Extended spectrum beta-lactamase producing Enterobacterales faecal carriage in a medical intensive care unit: low rates of cross-transmission and infection

Renaud Prével1, Alexandre Boyer1, Fatima M’Zali2, Thibaut Cockenpot3, Agnès Lashéras4, Véronique Dubois2, Didier Gruson1
1Medical Intensive Care Unit, CHU Bordeaux, Pellegrin universitary hospital, Place Amélie Raba-Léon, F-33000, Bordeaux, France
2UMR 5234 CNRS, Bordeaux University, F-33000, Bordeaux, France
3Bacteriology laboratory, CHU Bordeaux, F-33000, Bordeaux, France
4Hygiene unit, CHU Bordeaux, F-33000, Bordeaux, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Carlet J. The World Alliance Against Antibiotic Resistance: Consensus for a Declaration. Clin Infect Dis. 2015;60:1837–41.

Woerther P-L, Burdet C, Chachaty E, Andremont A. Trends in Human Fecal Carriage of Extended-Spectrum -Lactamases in the Community: Toward the Globalization of CTX-M. Clin Microbiol Rev. 2013;26:744–58.

Karanika S, Karantanos T, Arvanitis M, Grigoras C, Mylonakis E. Fecal Colonization With Extended-spectrum Beta-lactamase–Producing Enterobacteriaceae and Risk Factors Among Healthy Individuals: A Systematic Review and Metaanalysis. Clin Infect Dis. 2016;63:310–8.

Flokas ME, Alevizakos M, Shehadeh F, Andreatos N, Mylonakis E. ESBL-producing Enterobacteriaceae Colonization in Long-Term Care Facilities (LTCFs): A Systematic Review and Meta–analysis. Int J Antimicrob Agents. 2017 [cited 2017 Oct 6]; Available from: http://linkinghub.elsevier.com/retrieve/pii/S0924857917302959 .

Nicolas-Chanoine M-H, Gruson C, Bialek-Davenet S, Bertrand X, Thomas-Jean F, Bert F, et al. 10-Fold increase (2006-11) in the rate of healthy subjects with extended-spectrum -lactamase-producing Escherichia coli faecal carriage in a Parisian check-up centre. J Antimicrob Chemother. 2013;68:562–8.

Boyer A, Couallier V, Clouzeau B, Lasheras A, M’zali F, Kann M, et al. Control of extended-spectrum β-lactamase–producing Enterobacteriaceae nosocomial acquisition in an intensive care unit: A time series regression analysis. Am J Infect Control. 2015;43:1296–301.

Zahar J-R, Lesprit P, Ruckly S, Eden A, Hikombo H, Bernard L, et al. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Int J Antimicrob Agents. 2017;49:67–73.

Arnan M, Gudiol C, Calatayud L, Liñares J, Dominguez MÁ, Batlle M, et al. Risk factors for, and clinical relevance of, faecal extended-spectrum β-lactamase producing Escherichia coli (ESBL-EC) carriage in neutropenic patients with haematological malignancies. Eur J Clin Microbiol Infect Dis. 2011;30:355–60.

Asakura T, Ikeda M, Nakamura A, Kodera S. Efficacy of empirical therapy with non-carbapenems for urinary tract infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae. Int J Infect Dis. 2014;29:91–5.

Tschudin-Sutter S, Frei R, Dangel M, Stranden A, Widmer AF. Rate of transmission of extended-spectrum beta-lactamase–producing Enterobacteriaceae without contact isolation. Clin Infect Dis. 2012;55:1505–11.

Souverein D, Euser SM, Herpers BL, Hattink C, Houtman P, Popma A, et al. No nosocomial transmission under standard hygiene precautions in short term contact patients in case of an unexpected ESBL or Q&A E. coli positive patient: a one-year prospective cohort study within three regional hospitals. Antimicrob Resist Infect Control. 2017;6. [cited 2017 Oct 6] Available from: http://aricjournal.biomedcentral.com/articles/10.1186/s13756-017-0228-6 .

Dziri R, Klibi N, Alonso CA, Said LB, Bellaaj R, Slama KB, et al. Characterization of extended-spectrum β-lactamase (ESBL)-producing Klebsiella, Enterobacter, and Citrobacter obtained in environmental samples of a Tunisian hospital. Diagn Microbiol Infect Dis. 2016;86:190–3.

Gorrie CL, Mirčeta M, Wick RR, Edwards DJ, Thomson NR, Strugnell RA, et al. Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients. Clin Infect Dis. 2017;65:208–15.

Tansarli GS, Karageorgopoulos DE, Kapaskelis A, Falagas ME. Impact of antimicrobial multidrug resistance on inpatient care cost: an evaluation of the evidence. Expert Rev Anti-Infect Ther. 2013;11:321–31.

Lindblom A, Karami N, Magnusson T, Åhrén C. Subsequent infection with extended-spectrum β-lactamase-producing Enterobacteriaceae in patients with prior infection or fecal colonization. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 2018;37:1491–7.

Bruyère R, Vigneron C, Bador J, Aho S, Toitot A, Quenot J-P, et al. Significance of Prior Digestive Colonization With Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Patients With Ventilator-Associated Pneumonia. Crit Care Med. 2015;1.

Société française d’hygiène hospitalière (SF2H). Prévention de la transmission croisée: précations complémentaires contact. 2009;XII:81.

ADARPEF, GFRUP, Leone M, Bouadma L, Bouhemad B, Brissaud O, et al. Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU. Ann Intensive Care. 2018;8. [cited 2018 Dec 7] Available from: https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-018-0444-0 .

