CÁC TRIỂN VỌNG TƯƠI SÁNG TRONG NGHIÊN CỨU MELANOMA. Báo cáo từ cuộc họp "Nghiên cứu Melanoma: một cây cầu từ Naples đến Thế giới. Napoli, ngày 5-6 tháng 12 năm 2011"

Journal of Translational Medicine - Tập 10 - Trang 1-17 - 2012
Paolo A Ascierto1,2, Antonio M Grimaldi1, Brendan Curti3, Mark B Faries4, Soldano Ferrone5, Keith Flaherty6, Bernard A Fox7, Thomas F Gajewski8, Jeffrey E Gershenwald9, Helen Gogas10, Kenneth Grossmann11, Axel Hauschild12, F Stephen Hodi13, Richard Kefford14, John M Kirkwood15, Sancy Leachmann11, Michele Maio16, Richard Marais17, Giuseppe Palmieri18, Donald L Morton4, Antoni Ribas19, David F Stroncek20, Rodney Stewart11, Ena Wang21, Nicola Mozzillo1, Franco M Marincola21
1Department of Melanoma, Sarcoma, and Head and Neck Disease, Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy
2Unit of Medical Oncology and Innovative Therapy, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione G. Pascale”, Naples, Italy
3Earle A. Chiles Research Institute, Providence Cancer Center, Portland, USA
4Department of Melanoma Research, John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, USA
5University of Pittsburgh Cancer Institute, Pittsburgh, USA
6Massachusetts General Hospital Cancer Center, Boston, USA
7Laboratory of Molecular and Tumor Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Portland Medical Center, and Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, USA
8University of Chicago, Chicago, USA
9Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
10First Department of Medicine, Athens Medical School, University of Athens, Athens, Greece
11Huntsman Cancer Institute, University of Utah, Melanoma and Cutaneous Oncology Program, Salt Lake City, USA
12Department of Dermatology, University of Kiel, Kiel, Germany
13Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA
14Westmead Institute for Cancer Research, Westmead Millennium Institute and Melanoma Institute Australia, University of Sydney, Sydney, Australia
15Division of Hematology/Oncology, Departments of Medicine, Dermatology, and Translational Science, University of Pittsburgh School of Medicine and Melanoma Program of the Pittsburgh Cancer Institute, Pittsburgh, USA
16Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy
17Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester, UK
18Unit of Cancer Genetics, Institute of Biomolecular Chemistry, National Research Council (CNR), Sassari, Italy
19UCLA Medical Center, Los Angeles, USA
20Cell Processing Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, USA
21Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and Center for Human Immunology (CHI), NIH, Bethesda, USA

Tóm tắt

Sau hơn 30 năm, đã đạt được tiến bộ đáng kể trong điều trị ung thư, đặc biệt là melanoma, với sự thành công của các phân tử mới như ipilimumab, vemurafenib và miễn dịch cụ thể hoạt động. Sau hội nghị đầu tiên vào tháng 12 năm 2010, phiên bản thứ hai của cuộc họp "Nghiên cứu Melanoma: một cây cầu từ Naples đến Thế giới", được tổ chức bởi Paolo A. Ascierto (INT, Naples, Italy), Francesco M. Marincola (NIH, Bethesda, USA) và Nicola Mozzillo (INT, Naples, Italy) đã diễn ra tại Naples vào ngày 5-6 tháng 12 năm 2011. Chúng tôi đã xác định bốn chủ đề thảo luận mới: Các phương pháp tiếp cận đổi mới trong phòng ngừa, chẩn đoán và điều trị phẫu thuật, Các con đường và mục tiêu mới trong melanoma: Cập nhật về miễn dịch liệu pháp, và Các chiến lược kết hợp. Hội nghị quốc tế này đã quy tụ hơn 30 giảng viên quốc tế và tập trung vào những tiến bộ gần đây trong sinh học phân tử melanoma, miễn dịch học và liệu pháp, đồng thời tạo ra một bầu không khí tương tác kích thích thảo luận về các phương pháp và chiến lược mới trong lĩnh vực melanoma.

Từ khóa

#melanoma #điều trị ung thư #miễn dịch liệu pháp #sinh học phân tử #chiến lược kết hợp

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