Fertilität bei Männern über 40 Jahren

M. Zitzmann1
1Centrum für Reproduktionsmedizin und Andrologie, Universitätsklinikum Münster, Münster, Deutschland

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Tatone C (2008) Oocyte senescence: a firm link to age-related female subfertility. Gynecol Endocrinol 24:59–63

Balasch J (2010) Ageing and infertility: an overview. Gynecol Endocrinol 26:855–860

Sartorius GA, Nieschlag E (2010) Paternal age and reproduction. Hum Reprod Update 16:65–79

Bray I, Gunnell D, Davey Smith G (2006) Advanced paternal age: how old is too old? J Epidemiol Community Health 60:851–853

Wiener-Megnazi Z, Auslender R, Dirnfeld M (2012) Advanced paternal age and reproductive outcome. Asian J Androl 14:69–76

Shindel AW, Nelson CJ, Naughton CK et al (2008) Sexual function and quality of life in the male partner of infertile couples: prevalence and correlates of dysfunction. J Urol 179:1056–1059

Wu FC, Tajar A, Beynon JM et al (2010) Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 363:123–135

Corona G, Lee DM, Forti G et al (2010) Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS). J Sex Med 7:1362–1380

Han TS, Tajar A, O’Neill TW et al (2011) Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study. Eur J Endocrinol 164:1003–1011

Lindau ST, Schumm LP, Laumann EO et al (2007) A study of sexuality and health among older adults in the United States. N Engl J Med 357:762–774

Lee DM, Tajar A, Ravindrarajah R et al (2013) Frailty and sexual health in older European men. J Gerontol A Biol Sci Med Sci 68:837–844

Nicolosi A, Buvat J, Glasser DB et al (2006) Sexual behaviour, sexual dysfunctions and related help seeking patterns in middle-aged and elderly Europeans: the global study of sexual attitudes and behaviors. World J Urol 24:423–428

McVary KT (2007) Clinical practice. Erectile dysfunction. N Engl J Med 357:2472–2481

Luo YH, Hou Q, Zheng SB (2012) Meta-analysis of dapoxetine on demand in the treatment of premature ejaculation. Zhonghua Nan Ke Xue 18:930–935

Rago R, Salacone P, Caponecchia L et al (2012) Effect of vardenafil on semen parameters in infertile men: a pilot study evaluating short-term treatment. J Endocrinol Invest 35:897–900

Traish AM, Hassani J, Guay AT et al (2011) Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med 8:872–884

Amory JK, Wang C, Swerdloff RS et al (2007) The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men. J Clin Endocrinol Metab 92:1659–1665

Dakouane Giudicelli M, Serazin V, Le Sciellour CR et al (2008) Increased achondroplasia mutation frequency with advanced age and evidence for G1138A mosaicism in human testis biopsies. Fertil Steril 89:1651–1656

Handelsman DJ, Staraj S (1985) Testicular size: the effects of aging, malnutrition, and illness. J Androl 6:144–151

Kidd SA, Eskenazi B, Wyrobek AJ (2001) Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75:237–248

Hellstrom WJ, Overstreet JW, Sikka SC et al (2006) Semen and sperm reference ranges for men 45 years of age and older. J Androl 27:421–428

Sloter E, Schmid TE, Marchetti F et al (2006) Quantitative effects of male age on sperm motion. Hum Reprod 21:2868–2875

Rolf C, Behre HM, Nieschlag E (1996) Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 19:135–142

Jensen TK, Andersson AM, Jorgensen N et al (2004) Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 82:863–870

Hammoud AO, Wilde N, Gibson M et al (2008) Male obesity and alteration in sperm parameters. Fertil Steril 90:2222–2225

Rolf C, Kenkel S, Nieschlag E (2002) Age-related disease pattern in infertile men: increasing incidence of infections in older patients. Andrologia 34:209–217

Gagnon C, Lamirande E de (2006) Controls of sperm motility. In: De Jonge CC, Barratt CLR (Hrsg) The sperm cell: production, maturation, fertilization, regeneration. Cambridge University Press, Cambridge, S 108–133