Saladin M, Cao VTB, Lambert T, Donay J-L, Herrmann J-L, Ould-Hocine Z, et al. Diversity of CTX-M beta-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals. FEMS Microbiol Lett. 2002;209:161–8.

Saenz Y, Brinas L, Dominguez E, Ruiz J, Zarazaga M, Vila J, et al. Mechanisms of Resistance in Multiple-Antibiotic-Resistant Escherichia coli Strains of Human, Animal, and Food Origins. Antimicrob Agents Chemother. 2004;48:3996–4001.

Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33:2233.

Repessé X, Artiguenave M, Paktoris-Papine S, Espinasse F, Dinh A, Charron C, et al. Epidemiology of extended-spectrum beta-lactamase-producing Enterobacteriaceae in an intensive care unit with no single rooms. Ann Intensive Care. 2017;7. [cited 2017 Oct 6] Available from: http://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-017-0295-0

Dyakova E, Bisnauthsing KN, Querol-Rubiera A, Patel A, Ahanonu C, Tosas Auguet O, et al. Efficacy and acceptability of rectal and perineal sampling for identifying gastrointestinal colonization with extended spectrum β-lactamase Enterobacteriaceae. Clin Microbiol Infect. 2017;23:577.e1–3.

Alves M, Lemire A, Decré D, Margetis D, Bigé N, Pichereau C, et al. Extended-spectrum beta-lactamase − producing enterobacteriaceae in the intensive care unit: acquisition does not mean cross-transmission. BMC Infect Dis. 2016;16. [cited 2017 Oct 6] Available from: http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1489-z .

Bae IK, Kim J, Sun JYH, Jeong SH, Kim Y-R, Wang K-K, et al. Comparison of pulsed-field gel electrophoresis & repetitive sequence-based PCR methods for molecular epidemiological studies of Escherichia coli clinical isolates. Indian J Med Res. 2014;140:679–85.

Clark CG, Kruczkiewicz P, Guan C, McCorrister SJ, Chong P, Wylie J, et al. Evaluation of MALDI-TOF mass spectroscopy methods for determination of Escherichia coli pathotypes. J Microbiol Methods. 2013;94:180–91.

Ruppé E, Ghozlane A, Tap J, Pons N, Alvarez A-S, Maziers N, et al. Prediction of the intestinal resistome by a three-dimensional structure-based method. Nat Microbiol. 2018 [cited 2018 Dec 7]; Available from: http://www.nature.com/articles/s41564-018-0292-6 .

Woerther P-L, Angebault C, Jacquier H, Hugede H-C, Janssens A-C, Sayadi S, et al. Massive increase, spread, and exchange of extended spectrum β-lactamase-encoding genes among intestinal Enterobacteriaceae in hospitalized children with severe acute malnutrition in Niger. Clin Infect Dis Off Publ Infect Dis Soc Am. 2011;53:677–85.

Kim S, Covington A, Pamer EG. The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017;279:90–105.

Stupica D, Lusa L, Klevišar MN, Terzić S, Pirš M, Premru MM, et al. Should we consider faecal colonisation with extended-spectrum β-lactamase-producing Enterobacteriaceae in empirical therapy of community-onset sepsis? Int J Antimicrob Agents. 2017;50:564–71.

Carbonne H, Le Dorze M, Bourrel A-S, Poupet H, Poyart C, Cambau E, et al. Relation between presence of extended-spectrum β-lactamase-producing Enterobacteriaceae in systematic rectal swabs and respiratory tract specimens in ICU patients. Ann Intensive Care. 2017;7. [cited 2017 Oct 6] Available from: http://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-017-0237-x .

Jalalzaï W, Boutrot M, Guinard J, Guigon A, Bret L, Poisson D-M, et al. Cessation of screening for intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in a low-endemicity intensive care unit with universal contact precautions. Clin Microbiol Infect. 2017 [cited 2017 Dec 4]; Available from: http://linkinghub.elsevier.com/retrieve/pii/S1198743X17304329 .

Boucher A, Meybeck A, Patoz P, Valette M, Thellier D, Delannoy PY, et al. Alternatives to carbapenems in ventilator-associated pneumonia due to ESBL-producing Enterobacteriaceae. J Inf Secur. 2016;73:293–6.

Torres A, Zhong N, Pachl J, Timsit J-F, Kollef M, Chen Z, et al. Ceftazidime-avibactam versus meropenem in nosocomial pneumonia, including ventilator-associated pneumonia (REPROVE): a randomised, double-blind, phase 3 non-inferiority trial. Lancet Infect Dis. 2018;18:285–95.

Wagenlehner FM, Umeh O, Steenbergen J, Yuan G, Darouiche RO. Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet Lond Engl. 2015;385:1949–56.

Timsit J-F, Pilmis B, Zahar J-R. How Should We Treat Hospital-Acquired and Ventilator-Associated Pneumonia Caused by Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae? Semin Respir Crit Care Med. 2017;38:287–300.

Harris PNA, Tambyah PA, Lye DC, Mo Y, Lee TH, Yilmaz M, et al. Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial. JAMA. 2018;320:984–94.

Prevel R, Berdaï D, Boyer A. Antibiotics for Ceftriaxone-Resistant Gram-Negative Bacterial Bloodstream Infections. JAMA. 2019;321:613.

Razazi K, Mekontso Dessap A, Carteaux G, Jansen C, Decousser J-W, de Prost N, et al. Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae. Ann Intensive Care. 2017;7:61.

Gurieva T, Dautzenberg MJD, Gniadkowski M, Derde LPG, Bonten MJM, Bootsma MCJ. The Transmissibility of Antibiotic-Resistant Enterobacteriaceae in Intensive Care Units. Clin Infect Dis. 2018;66:489–93.