Extrapituitary Action of Gonadotropin-Releasing Hormone: Direct Inhibition Ovarian Steroidogenesis

American Association for the Advancement of Science (AAAS) - Tập 204 Số 4395 - Trang 854-855 - 1979
Aaron J. W. Hsueh1, Gregory F. Erickson1
1Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093.

Tóm tắt

Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.

Từ khóa


Tài liệu tham khảo

ARMSTRONG, D.T., ANDROGENS AUGMENT FSH-INDUCED PROGESTERONE SECRETION BY CULTURED RAT GRANULOSA-CELLS, ENDOCRINOLOGY 99: 1411 (1976).

BELCHETZ, P.E., HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE, SCIENCE 202: 631 (1978).

BERNARDO, L.A., ADRENAL LUTEINIZING-HORMONE RELEASING HORMONE RECEPTORS, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 26: 613 (1978).

CORBIN, A, ANTI-REPRODUCTIVE PHARMACOLOGY OF LH-RH AND AGONISTIC ANALOGS, INTERNATIONAL JOURNAL OF FERTILITY 23: 81 (1978).

DORRINGTON, J.H., ESTRADIOL-17-BETA BIOSYNTHESIS IN CULTURED GRANULOSA-CELLS FROM HYPOPHYSECTOMIZED IMMATURE RATS - STIMULATION BY FOLLICLE-STIMULATING HORMONE, ENDOCRINOLOGY 97: 1328 (1975).

ERICKSON, G.F., STIMULATION OF AROMATASE ACTIVITY BY FOLLICLE-STIMULATING-HORMONE IN RAT GRANULOSA-CELLS INVIVO AND INVITRO, ENDOCRINOLOGY 102: 1275 (1978).

GRANT, G, PITUITARY BINDING-SITES FOR [H-3]-LABELLED LUTEINIZING-HORMONE RELEASING FACTOR (LRF), BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 50: 771 (1973).

10.1126/science.212832

JOHNSON, E.S., DELAY OF PUBERTY AND INHIBITION OF REPRODUCTIVE PROCESSES IN RAT BY A GONADOTROPIN-RELEASING HORMONE AGONIST ANALOG, FERTILITY AND STERILITY 27: 853 (1976).

JOHNSON, E.S., ENDOCRINE-DEPENDENT RAT MAMMARY-TUMOR REGRESSION - USE OF A GONADOTROPIN-RELEASING HORMONE ANALOG, SCIENCE 194: 329 (1976).

Lin, Y. C., Program, 58th annual meeting of the Endocrine Society: 143 (1976).

LUCKY, A.W., PROGESTERONE PRODUCTION BY CULTURED PRE-ANTRAL RAT GRANULOSA-CELLS - STIMULATION BY ANDROGENS, ENDOCRINOLOGY 100: 128 (1977).

NIMROD, A, SYNERGISTIC EFFECT OF ANDROGEN ON STIMULATION OF PROGESTERONE SECRETION BY FSH IN CULTURED RAT GRANULOSA-CELLS, MOLECULAR AND CELLULAR ENDOCRINOLOGY 5: 315 (1976).

PEDROZA, E, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 79: 234 (1977).

10.1126/science.99816

SCHOMBERG, D.W., MODULATION OF PROGESTIN SECRETION IN OVARIAN CELLS BY 17BETA-HYDROXY-5ALPHA-ANDROSTAN-3-ONE(DIHYDROTESTOSTERONE) - DIRECT DEMONSTRATION IN MONOLAYER-CULTURE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 68: 77 (1976).

SPONA, J, LH-RH INTERACTION WITH PITUITARY PLASMA-MEMBRANE, FEBS LETTERS 34: 24 (1973).

STERNBERGER, L.A., QUANTITATIVE IMMUNOCYTOCHEMISTRY OF PITUITARY RECEPTORS FOR LUTEINIZING HORMONE-RELEASING HORMONE, CELL AND TISSUE RESEARCH 162: 141 (1975).

YEN, S, RECENT PROGRESS IN HORMONE RESEARCH 31: 321 (1975).