Ferulic acid improves lipid and glucose homeostasis in high‐fat diet‐induced obese mice

Clinical and Experimental Pharmacology and Physiology - Tập 43 Số 2 - Trang 242-250 - 2016
Jarinyaporn Naowaboot1, Pritsana Piyabhan2, Narongsuk Munkong3, Wason Parklak3, Patchareewan Pannangpetch4
1Division of Pharmacology, Thammasat University (Rangsit Campus), Pathum Thani, Thailand
2Division of Physiology; Department of Preclinical Science; Thammasat University (Rangsit Campus); Pathum Thani Thailand
3Graduate Academy; Faculty of Medicine; Thammasat University (Rangsit Campus); Pathum Thani Thailand
4Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Tóm tắt

SummaryFerulic acid (FA) is a plant phenolic acid that has several pharmacological effects including antihyperglycaemic activity. Thus, the objective of this study is to investigate the effect of FA on glucose and lipid metabolism in high‐fat diet (HFD)‐induced obese mice. Institute for Cancer Research (ICR) mice were fed a HFD (45 kcal% fat) for 16 weeks. At the ninth week of induction, the obese mice were orally administered with daily FA doses of 25 and 50 mg/kg for the next eight weeks. The results show that FA significantly reduced the elevated blood glucose and serum leptin levels, lowered the insulin resistance, and increased the serum adiponectin level. Moreover, serum lipid level, and liver cholesterol and triglyceride accumulations were also reduced. The histological examination showed clear evidence of a decrease in the lipid droplets in liver tissues and smaller size of fat cells in the adipose tissue in the obese mice treated with FA. Interestingly, FA reduced the expression of hepatic lipogenic genes such as sterol regulatory element‐binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl‐CoA carboxylase (ACC). It could also up‐regulate hepatic carnitine palmitoyltransferase 1a (CPT1a) gene and peroxisome proliferator‐activated receptor alpha (PPARα) proteins. The FA treatment was also found to suppress the protein expressions of hepatic gluconeogenic enzymes, phosphoenolpyruvate carboxylase (PEPCK) and glucose‐6‐phosphatase (G6Pase). In conclusion, the findings of this study demonstrate that FA improves the glucose and lipid homeostasis in HFD‐induced obese mice probably via modulating the expression of lipogenic and gluconeogenic genes in liver tissues.

Từ khóa


Tài liệu tham khảo

10.1016/S0092-8674(01)00240-9

10.1038/414799a

10.1210/er.2008-0009

10.1172/JCI34275

10.1172/JCI0215593

10.1038/nm1025

10.1073/pnas.91.19.9151

10.1074/jbc.273.47.31615

10.1021/jf011348w

10.1016/j.foodchem.2013.04.132

10.1007/s12020-012-9868-8

10.1016/j.bbrc.2014.08.079

10.1016/j.ejphar.2015.04.043

10.1016/j.ejphar.2012.05.019

10.1111/j.1750-3841.2010.01907.x

10.1007/s00592-003-0099-6

10.1016/j.lfs.2013.03.015

10.1016/j.tins.2013.05.003

10.1038/oby.2006.319

10.1210/en.2013-1218

10.1016/j.endonu.2011.11.007

10.1080/13813450903079314

10.2337/dc09-S302

10.1016/j.bbalip.2011.10.016

10.1210/en.2005-1536

10.1210/en.2005-1132

10.1152/ajpgi.00521.2005

10.1172/JCI200422422

10.1007/s11010-005-9053-y

10.1016/S1097-2765(05)00010-9

10.1016/j.fct.2013.07.048

10.1177/0148607113486931

10.1016/j.abb.2009.03.004

10.1074/jbc.M306238200

10.1074/jbc.M601277200

10.1016/j.jep.2009.09.052

10.1007/s00125-003-1228-z

10.1007/s00125-002-0873-y

10.1194/jlr.M004929

10.1152/ajpendo.00203.2004

Abel ED, 2010, Free fatty acid oxidation in insulin resistance and obesity, Heart Metab., 48, 5

10.1038/sj.ijo.0802904

10.1210/endo.143.3.8662

10.2337/diabetes.50.9.2094

10.1159/000308466

10.1186/s13618-014-0022-y

10.1002/ptr.3152

10.2337/diabetes.50.5.1158

Thông tin
Thông tin xuất bản

Clinical and Experimental Pharmacology and Physiology

Tập 43 Số 2

242-250

Thông tin tác giả