Feature‐space clustering for fMRI meta‐analysis

Human Brain Mapping - Tập 13 Số 3 - Trang 165-183 - 2001
Cyril Goutte1, Lars Kai Hansen2, Matthew G. Liptrot2, Egill Rostrup3
1INRIA Rhône Alpes, Montbonnot, France
2Department of Mathematical Modeling, Technical University of Denmark, Lyngby, Denmark
3Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark

Tóm tắt

Abstract

Clustering functional magnetic resonance imaging (fMRI) time series has emerged in recent years as a possible alternative to parametric modeling approaches. Most of the work so far has been concerned with clustering raw time series. In this contribution we investigate the applicability of a clustering method applied to features extracted from the data. This approach is extremely versatile and encompasses previously published results [Goutte et al.,1999] as special cases. A typical application is in data reduction: as the increase in temporal resolution of fMRI experiments routinely yields fMRI sequences containing several hundreds of images, it is sometimes necessary to invoke feature extraction to reduce the dimensionality of the data space. A second interesting application is in the meta‐analysis of fMRI experiment, where features are obtained from a possibly large number of single‐voxel analyses. In particular this allows the checking of the differences and agreements between different methods of analysis. Both approaches are illustrated on a fMRI data set involving visual stimulation, and we show that the feature space clustering approach yields nontrivial results and, in particular, shows interesting differences between individual voxel analysis performed with traditional methods. Hum. Brain Mapping 13:165–183, 2001. © 2001 Wiley‐Liss, Inc.

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