Expression of the short-chain fatty acid receptor, GPR43, in the human colon

Andoh A, Tsujikawa T, Fujiyama Y (2003) Role of dietary fiber and short-chain fatty acids in the colon. Curr Pharm Des 9:347–358

Binder HJ, Mehta P (1989) Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 96:989–996

Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ (2003) The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278:11312–11319

Cohen P, Zhao C, Cai X, Montez JM, Rohani SC, Feinstein P, Mombaerts P, Friedman JM (2001) Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108:1113–1121

Cuche G, Malbert CH (1999) Short-chain fatty acids present in the ileum inhibit fasting gastrointestinal motility in conscious pigs. Neurogastroenterol Motil 11:219–225

Cuche G, Cuber JC, Malbert CH (2000) Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway. Am J Physiol Gastrointest Liver Physiol 279:G925–G930

Cummings JH, Rombeau JL, Sakata T (1995) Physiological and clinical aspects of short-chain fatty acids. Cambridge University Press, Cambridge, UK

D’Argenio G, Cosenza V, Delle Cave M, Iovino P, Delle Valle N, Lombardi G, Mazzacca G (1996) Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model. Gastroenterology 110:1727–1734

Dass NB, John AK, Bassil AK, Crumbley CW, Shehee WR, Maurio FP, Moore GB, Taylor CM, Sanger GJ (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil 19:66–74

Diener M, Vujicic Z, Scharrer E (1996) Neuronally mediated anion secretion induced by short-chain fatty acids in the rat distal small intestine. Acta Physiol Scand 157:33–40

Galvez J, Rodriguez Cabezas ME, Zarzuelo A (2005) Effects of dietary fiber on inflammatory bowel disease. Mol Nutr Food Res 49:601–608

Hubel KA, Russ L (1993) Mechanisms of the secretory response to luminal propionate in rat descending colon in vitro. J Auton Nerv Syst 43:219–229

Karaki SI, Kuwahara A (2004) Regulation of intestinal secretion involved in the interaction between neurotransmitters and prostaglandin E2. Neurogastroenterol Motil 16 Suppl 1:96–99

Karaki S, Mitsui R, Hayashi H, Kato I, Sugiya H, Iwanaga T, Furness JB, Kuwahara A (2006) Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 324:353–360

Kles KA, Chang EB (2006) Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure. Gastroenterology 130:S100–S105

Kripke SA, Fox AD, Berman JM, Settle RG, Rombeau JL (1989) Stimulation of intestinal mucosal growth with intracolonic infusion of short-chain fatty acids. J Parenter Enteral Nutr 13:109–116

Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278:25481–25489

Lutz T, Scharrer E (1991) Effect of short-chain fatty acids on calcium absorption by the rat colon. Exp Physiol 76:615–618

Mitsui R, Ono S, Karaki S, Kuwahara A (2005a) Neural and non-neural mediation of propionate-induced contractile responses in the rat distal colon. Neurogastroenterol Motil 17:585–594

Mitsui R, Ono S, Karaki S, Kuwahara A (2005b) Propionate modulates spontaneous contractions via enteric nerves and prostaglandin release in the rat distal colon. Jpn J Physiol 55:331–338

Mitsui R, Karaki SI, Kubo Y, Sugiura Y, Kuwahara A (2006) Fibre-free diet leads to impairment of neuronally mediated muscle contractile response in rat distal colon. Neurogastroenterol Motil 18:1093–1101

Mortensen FV, Hielsen H (1995) In vivo and in vitro effects of short-chain fatty acids on intestinal blood circulation. In: Cummings JH, Rombeau JL, Sakata T (eds) Physiological and clinical aspects of short-chain fatty acids. Cambridge University Press, Cambridge, UK Cambridge, pp 391–400

Ono S, Karaki S, Kuwahara A (2004) Short-chain fatty acids decrease the frequency of spontaneous contractions of longitudinal muscle via enteric nerves in rat distal colon. Jpn J Physiol 54:483–493

Ropert A, Cherbut C, Roze C, Le Quellec A, Holst JJ, Fu Cheng X, Bruley des Varannes S, Galmiche JP (1996) Colonic fermentation and proximal gastric tone in humans. Gastroenterology 111:289–296

Sakata T (1987) Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors. Br J Nutr 58:95–103

Scheppach W, Bartram P, Richter A, Richter F, Liepold H, Dusel G, Hofstetter G, Ruthlein J, Kasper H (1992) Effect of short-chain fatty acids on the human colonic mucosa in vitro. J Parenter Enteral Nutr 16:43–48

Tedelind S, Westberg F, Kjerrulf M, Vidal A (2007) Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease. World J Gastroenterol 13:2826–2832

Topping DL, Clifton PM (2001) Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 81:1031–1064

Vidyasagar S, Ramakrishna BS (2002) Effects of butyrate on active sodium and chloride transport in rat and rabbit distal colon. J Physiol 539:163–173

Wren AM, Bloom SR (2007) Gut hormones and appetite control. Gastroenterology 132:2116–2130

Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M (2004) Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA 101:1045–1050

Yajima T (1985) Contractile effect of short-chain fatty acids on the isolated colon of the rat. J Physiol 368:667–678

Yajima T (1988) Luminal propionate-induced secretory response in the rat distal colon in vitro. J Physiol 403:559–575

Yonezawa T, Kobayashi Y, Obara Y (2007) Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line. Cell Signal 19:185–193