Finding one's way in proteomics: a protein species nomenclature

Springer Science and Business Media LLC - Tập 3 - Trang 1-10 - 2009
Hartmut Schlüter1, Rolf Apweiler2, Hermann-Georg Holzhütter3, Peter R Jungblut4
1University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
2The EMBL Outstation-The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Great Britain
3Charité Berlin, Institut für Biochemie, Berlin, Germany
4Max Planck Institute for Infection Biology, Berlin, Germany

Tóm tắt

Our knowledge of proteins has greatly improved in recent years, driven by new technologies in the fields of molecular biology and proteome research. It has become clear that from a single gene not only one single gene product but many different ones - termed protein species - are generated, all of which may be associated with different functions. Nonetheless, an unambiguous nomenclature for describing individual protein species is still lacking. With the present paper we therefore propose a systematic nomenclature for the comprehensive description of protein species. The protein species nomenclature is flexible and adaptable to every level of knowledge and of experimental data in accordance with the exact chemical composition of individual protein species. As a minimum description the entry name (gene name + species according to the UniProt knowledgebase) can be used, if no analytical data about the target protein species are available.

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