Fine structural morphology of identified X- and Y-cells in the cat's lateral geniculate nucleus

The Royal Society - Tập 221 Số 1225 - Trang 411-436 - 1984
James R. Wilson1,2, Neelanjan Bose1,2, S. Murray Sherman1,2
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Tóm tắt

Four physiologically identified neurons in the A laminae of the cat’s dorsal lateral geniculate nucleus were filled with horseradish peroxidase and studied using the electron microscope. Two were X-cells and two were Y-cells. Each had electrophysiological properties appropriate for its X- or Y-cell class, and each also had an axon that projected into the optic radiation, indicative of a geniculocortical relay cell. Representative samples from about 10% of each neuron’s entire dendritic arbor (proximal and distal) were taken to obtain an estimate of the types and distributions of synapses contacting these arbors. One X-cell had a cytoplasmic laminar body, but there were no other significant cytological differences seen among the neurons. Common to each of the neurons were the following synaptic features: (i) retinal terminals (r. l. p.) were mostly or entirely restricted to proximal dendrites or dendritic appendages (< 100 μm from the soma). These terminals constituted about 15-25% of the synapses on the proximal dendrites, (ii) Terminals with flattened or pleomorphic synaptic vesicles (f. terminals) were predominant on the proximal dendrites (30-55% of the total synapses for that region) and were mainly located near the retinal terminals. A smaller percentage (10-20%) were also distributed onto the distal dendrites, (iii) Small terminals with round synaptic vesicles (r. s. d.), many presumably having a cortical origin, predominated (60-80%) on distal dendrites (> 100 μm), but also formed a large proportion (40-70%) of the synapses on the intermediate (50-150 μm) dendrites. Total synaptic contacts for one X-cell and one Y-cell were estimated at about 4000 and 5000, respectively. The major fine structural differences observed between X- and Y-cells were almost entirely related to the retinal afferents. First, the retinal synapses for X-cells were mostly made on to dendritic appendages (spines, etc.), whereas Y-cells had most of their retinal synapses onto the shafts of primary and proximal secondary dendrites (that is, near branch points). Second, the retinal terminals that contacted X-cell dendrites nearly always formed triadic arrangements that included nearby f. terminals, but those on Y-cells rarely did so. Finally, the main type of f. terminals associated with X-cells were morphologically different from most of those associated with the Y-cells, and this also related directly to the triadic arrangements; that is, f. terminals in the triadic arrangements were morphologically distinguishable from f. terminals that did not participate in triadic arrangements. Even though the present sample is quite small, these morphological differences between X- and Y-cells indicate that they might be the synaptic basis for some of the differential processing of information occurring for the two cell types in the lateral geniculate nucleus.

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Tài liệu tham khảo

10.1016/0006-8993(82)90886-1

1978, Axonal branching o f functionally identified neurones in the lateral geniculate body o f th e cat. Neurosci, Lett., 1, 156

10.1016/0006-8993(82)90730-2

10.1016/0006-8993(78)90084-7

10.1152/jn.1979.42.1.274

Burke W., 1978, E xtraretinal influences on the lateral geniculate nucleus, Rev. Physiol Biochem. Pharmacol., 80, 105, 10.1007/3540084665_3

Chang J., 1952, Cortical neurons w ith particular reference to the apical dendrites. Cold Spring Harb. Sym. quant, Biol., 17, 189

10.1113/jphysiol.1971.sp009581

10.1007/BF00236402

Colonnier M. & Guillery R . W . 1964 Synaptic organization in the lateral geniculate nucleus o f the m onkey. Z .Zellforsch. 62 333-355.

10.1016/0166-2236(82)90020-0

D iam ond J. Gray E. G. & Y asargil G. M. 1970 The function of the dendritic spine: an hypothesis. In Excitatory synaptic mechanisms (ed. P. Anderson & J. K. S. Janses) pp. 213-222. Oslo: U niversitetsforlag.

