Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

DiCostanzo, D., Rosen, P. P., Gareen, I., Franklin, S. & Lesser, M. Prognosis in infiltrating lobular carcinoma. An analysis of “classical” and variant tumors. Am. J. Surg. Pathol. 14, 12–23 (1990).

Yamamoto, E., Kohama, G., Sunakawa, H., Iwai, M. & Hiratsuka, H. Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity. Cancer 51, 2175–2180 (1983).

Macpherson, I. R. et al. p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene 26, 5214–5228 (2007).

Wolf, K. et al. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature Cell Biol. 9, 893–904 (2007).

Nystrom, M. L. et al. Development of a quantitative method to analyse tumour cell invasion in organotypic culture. J. Pathol. 205, 468–475 (2005).

Costea, D. E., Kulasekara, K., Neppelberg, E., Johannessen, A. C. & Vintermyr, O. K. Species-specific fibroblasts required for triggering invasiveness of partially transformed oral keratinocytes. Am. J. Pathol. 168, 1889–1897 (2006).

Cukierman, E. Cell migration analyses within fibroblast-derived 3-D matrices. Methods Mol. Biol. 294, 79–93 (2005).

Wyckoff, J. B., Pinner, S. E., Gschmeissner, S., Condeelis, J. S. & Sahai, E. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr. Biol. 16, 1515–1523 (2006).

Egeblad, M., Littlepage, L. E. & Werb, Z. The fibroblastic coconspirator in cancer progression. Cold Spring Harb. Symp. Quant. Biol. 70, 383–388 (2005).

Kim, A., Lakshman, N. & Petroll, W. M. Quantitative assessment of local collagen matrix remodeling in 3-D culture: the role of Rho kinase. Exp. Cell Res. 312, 3683–3692 (2006).

Lakshman, N., Kim, A., Bayless, K. J., Davis, G. E. & Petroll, W. M. Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture. Cell Motil. Cytoskeleton 64, 434–445 (2007).

Rhee, S. & Grinnell, F. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. J. Cell Biol. 172, 423–432 (2006).

Sahai, E. & Olson, M. F. Purification of TAT-C3 exoenzyme. Methods Enzymol. 406, 128–140 (2006).

Berdeaux, R. L., Diaz, B., Kim, L. & Martin, G. S. Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J. Cell Biol. 166, 317–323 (2004).

Hegerfeldt, Y., Tusch, M., Brocker, E. B. & Friedl, P. Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res. 62, 2125–2130 (2002).

Danen, E. H. et al. Integrins control motile strategy through a Rho-cofilin pathway. J. Cell Biol. 169, 515–526 (2005).

White, D. P., Caswell, P. T. & Norman, J. C. α v β3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J. Cell Biol. 177, 515–525 (2007).

Ren, X. D., Kiosses, W. B. & Schwartz, M. A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578–585 (1999).

Wilkinson, S., Paterson, H. F. & Marshall, C. J. Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nature Cell Biol. 7, 255–261 (2005).

Thiery, J. P. Epithelial–mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442–454 (2002).

De Wever, O. et al. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J. 18, 1016–1018 (2004).

Bhowmick, N. A., Neilson, E. G. & Moses, H. L. Stromal fibroblasts in cancer initiation and progression. Nature 432, 332–337 (2004).

Orimo, A. & Weinberg, R. A. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5, 1597–1601 (2006).

Ronnov-Jessen, L., Petersen, O. W., Koteliansky, V. E. & Bissell, M. J. The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. J. Clin. Invest. 95, 859–873 (1995).

Kaariainen, E. et al. Switch to an invasive growth phase in melanoma is associated with tenascin-C, fibronectin, and procollagen-I forming specific channel structures for invasion. J. Pathol. 210, 181–191 (2006).

Provenzano, P. P. et al. Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med. 4, 38 (2006).

Bajenoff, M. et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989–1001 (2006).

Kitamura, T. et al. SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nature Genet. 39, 467–475 (2007).

Mackenzie, I. C. Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa. J. Oral Pathol. Med. 33, 71–78 (2004).

Cukierman, E., Pankov, R., Stevens, D. R. & Yamada, K. M. Taking cell-matrix adhesions to the third dimension. Science 294, 1708–1712 (2001).

Hooper, S., Marshall, J. F. & Sahai, E. Tumor cell migration in three dimensions. Methods Enzymol. 406, 625–643 (2006).

Goulimari, P. et al. Gα12/13 is essential for directed cell migration and localized Rho–Dia1 function. J. Biol. Chem. 280, 42242–42251 (2005).