Extended-spectrum beta-lactamase production and multi-drug resistance among Enterobacteriaceae isolated in Addis Ababa, Ethiopia

Murray PR, Rosenthal KS MpM. Medical Microbiology 5th ed. Philadelphia, Pennsylvania USA; 2005.

Paterson DL. Resistance in gram-negative Bacteria: Enterobacteriaceae. Am J Med. 2006;119(6):20–8.

Paterson DL, Bonomo RA. Extended-Spectrum Beta-lactamases : a clinical update. Clin Microbiol Rev. 2005;18(4):657–86.

Pitout JDLK. Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8(3):159–66.

Bush K, Fisher JF. Epidemiological expansion , structural studies , and clinical challenges of new β -lactamases from gram-negative Bacteria. Annu Rev Microbilogy. 2011;65:455–78.

Jacoby GA, Medeiros AA. More extended-spectrum beta-lactamases. Antimicrob Agents Chemother. 1991;35(9):1697–704.

Coudron PE, Moland ES, Sanders CC. Occurrence and detection of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae at a veterans Medical center. J Clin Microbiol. 1997;35(10):2593–7.

Tzelepi E, Giakkoupi P, Sofianou D, Loukova V. Kemeroglou a, Tsakris a. Detection of extended-spectrum beta-lactamases in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes. J Clin Microbiol. 2000;38(2):542–6.

Schwaber MJ, Navon-venezia S, Schwartz D, Schwaber MJ, Navon-venezia S, Schwartz D, et al. High levels of antimicrobial Coresistance among extended-Spectrum-beta-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother. 2005;49(5):2137–9.

Chandel DS, Johnson JA, Chaudhry R, Sharma N, Shinkre N, Parida S, et al. Extended-spectrum b -lactamase-producing gram-negative bacteria causing neonatal sepsis in India in rural and urban settings. J Med Microbiol. 2011:500–7.

Paterson DL, Ko W, Gottberg AVON, Casellas JM, Mulazimoglu L, Klugman KP, et al. Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-Spectrum Beta-lactamases : implications for the clinical microbiology laboratory. Int J Antimicrob Agents. 2001;39(6):2206–12.

Walsh TR. Emerging carbapenemases : a global perspective. Int J Antimicrob Agents. 2010;36:8–14.

Giamarellou H. Treatment options for multidrug-resistant bacteria. Expert Rev Anti-Infect Ther. 2006:601–18.

Morrill HJ, Pogue JM, Kaye KS, Laplante KL. Treatment options for Carbapenem-resistant Enterobacteriaceae infections. InOpen forum Infect Dis. 2015;2(2):1–12.

Win WC, Allen SD, Janda WM, Koneman EW, Procop GW, Schreckenberger PC, Woods G editors. 6th ed. Philadelphia: Lippincott Williams and Wilkins; Colour atlas and text book of diagnostic microbiology. In: Enterobacteriaceae. 2006. p. 211–302.

CLSI. Performance standards for antimicrobial susceptibility testing. Vol. 26th ed., CLSI supplement M100S.Wayne, PA: clinical and laboratory standards institute. 2016.

Magiorakos A, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Microbiology. 2011;18(3):268–81.

EUCAST. EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and / or epidemiological importance. Eur Soc Clin Microbiol Infect Dis. 2017;Version 2:1–40.

Adler A, Katz DE, Marchaim D. The continuing plague of extended-spectrum β-lactamase–producing Enterobacteriaceae infections. Infect Dis Clin N Am. 2016;30(2):347–75.

Siraj SM, Ali S, Wondafrash B. Extended- spectrum β -lactamase production in Klebsiella pneumoniae and Escherichia coli at Jimma University specialized hospital , south-west , Ethiopia. Mol. Microbiol Res. 2015;5(1):1–9.

Mulualem Y, Kasa T, Mekonnen ZSS. Occurrence of extended spectrum beta-lactamases in multidrug resistant Escherichia coli isolated from a clinical setting in Jimma university specialized hospital, Jimma, Southwest Ethiopia. East Afr J Public Heal. 2012;9(2):58–61.