Dreher B., 1979, Properties o f neurones in ca t's dorsal lateral geniculate n u cleu s: a com parison betw een m edial interlam inar and lam inated parts o f the cat. J. comp, Neurol., 183, 47

10.1152/jn.1977.40.2.410

Enroth-Cugell C., 1966, The contrast sen sitivity o f retinal ganglion cells o f the cat, J. Physiol. Bond., 187, 516

Th, 1976, Q uantitative studies o f intracellular postsynaptic potentials in the lateral geniculate nucleus o f th e cat w ith respect to optic tract stim ulus response latencies, Expl Brain Res., 25, 469

10.1016/0006-8993(70)90287-8

Peters A., 1972, The synaptic glom erulus and the intrinsic neurons in the dorsal lateral geniculate nucleus o f the cat. J. comp, Neurol., 144, 285

10.1152/jn.1981.46.1.80

Ferster D., 1978, The axonal arborizations o f lateral geniculate neurons in the striate cortex o f the cat. J. comp, Neurol., 182, 923

10.1016/0006-8993(76)90018-4

10.1016/0006-8993(81)90568-0

Gilbert C. D ., 1975, The projection o f cells in different layers of the ca t's visual cortex. J. comp, Neurol., 163, 81

Guillery R ., 1966, A stu d y o f Golgi preparations from the dorsal lateral geniculate nucleus o f the adult cat. J.comp, Neurol., 128, 21

Guillery R ., 1967, P atterns o f fiber degeneration in the dorsal lateral geniculate nucleus o f the cat follow ing lesions in th e visu al cortex. J. comp, Neurol., 130, 197

10.1007/BF00321474

10.1016/0042-6989(71)90041-1

10.1007/BF00335403

10.1016/0006-8993(74)91024-5

10.1126/science.165.3889.194

10.1113/jphysiol.1976.sp011594

10.1113/jphysiol.1976.sp011595

10.1152/jn.1972.35.4.518

10.1016/0006-8993(72)90516-1

Ide L., 1982, The fine structure o f the perigeniculate nucleus in th e cat. J. comp, Neurol., 210, 317

Jones E ., 1975, Som e aspects o f the organization o f the thalam ic reticular com plex. J. comp, Neurol., 162, 285

10.1098/rspb.1969.0018

1978, C ytoplasm ic lam inated bodies in the lateral geniculate nucleus o f norm al and dark reared cats. J. comp, Neurol., 178, 469

10.2170/jjphysiol.21.307

1983, A theoretical analysis o f electrical properties o f spines, Proc. R. Soc. Lond. B, 218, 255

10.1098/rstb.1982.0084

10.1152/jn.1980.43.2.520

10.1016/0042-6989(80)90115-7

10.1007/BF00968547

1973, Synaptic patterns in the visual cortex o f the cat and m onkey. Electron m icroscopy o f Golgi preparations. J. comp, Neurol., 150, 53

Ferster D ., 1977, R elay cell classes in the lateral geniculate nucleus o f the cat and th e effects o f visual deprivation. J. comp, Neurol., 172, 563

10.1016/0006-8993(76)90002-0

10.1016/0006-8993(73)90252-7

10.1007/BF01097191

10.1016/0006-8993(82)90885-X

10.1523/JNEUROSCI.02-02-00256.1982

10.1152/jn.1967.30.1.1

10.1016/0306-4522(81)90102-0

Morales R . D uncan R . & R eh m et R . 1964 A distinctive lam inated cytoplasm ic body in the lateral geniculate neurons o f th e cat. J. ultra sRes. 10 116-123.

10.1016/0306-4522(83)90060-X

10.1016/0006-8993(80)91136-1

10.1007/BF00237322

Pasik P . P asik T. H am ori J . & Szentagothai J . 1973 Golgi typ e II interneurons in the neuronal circuit o f th e m onkey lateral geniculate nucleus Expl Brain Res. 17 18-34.

10.1002/aja.1001270402

Peters A . P alay S. L. & W ebster H . 1976 Thefine structure of the nervous system. P hilad elp h ia: W . B . Saunders.

1973, The structure o f the dorsal lateral geniculate nucleus in the m ouse. A Golgi and electron m icroscopic stu d y. J. comp, Neurol., 150, 303

R ail W . 1977 Core conductor theory and cable properties o f neurons. In Handbook ofphysiology (ed. E . K andel and S. Geiger) pp. S ociety.

9 -9 7 . W ashington: A m erican P hysiological

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The Royal Society

Tập 221 Số 1225

411-436

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