Factors That Predict Individual Vulnerability to Amphetamine Self-Administration

American Association for the Advancement of Science (AAAS) - Tập 245 Số 4925 - Trang 1511-1513 - 1989
Pier Vincenzo Piazza1, Jean-Marie. Deminière1, Michel. Le Moal1, Hervé. Simon1
1Psychobiologie des Comportements Adaptatifs, INSERM U.259, Université de Bordeaux II, 33077 Bordeaux, France.

Tóm tắt

Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.

Từ khóa


Tài liệu tham khảo

10.1126/science.7188649

BLANC, G, RESPONSE TO STRESS OF MESOCORTICO-FRONTAL DOPAMINERGIC-NEURONS IN RATS AFTER LONG-TERM ISOLATION, NATURE 284: 265 (1980).

BORNSTEIN, M.H., CONTINUITY IN MENTAL-DEVELOPMENT FROM INFANCY, CHILD DEVELOPMENT 57: 251 (1986).

DANTZER, R, STRESS IN FARM-ANIMALS - A NEED FOR REEVALUATION, JOURNAL OF ANIMAL SCIENCE 57: 6 (1983).

10.1126/science.2903550

LEMOAL, M, INCREASED SENSITIVITY TO (+)AMPHETAMINE SELF-ADMINISTERED BY RATS FOLLOWING MESO-CORTICO-LIMBIC DOPAMINE NEURON DESTRUCTION, NATURE 280: 156 (1979).

O'Brien, C. P., Behavioral Analysis of Drug Dependence: 329 (1986).

PIAZZA P.V. unpublished data.

ROBINSON, T.E., ENDURING CHANGES IN BRAIN AND BEHAVIOR PRODUCED BY CHRONIC AMPHETAMINE ADMINISTRATION - A REVIEW AND EVALUATION OF ANIMAL-MODELS OF AMPHETAMINE PSYCHOSIS, BRAIN RESEARCH REVIEWS 11: 157 (1986).

SAVAKI, H.E., RELEASE OF NEWLY SYNTHESIZED H-3 DOPAMINE IN THE STRIATUM - AN ADAPTATION OF THE PUSH-PULL CANNULA METHOD TO AWAKE RESTRAINED AND ANESTHETIZED RATS, BRAIN RESEARCH BULLETIN 16: 149 (1986).

THIERRY, A.M., SELECTIVE ACTIVATION OF MESOCORTICAL DA SYSTEM BY STRESS, NATURE 263: 242 (1976).

WEST, CHK, MILD STRESS INFLUENCES SEX-DIFFERENCES IN EXPLORATORY AND AMPHETAMINE-ENHANCED ACTIVITY IN RATS, BEHAVIOURAL BRAIN RESEARCH 30: 95 (1988).

ZETTERSTROM, T, INVIVO MEASUREMENT OF DOPAMINE AND ITS METABOLITES BY INTRACEREBRAL DIALYSIS - CHANGES AFTER D-AMPHETAMINE, JOURNAL OF NEUROCHEMISTRY 41: 1769 (1983).