Seid J, Asrat D. Occurrence of extended spectrum β-lactamase enzymes in clinical isolates of Klebsiella species from Harar region, eastern Ethiopia. Acta Trop. 2005;95(2):143–8.

Mulisa G, Selassie LG, W T, Jarso G, Shiferew T, Zewdu A, et al. Prevalence of extended Spectrum Beta-lactamase producing Enterobacteriaceae : a cross sectional study at Adama hospital , Adama ,Ethiopia. J Emerg Infect Dis. 2016;1(1):1–6.

Abera B, Kibret M, Mulu W. Extended-spectrum beta-lactamases and antibiogram in enterobacteriaceae from clinical and drinking water sources from Bahir Dar city, Ethiopia. PLoS One. 2016;11(11):1–10.

Ouedraogo A-S, Sanou M, Kissou A, Sanou S, Solaré H, Kaboré F, et al. High prevalence •of extended-spectrum ß-lactamase producing enterobacteriaceae among clinical isolates in Burkina Faso. BMC Infect Dis. 2016;16(1):326.

Kateregga JN, Kantume R, Atuhaire C, Lubowa MN, Ndukui JG. Phenotypic expression and prevalence of ESBL-producing Enterobacteriaceae in samples collected from patients in various wards of Mulago hospital. Uganda BMC Pharmacol Toxicol. 2015;16(14):1–6.

Obeng-Nkrumah N, Twum-Danso K, Krogfelt KA, Newman MJ. High levels of extended-Spectrum Beta-lactamases in a major teaching Hospital in Ghana: the need for regular monitoring and evaluation of antibiotic resistance. Am J Trop Med Hyg. 2013;89(5):960–4.

Rao SP, Rama PS, Gurushanthappa V, Manipura R, Srinivasan K. Extended-Spectrum Beta-lactamases producing Escherichia coli and Klebsiella pneumoniae: a multi-centric study across Karnataka. J Lab Physicians. 2014;6(1):7–13.

Canton R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, et al. Prevalence and spread of extended-spectrum b-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect. 2008;14(Suppl. 1):144–53.

Medeiros AA. Evolution and Dissemination of β-lactamases accelerated by generations of β-lactam. Clin Infect Dis. 1997;24:S19–45.

Nijssen S, Florijn A, Bonten MJM, Schmitz FJ, Verhoef J, Fluit AC. Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates. Int J Antimicrob Agents. 2004;24(6):585–91.

Spanu T, Luzzaro F, Perilli M, Amicosante G, Toniolo A, Fadda G. Occurrence of extended-Spectrum b-lactamases in members of the family Enterobacteriaceae in Italy- implications for resistance to Beta-lactams and other antimicrobial drugs. Antimicrob Agents Chemother. 2002;46(1):196–202.

Fam N, Leflon-Guibout V, Fouad S, Aboul-Fadl L, Marcon E, Desouky D, et al. CTX-M-15-producing Escherichia coli clinical isolates in Cairo (Egypt). Microb Drug Resist. 2011;17(1):67–73.

Raut S, Gokhale S, Adhikari B. Prevalence of extended Spectrum Beta-lactamases among Escherichia coli and Klebsiella spp isolates in Manipal teaching hospital, Pokhara, Nepal. J Microbiol Infect Dis. 2015;5(2):69–75.

Shashwati N, Kiran T DA. Study of extended spectrum β-lactamase producing Enterobacteriaceae and antibiotic coresistance in a tertiary care teaching hospital. J Nat Sci Biol Med 2014;5(1):30.

Legese MH, Weldearegay GM, Asrat D. Extended-spectrum beta-lactamase- and carbapenemase-producing Enterobacteriaceae among ethiopian children. Infect Drug Resist. 2017;10:27–34.

Hooja S, Pal N, Karadiya R, Sharma R. Prevalence and antimicrobial susceptibility of extended Spectrum β-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae isolates in a tertiary Care Hospital in North-West India. Int J Curr Microbiol App Sci. 2016;5(5):430–9.

