First description of a multisystemic and lethal SARS-CoV-2 variant of concern P.1 (Gamma) infection in a FeLV-positive cat

Virology Journal - Tập 19 - Trang 1-8 - 2022
Rodrigo Lima Carneiro1, Jéssica Pires Farias2,3, Josilene Ramos Pinheiro2,4, Jackson Farias1, André Carloto Vielmo5, Alexander Birbrair6,7,8, Aline Belmok9, Fernando Lucas Melo9, Bergmann Morais Ribeiro9, Gepoliano Chaves10, Paloma Oliveira Vidal2, Wilson Barros Luiz4, Jaime Henrique Amorim2,3,4,5
1Department of Human Sciences, State University of Bahia, Salvador, Brazil
2Laboratory of Infectious Agents and Vectors (LAIVE), Center of Biological Sciences and Health, Federal University of Western Bahia, Morada Nobre, Barreiras, Brazil
3Multicentric Graduate Program in Biochemistry and Molecular Biology, Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras, Brazil
4Graduate Program in Biology and Biotechnology of Microorganisms, Department of Biological Sciences, State University of Santa Cruz, Ilhéus, Brazil
5Graduate Program in Investigative Pathology, Center of Biological Sciences and Health, Federal University of Western Bahia, Barreiras, Brazil
6Department of Dermatology, University of Wisconsin-Madison, Madison, USA
7Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil
8Department of Radiology, Columbia University Medical Center, New York, USA
9Laboratory of Baculoviruses, University of Brasília, Brasília, Brazil
10Department of Pediatrics, University of Chicago, Chicago, USA

Tóm tắt

Phylogenetic studies indicate bats as original hosts of SARS-CoV-2. However, it remains unclear whether other animals, including pets, are crucial in the spread and maintenance of COVID-19 worldwide. In this study, we analyzed the first fatal case of a SARS-CoV-2 and FeLV co-infection in an eight-year-old male cat. We carried out a clinical evaluation and several laboratory analyses. As main results, we observed an animal presenting severe acute respiratory syndrome and lesions in several organs, which led to the animal’s death. RT-qPCR analysis showed a SARS-CoV-2 as the causative agent. The virus was detected in several organs, indicating a multisystemic infection. The virus was found in a high load in the trachea, suggesting that the animal may have contribute to the transmission of the virus. The whole-genome sequencing revealed an infection by SARS-CoV-2 Gamma VOC (P.1), and any mutations indicating host adaptation were observed. Our data show that FeLV-positive cats are susceptible to SARS-CoV-2 infection and raise questions about the potential of immunocompromised FeLV-positive cats to act as a reservoir for SARS-CoV-2 new variants.

Tài liệu tham khảo

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Virology Journal

Tập 19

1-8

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