Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Journal of Diabetes Research - Tập 2018 - Trang 1-17 - 2018
Anna Katrina Jógvansdóttir Gradel1,2, Trine Porsgaard2, Jens Lykkesfeldt1, Torben Seested3, S. Gram-Nielsen2, Niels Buus Kristensen4, Hanne H. F. Refsgaard2
1Department of Veterinary and Animal Sciences, Section of Experimental Animal Models, Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark
2Insulin Research, Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark
3Department of Histology and Imaging, Global Drug Discovery, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark
4Quantitative Clinical Pharmacology, Novo Nordisk A/S, Vandtårnsvej 108, 2860 Søborg, Denmark

Tóm tắt

Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the insulin absorption process and the various modifications to this process that have been utilized by the different insulin preparations available.

Từ khóa


Tài liệu tham khảo

10.1016/S0140-6736(01)05842-1

10.1056/nejm199309303291401

10.1016/S0140-6736(98)07019-6

10.1001/jama.295.14.1707

10.1111/j.1463-1326.2009.01160.x

10.1136/bmj.321.7258.405

10.1016/j.amjmed.2014.07.002

10.1016/S1262-3636(07)70160-X

10.1089/152091502320798312

10.1016/S1557-0843(08)80010-3

10.1111/dom.12087

10.1185/03007995.2016.1174107

2010, Current Opinion in Molecular Therapeutics, 12, 461

2010, The Interstitium, 1

10.1016/0014-4827(91)90351-T

10.1208/s12248-012-9367-0

10.1016/j.ejps.2011.06.005

10.1177/193229681300700128

10.1023/B:PHAM.0000036926.54824.37

2009, Metabolic processes at injection sites affecting pharmacokinetics, pharmacodynamics, and metabolism of protein and peptide therapeutics, 80

10.1111/1523-1747.ep12482470

10.1046/j.1087-0024.2000.00001.x

10.1016/0026-2862(70)90031-2

1995, Clinical Chemistry, 41, 1522, 10.1093/clinchem/41.10.1522

10.1152/ajpendo.2000.278.2.E352

10.3109/00365517409050824

10.1002/pdi.1960160711

10.1089/dia.2010.0184

10.1089/dia.2010.0204

10.1007/s13346-015-0239-x

10.1016/j.ejps.2014.05.010

10.1007/s11095-012-0739-z

10.1016/j.ejps.2008.10.018

2012, Biosimulation of peptides and proteins, 323

10.2337/dcS15-3011

10.2337/diacare.14.11.942

10.1016/s1262-3636(05)88263-1

10.1016/S0140-6736(96)06032-1

10.2337/diacare.22.9.1501

10.1007/s005920070034

10.2337/diab.46.2.265

10.1002/pdi.213

10.1007/s40261-017-0499-y

2017

2017

2017

2017

2014, Diabetologia, 57, 381S

10.2337/dc10-1892

10.1089/dia.2011.0117

10.1185/030079906X154178

10.2337/diabetes.53.6.1614

10.1007/s00125-005-1916-y

10.1016/S0140-6736(98)12459-5

10.2337/diacare.23.8.1130

10.2337/diacare.23.6.813

1971, Journal of Biological Chemistry, 246, 6786, 10.1016/S0021-9258(19)45914-0

10.2337/diacare.24.11.1984

10.1111/dom.12222

10.1111/j.1463-1326.2012.01638.x

10.1111/dom.12782

10.1007/s11095-016-2014-1

10.1111/dom.12196

2015, Diabetes, 64

10.2337/dc15-1531

10.1016/j.jcjd.2012.07.413

10.1016/s1262-3636(05)88264-3

10.1111/j.1463-1326.2012.01627.x

10.1111/j.1399-5448.2008.00443.x

10.2337/diacare.7.2.188

10.1007/BF00408474

10.2147/TCRM.S99855

10.1089/dia.2017.0094

10.2337/dc14-0006

10.1007/s40261-013-0096-7

10.1002/cpdd.221

10.1111/dom.12304

10.15277/bjd.2016.056

10.1007/BF01059088

10.2337/dc12-1319

10.1002/dmrr.205

10.1111/j.1600-0773.1969.tb03069.x

10.2337/diacare.4.3.366

2016, Diabetes Technology & Therapeutics, 18, A116

10.1080/00365518509155280

10.2337/diacare.15.11.1484

10.2337/diacare.5.2.77

10.2337/diacare.6.4.399

10.1136/bmj.280.6229.1411

10.1007/bf00283747

10.1136/bmj.284.6311.237

10.1089/dia.2013.0187

1985, Diabetes Research, 2, 187

10.2337/diacare.16.12.1592

10.7326/0003-4819-92-1-59

10.1111/j.1464-5491.1992.tb01768.x

10.2337/diacare.19.12.1437

10.1111/j.1464-5491.1990.tb01401.x

10.1152/ajpendo.00527.2011

10.1152/japplphysiol.00732.2011

10.1111/j.1463-1326.2012.01666.x

10.1007/BF00401147

10.1001/jama.1990.03440130090031

10.1007/s40261-014-0218-x

10.2337/diacare.9.6.570

1991, Acta Physiologica Scandinavica Supplementum, 143, 41

10.2337/dc10-1126

10.2337/dc16-0610

10.2337/diacare.28.8.2025

10.1111/j.1464-5491.1990.tb01494.x

10.2337/diacare.7.5.479

10.1016/j.mayocp.2016.06.010

10.1007/BF00253740

10.2337/diab.28.7.640

10.1007/BF01222209

1981, Diabetologia, 21, 161

1984, Diabetologia, 27, 238, 10.1007/BF00273813

10.1210/jcem-67-3-551

10.2337/diab.43.3.396

10.2337/diacare.13.1.74

10.1111/j.1464-5491.1989.tb01239.x

10.1111/j.1464-5491.1991.tb01509.x

10.1210/jcem-67-3-619

1991, Archivos de Investigación Médica, 22, 229

10.1177/1474651409352959

10.2337/diacare.22.10.1621

10.1161/CIRCULATIONAHA.111.027813

10.2337/diacare.16.1.1

10.1371/journal.pone.0086637

10.2337/dc10-0871

10.1016/j.diabet.2013.05.006

10.1016/j.diabres.2006.12.023

10.1177/1932296817699638

10.2337/dc13-0492

10.1111/dom.12550

10.1089/152091501300209598

2015, Bulletin of Environment, Pharmacology and Life Sciences, 4, 1

10.1007/BF00297388

10.1177/193229681000400332

2011, European Review for Medical and Pharmacological Sciences, 15, 1196

10.2165/00128071-200708010-00003

10.1055/s-2001-18991

10.2337/diacare.21.11.1910

10.1530/EJE-09-1086

10.1111/dom.12416

10.1111/j.1464-5491.1988.tb01076.x

10.1111/dom.12938

10.2337/diacare.24.2.296

10.1111/j.1463-1326.2004.00373.x

10.1007/s00125-015-3648-y

Thông tin
Thông tin xuất bản

Journal of Diabetes Research

Tập 2018

1-17

Thông tin tác giả