Aitken RJ, Nixon B, Lin M et al (2007) Proteomic changes in mammalian spermatozoa during epididymal maturation. Asian J Androl 9:554–564

Amann RP (2008) The cycle of the seminiferous epithelium in humans: a need to revisit? J Androl 29:469–487

Mahmoud AM, Goemaere S, El-Garem Y et al (2003) Testicular volume in relation to hormonal indices of gonadal function in community-dwelling elderly men. J Clin Endocrinol Metab 88:179–184

Nieschlag E, Lammers U, Freischem CW et al (1982) Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab 55:676–681

Baccarelli A, Morpurgo PS, Corsi A et al (2001) Activin A serum levels and aging of the pituitary-gonadal axis: a cross-sectional study in middle-aged and elderly healthy subjects. Exp Gerontol 36:1403–1412

Zitzmann M (2009) Testosterone deficiency, insulin resistance and the metabolic syndrome. Nat Rev Endocrinol 12:673–681

Kelly DM, Jones TH (2013) Testosterone: a metabolic hormone in health and disease. J Endocrinol 217:R25–R45

Ford WC, North K, Taylor H et al (2000) Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 15:1703–1708

La Rochebrochard E de, Mouzon J de, Thepot F, Thonneau P (2006) Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France. Fertil Steril 85:1420–1424

La Rochebrochard E de, McElreavey K, Thonneau P (2003) Paternal age over 40 years: the ‚amber light‘ in the reproductive life of men? J Androl 24:459–465

Hassan MA, Killick SR (2003) Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Fertil Steril 79:1520–1527

Dain L, Auslander R, Dirnfeld M (2011) The effect of paternal age on assisted reproduction outcome. Fertil Steril 95:1–8

Alio AP, Salihu HM, McIntosh C et al (2012) The effect of paternal age on fetal birth outcomes. Am J Mens Health 6:427–435

Martin RH (2006) Meiotic chromosome abnormalities in human spermatogenesis. Reprod Toxicol 22:142–147

Griffin DK, Abruzzo MA, Millie EA et al (1995) Non-disjunction in human sperm: evidence for an effect of increasing paternal age. Hum Mol Genet 4:2227–2232

Buwe A, Guttenbach M, Schmid M (2005) Effect of paternal age on the frequency of cytogenetic abnormalities in human spermatozoa. Cytogenet Genome Res 111:213–228

Fonseka KG, Griffin DK (2011) Is there a paternal age effect for aneuploidy? Cytogenet Genome Res 33:280–291

Oeseburg H, Boer RA de, Gilst WH van, Harst P van der (2010) Telomere biology in healthy aging and disease. Pflugers Arch 459:259–268

Martinez P, Blasco MA (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 11:161–176

Eisenberg DT (2011) An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. Am J Hum Biol 23:149–167

Unryn BM, Cook LS, Riabowol KT (2005) Paternal age is positively linked to telomere length of children. Aging Cell 4:97–101

Meyer T de, Rietzschel ER, Buyzere ML de et al (2007) Asklepios investigators. Paternal age at birth is an important determinant of offspring telomere length. Hum Mol Genet 16:3097–3102

Nordfjäll K, Larefalk A, Lindgren P et al (2005) Telomere length and heredity: indications of paternal inheritance. Proc Natl Acad Sci U S A 102:16374–16378

Njajou OT, Cawthon RM, Damcott CM et al (2007) Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A 104:12135–12139

Kimura M, Cherkas LF, Kato BS et al (2008) Offspring’s leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genet 4:e37

Aston KI, Hunt SC, Susser E et al (2012) Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans. Mol Hum Reprod 18:517–522

Singh NP, Muller CH, Berger RE (2003) Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil Steril 80:1420–1430

Hemminki K, Kyyronen P, Vaittinen P (1999) Parental age as a risk factor of childhood leukemia and brain cancer in offspring. Epidemiology 10:271–275

Spano M, Bonde JP, Hjollund HI et al (2000) Sperm chromatin damage impairs human fertility. The Danish first pregnancy planner study team. Fertil Steril 73:43–50