Dekker D, Gyau K, Kreuels B, Adu-sarkodie Y. Extended spectrum beta-lactamase producing Enterobacteriaceae causing bloodstream infections in rural Ghana, 2007–2012. Int J Med Microbiol. 2016;306(4):249–54.

Mansouri S, Samaneh A. Prevalence of multiple drug resistant clinical isolates of extended-Spectrum Beta- lactamase producing Enterobacteriaceae in Southeast Iran. Iran J Med Sci. 2010;35(2):101–8.

Kumar D, Singh AK, Ali MR, Chander Y. Antimicrobial susceptibility profile of extended Spectrum beta-lactamase (ESBL) producing Escherichia coli from various clinical samples. nfectious Dis Res Treat. 2014;7:1–8.

Alipourfard I, Nili NY. Antibiogram of extended Spectrum Beta-lactamase ( ESBL ) producing Escherichia coli and Klebsiella pneumoniae isolated from hospital samples. Bangladesh J Med Microbiol. 2010;04(01):32–6.

Kaur J, Chopra S. SHEEVANI, Mahajan G. Modified double disc synergy test to detect ESBL production in urinary isolates of Escherichia coli and Klebsiella pneumoniae. J Clin Diagnostic Res. 2013;7(2):229–33.

Yadav KK, Adhikari N, Khadka R, Pant AD, Shah B. Multidrug resistant Enterobacteriaceae and extended spectrum β-lactamase producing Escherichia coli: a cross-sectional study in National Kidney Center, Nepal. Antimicrob Resist Infect Control. 2015;4(42):1–7.

Leski TA, Taitt CR, Bangura U, Stockelman MG, Ansumana R, Iii WHC, et al. High prevalence of multidrug resistant Enterobacteriaceae isolated from outpatient urine samples but not the hospital environment in Bo , Sierra Leone. BMC Infect Dis. 2016;16:167.

Kibret M, Abera B. Antimicrobial susceptibility patterns of E. Coli from clinical sources in Northeast Ethiopia. Afr Health Sci. 2011;11(3):40–5.

Agersew A, Mulat D, Meseret A, Mucheye G. Uropathogenic bacterial isolates and their antimicrobial susceptibility patterns among HIV/AIDS patients attending Gondar University specialized hospital Gondar, Northwest Ethiopia. J microb. Res Rev. 2013;1(4):42–51.

Blomberg B, Mwakagile DSM, Urassa WK, Maselle SY, Mashurano M, Digranes A, et al. Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania. BMC Public Health. 2004;4(1):1–11.

Ibrahim ME. Increased multi-drug resistant Escherichia coli from hospitals in Khartoum state. Sudan Afr Health Sci. 2012;12(3):368–75.

Shatalov A. Prevalence and antibiotic resistance pattern of Escherichia coli and Klebsiella pneumoniae in urine tract infections at the La Paz Medical center , Malabo , Equatorial Guinea. Open J Med Microbiol. 2015;5(4):177–83.

Moges F, Mengistu GGA. Multi drug resistance in urinary pathogens at Gondar hospital. Ethiopia E Afr Med J. 2002;79(3):140–2.

Thakur S, Pokhrel NSM. Prevalence of multidrug resistant Enterobacteriaceae and extended spectrum β lactamase producing Escherichia Coli in urinary tract infection. Res J pharm biol. Chem Sci. 2013;4(2):1615.

Eshetie S, Unakal C, Gelaw A, Ayelign B, Endris M, Moges F. Multidrug resistant and carbapenemase producing Enterobacteriaceae among patients with urinary tract infection at referral hospital. Northwest Ethiopia Antimicrob Resist Infect Control. 2015;4(1):12.

Fantahun B, Bayeh A. Antimicrobial resistance of bacterial isolates from urinary tract infections at Felge Hiwot referral hospital, Ethiopia. Ethiop J Heal Heal Dev. 2009;23:236–8.