Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

American Association for the Advancement of Science (AAAS) - Tập 330 Số 6005 - Trang 841-845 - 2010
Florent Ginhoux1,2, Melanie Greter1, Marylène Leboeuf1, Sayan Nandi3, Peter See2, Şölen Gökhan4, Mark F. Mehler5,4, Simon J. Conway6, Lai Guan Ng2, E. Richard Stanley3, Igor M. Samokhvalov7, Miriam Mérad1
1Department of Gene and Cell Medicine, and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
2Singapore Immunology Network (SIgN), 8A Biomedical Grove, IMMUNOS Building Nos. 3-4, BIOPOLIS, 138648, Singapore.
3Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
4Institute for Brain Disorders and Neural Regeneration, Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, and Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.
5Departments of Neuroscience, Psychiatry, and Behavioral Sciences, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.
6Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202, USA.
7Laboratory for Stem Cell Biology, Center for Developmental Biology (CDB), RIKEN Kobe, Kobe 6500047, Japan.

Tóm tắt

Primitive Origins for Microglia Microglia are the resident macrophages of the central nervous system and are associated with neurodegeneration and brain inflammatory diseases. Although the developmental origins of other tissue macrophage populations are well established, the origins of microglia remain controversial. Ginhoux et al. (p. 841 , published online 21 October) used in vivo lineage tracing studies to show that microglia arise early in mouse development and derive from primitive macrophages in the yolk sac. This is in contrast to other cells of the mononuclear phagocyte system, which arise later in development from a distinct progenitor population.

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American Association for the Advancement of Science (AAAS)

Tập 330 Số 6005

841-845

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