, 223

10.1093/ajcn/87.2.449

10.3945/ajcn.2008.27037

10.1186/s12974-017-0939-x

Dani, 2018, Microglial activation correlates in vivo with both tau and amyloid in Alzheimer's disease, Brain, 141, 2740

3. Prince, M , Knapp, M , Guerchet, M (2014) Dementia UK: Update. Alzheimer's Society, with King's College London and the London School of Economics.

10.1016/S1474-4422(17)30332-0

10.1002/hbm.24782

126. ISSFAL (2004) Report of the Sub-Committee on Recommendations for Intake of Polyunsaturated Fatty Acids in Healthy Adults. International Society for the Study of Fatty Acids and Lipids.

10.1093/brain/awv288

10.1097/MCO.0000000000000440

10.1073/pnas.1817557115

10.1002/ana.410420514

10.1038/nature13324

10.1001/archneur.63.11.1545

10.1093/advances/nmaa053

10.1093/ajcn/nqx077

10.1016/j.plefa.2012.05.008

10.3390/ijms21165783

10.1074/jbc.R117.783076

10.1212/01.wnl.0000183148.34197.2e

10.1016/S0140-6736(17)31363-6

10.3390/nu13041074

10.1194/jlr.M800530-JLR200

10.1001/jama.2015.19451

10.1074/jbc.M300218200

10.1039/C7FO00403F

10.1017/S0007114513001268

10.1084/jem.20042031

10.1007/978-981-15-6082-8_14

10.1124/dmd.115.063339

10.3389/fimmu.2017.01464

10.1016/j.jalz.2010.01.013

10.1016/S1474-4422(18)30403-4

10.3109/00207454.2013.833510

10.1096/fj.201800200R

10.1016/S0753-3322(02)00253-6

10.1111/jnc.14722

10.1194/jlr.P012864

10.1073/pnas.1101073108

10.1002/alz.12172

10.1111/joim.12786

10.1073/pnas.1207022109

10.3945/ajcn.112.053371

10.1126/science.8346443

10.1016/0305-0491(76)90264-9

10.3390/antiox10060907

2018, Scientific Advisory Commission on Nutrition DoH

10.3233/JAD-2011-111217

10.3233/JAD-141335

10.1136/bmj.n1682

10.1016/j.bbi.2019.07.001

10.1016/j.neurobiolaging.2018.04.004

10.1016/j.mam.2017.12.004

10.1073/pnas.1807958115

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Proceedings of the Nutrition Society

Tập 81 Số 1

27-40

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