Expression of homeobox genes <i>Msx‐1 (Hox‐7)</i> and <i>Msx‐2 (Hox‐8)</i> during cardiac development in the chick

Developmental Dynamics - Tập 197 Số 3 - Trang 203-216 - 1993
P S Chan-Thomas1,2,3,4, Robert P. Thompson1,2,3,4, Benoît Robert1,2,3,4, Magdi H. Yacoub1,2,3,4, Paul J.R. Barton1,2,3,4
1Department of Cardiothoracic Surgery, National Heart and Lung In-stitute, Dovehouse Street, London SW3 6LY, United Kingdom.
2Department of Cardiothoracic Surgery, National Heart and Lung Institute, London SW3 6LY, United Kingdom
3Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina (R.P.T.);
4Dkpartement de Biologie Molkculaire, Institut Pasteur, 75724 Paris, Cedex 15, France

Tóm tắt

AbstractThe vertebrate homeobox genes Msx‐1 and Msx‐2 are related to the Drosophila mshgene and are expressed in a variety of tissues during embryogenesis. We have examined their expression by in situ hybridisation during critical stages of cardiac development in the chick from stages 15 + to 37. Msx‐1 expression is apparent in a number of non‐myocardial cell populations, including cells undergoing an epithelial to mesenchymal transformation in the atrioventricular and the outflow tract regions that play an integral role in heart septation and valve formation. Msx.2 expression is restricted to a distinct subpopulation of myocardial cells that, in later stages, coincides morphologically with the cardiac conduction system. The timing of Msx‐2 expression suggests that it plays a role in conduction system tissue formation and that it identifies precursor cells of this specialised myocardium. The pattern of Msx‐2 expression is discussed with reference to current models of conduction tissue development. © 1993 Wiley‐Liss, Inc.

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Tài liệu tham khảo

Akhurst R. J., 1990, TGF beta in murine morphogenetic processes: The early embryo and cardiogenesis, Development, 108, 645, 10.1242/dev.108.4.645

10.1038/350473a0

Coelho C. N. D., 1991, Altered expression of the chicken homeobox containing genes GHox‐7 and GHox‐8 in the limb buds of limbless mutant chick embryos, Development, 113, 1487, 10.1242/dev.113.4.1487

10.1038/352429a0

Dollé P., 1990, Retinoic acid receptors and cellular retinoid binding proteins I. A systematic study of their differential pattern of transcription during mouse organogenesis, Development, 110, 1133, 10.1242/dev.110.4.1133

10.1016/0896-6273(92)90217-2

10.1007/BF00338048

10.1002/bies.950131004

10.1242/dev.104.Supplement.169

Gehring W. J., 1987, Molecular Approaches to Developmental Biology, 115

10.1002/jmor.1050880104

10.1016/0012-1606(77)90220-2

Hill R. E., 1989, A new family of mouse homeobox‐containing genes: Molecular structure, chromosomal location, and development expression of Hox7.1. Genes, Dev., 3, 26

10.1002/aja.1001840204

Icardo J. M., 1992, The Heart and Cardiovascular System, 1563

Ikeda T., 1990, Developmental Cardiology: Morphogenesis and Function, 237

10.1242/dev.111.2.531

10.1016/0012-1606(85)90414-2

10.1016/0012-1606(87)90237-5

10.1002/bies.950140408

10.1002/ar.1092170407

10.1002/mrd.1080320402

Lyons K. M., 1990, Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein 2 (BMP‐2A), Development, 109, 833, 10.1242/dev.109.4.833

MacKenzie A., 1991, The homeobox gene Hox‐7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro, Development, 111, 269, 10.1242/dev.111.2.269

MacKenzie A., 1991, Hox 7.1 expression during murine craniofacial development, Development, 113, 601, 10.1242/dev.113.2.601

MacKenzie A., 1992, Expression patterns of the homeobox gene, Hox‐8, in the mouse embryo suggest a role in specifying tooth initiation and shape, Development, 115, 403, 10.1242/dev.115.2.403

Markwald R. R., 1985, Cardiac Morphogenesis, 60

Millan F. A., 1991, Embryonic gene expression patterns of TGF β1, β2 and β3 suggest different developmental functions in vivo, Development, 111, 131, 10.1242/dev.111.1.131

10.1016/0012-1606(87)90206-5

Monaghan A. P., 1991, The Msh‐like homeobox genes define domains in the developing vertebrate eye, Development, 112, 1053, 10.1242/dev.112.4.1053

Morse D. E., 1981, Perspectives in Cardiovascular Research, 139

Noden D. M., 1991, Origins and patterning of avian outflow tract, Development, 111, 867, 10.1242/dev.111.4.867

10.1083/jcb.115.4.1091

10.1242/dev.114.1.233

10.1161/01.RES.60.1.27

10.1016/0012-1606(89)90111-5

10.1073/pnas.88.4.1516

Robb J. S., 1968, Comparative Basic Cardiology, 348

10.1002/j.1460-2075.1989.tb03352.x

10.1101/gad.5.12b.2363

10.1016/0012-1606(83)90010-6

10.1007/BF00303148

Sassoon D. A., 1988, Transcripts of α‐cardiac and α‐skeletal actins are markers for myogenesis in the mouse embryo, Development, 104, 155, 10.1242/dev.104.1.155

Schmid P., 1991, Differential expression of TGF β1, β2 and β3 genes during mouse embryogenesis, Development, 111, 117, 10.1242/dev.111.1.117

10.1016/0092-8674(92)90588-4

10.1038/360477a0

10.1016/0012-1606(69)90052-9

Su M.‐W., 1991, Progressively restricted expression of a new homeobox‐containing gene during Xenopus laevis embryogenesis, Development, 111, 1179, 10.1242/dev.111.4.1179

10.1016/0012-1606(91)90345-4

10.1073/pnas.87.19.7482

Takahashi Y., 1991, Epitheliomesenchymal interactions are critical for Quox 7 expression and membrane bone differentiation in the neural crest derived mandibular mesenchyme, EMBO J., 10, 2387, 10.1002/j.1460-2075.1991.tb07777.x

Thompson R. P., 1990, Developmental Cardiology: Morphogenesis and Function, 219

Vassall‐Adams P. R., 1982, The development of the atrioventricular bundle and its branches in the avian heart, J. Anat., 134, 169

Wenink A. C. G., 1976, Development of the human cardiac conducting system, J. Anat., 121, 617

10.1002/ar.1092320111

Wilkinson D. G., 1987, A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin, Development, 99, 493, 10.1242/dev.99.4.493

10.1038/353443a0

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Developmental Dynamics

Tập 197 Số 3

203-216

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