First report on the diagnosis and treatment of encephalic and urinary paracoccidioidomycosis in a cat

Journal of Feline Medicine and Surgery - Tập 12 - Trang 659-662 - 2010
Juan F. Gonzalez1, Nestor A. Montiel2, Rodrigo L. Maass3
1Facultad de Medicina Veterinaria, Universidad de Chile, Santiago, Chile
2University of California, Davis, Davis, CA 95616, United States
3Laboratorio de Medicina Experimental, Facultad de Medicina, Universidad de Valparaíso, La Troya esquina EL Convento, Casilla 295, San Felipe, Chile

Tóm tắt

A male Persian cat was presented with persistent fever, anorexia, weakness, hypopyon, nystagmus, and intention tremors. The hemogram showed severe neutropenia and laboratory analysis on cerebrospinal fluid (CSF) smears revealed abundant yeast cells compatible with Paracoccidioides brasiliensis. Urinalysis demonstrated persistent funguria and an increased urine protein-to-creatinine ratio (UPC) in addition to mild azotemia. Long-term therapy with oral fluconazole was effective in controlling the nervous system signs. Funguria was resolved with subcutaneous administration of diluted amphotericin B in a large volume of saline solution for a period of 12 weeks during the second year after initial diagnosis. Throughout 5 years of treatment, no adverse effects were observed and tolerance to the drugs was normal. Due to development of progressive uremic syndrome the animal was euthanased. To the best of our knowledge, this report is the first clinical case described of a nervous and urinary system infection caused by the P brasiliensis in a cat.

Tài liệu tham khảo

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Thông tin xuất bản

Journal of Feline Medicine and Surgery

Tập 12

659-662

Thông tin tác giả