Lopes S, Sun JG, Jurisicova A et al (1998) Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. Fertil Steril 69:528–532

Zini A, Libman J (2006) Sperm DNA damage: clinical significance in the era of assisted reproduction. CMAJ 175:495–500

Smith TB, De Iuliis G, Lord T, Aitken RJ (2013) The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line. Reproduction 146:253–262

Vagnini L, Baruffi RL, Mauri AL et al (2007) The effects of male age on sperm DNA damage in an infertile population. Reprod Biomed Online 15:514–519

Katz-Jaffe MG, Parks J, McCallie B, Schoolcraft WB (2013) Aging sperm negatively impacts in vivo and in vitro reproduction: a longitudinal murine study. Fertil Steril 100:262–268

Penrose LS (1955) Parental age and mutation. Lancet 269:312–313

Jones KL, Smith DW, Harvey MA et al (1975) Older paternal age and fresh gene mutation: data on additional disorders. J Pediatr 86:84–88

Crow JF (2000) The origins, patterns and implications of human spontaneous mutation. Nat Rev Genet 1:40–47

Goriely A, McVean GA, Rojmyr M et al (2003) Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line. Science 301:643–646

Tiemann-Boege I, Navidi W, Grewal R et al (2002) The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A 99:14952–14957

Tarin JJ, Brines J, Cano A (1998) Long-term effects of delayed parenthood. Hum Reprod 13:2371–2376

Crow JF (1997) The high spontaneous mutation rate: is it a health risk? Proc Natl Acad Sci U S A 94:8380–8386

Inoue M, Kurihara T, Yamashita M, Tatsumi K (1993) Effects of treatment with methyl methanesulfonate during meiotic and postmeiotic stages and maturation of spermatozoa in mice. Mutat Res 294:179–186

Kelso KA, Redpath A, Noble RC, Speake BK (1997) Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. J Reprod Fertil 109:1–6

Matsuda Y, Tobari I, Maemori M, Seki N (1989) Mechanism of chromosome aberration induction in the mouse egg fertilized with sperm recovered from postmeiotic germ cells treated with methyl methanesulfonate. Mutat Res 214:165–180

Curley JP, Mashoodh R, Champagne FA (2011) Epigenetics and the origins of paternal effects. Horm Behav 59:306–314

Jenkins TG, Aston KI, Cairns BR, Carrell DT (2013) Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril 100:945–951

Gosden R, Trasler J, Lucifero D, Faddy M (2003) Rare congenital disorders, imprinted genes, and assisted reproductive technology. Lancet 361:1975–1977

Marques CJ, Carvalho F, Sousa M, Barros A (2004) Genomic imprinting in disruptive spermatogenesis. Lancet 363:1700–1702

Jenkins TG, Carrell DT (2012) The sperm epigenome and potential implications for the developing embryo. Reproduction 143:727–734

La Salle S, Trasler JM (2006) Epigenetic patterning in male germ cells: importance of DNA methylation to progeny outcome. In: De Jonge CC, Barratt CLR (Hrsg) The sperm cell: production, maturation, fertilization, regeneration. Cambridge University Press, Cambridge

Oakes CC, Smiraglia DJ, Plass C et al (2003) Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats. Proc Natl Acad Sci U S A 100:1775–1780

Perrin MC, Brown AS, Malaspina D (2007) Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia. Schizophr Bull 33:1270–1273

Anagnostou E, Taylor MJ (2011) Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here. Mol Autism 2:4

Reichenberg A, Gross R, Weiser M et al (2006) Advancing paternal age and autism. Arch Gen Psychiatry 63:1026–1032

Buizer-Voskamp JE, Laan W, Staal WG et al (2011) Paternal age and psychiatric disorders: findings from a Dutch population registry. Schizophr Res 129:128–132

Alter MD, Kharkar R, Ramsey KE et al (2011) Autism and increased paternal age related changes in global levels of gene expression regulation. PLoS One 6:e16715

Frans EM, Sandin S, Reichenberg A et al (2013) Autism risk across generations: a population-based study of advancing grandpaternal and paternal age. JAMA Psychiatry 70:516–521