Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications

Cancer Science - Tập 102 Số 4 - Trang 903-908 - 2011
Nur Rahadiani1, Jun‐ichiro Ikeda1, Suhana Mamat2,1, Shinya Matsuzaki3, Yutaka Ueda3, Reina Umehara1, Tian Tian1, Yi Wang1, Takayuki Enomoto3, Tadashi Kimura3, Katsuyuki Aozasa1, Eiichi Morii1
1Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan
2Department of Basic Health Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan, Pahang, Malaysia
3Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan

Tóm tắt

Aldehyde dehydrogenase 1 (ALDH1) is expressed in stem/progenitor cells, including cancer‐initiating cells (CIC) of various organs. In the present study, ALDH1 expression was immunohistochemically examined in uterine endometrioid adenocarcinoma. The ALDH1 was expressed in a small portion of tumor cells, and these ALDH1‐expressing cells were less mature than ALDH1‐non‐expressing cells. The ALDH1‐expressing (ALDH1‐hi) cells were more tumorigenic, resistant to anti‐cancer agents and more invasive than ALDH1‐lo cells. Culture of the sorted ALDH1‐hi cells yielded both ALDH1‐hi and ALDH1‐lo cells, whereas ALDH1‐lo cells yielded ALDH‐lo cells alone. Clinically, a high‐level of ALDH1 expression in tumor cells was correlated with T category, lymphatic invasion, recurrence and prognosis of patients. Patients with high ALDH1 expression showed poorer prognoses than those with low expression (P = 0.015 for disease‐free survival [DFS] and P = 0.010 for overall survival [OS]), and high ALDH1 expression was an independent factor for poor prognosis. Aldehyde dehydrogenase 1 is a candidate for CIC marker for uterine endometrioid adenocarcinoma. (Cancer Sci 2011; 102: 903–908)

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Cancer Science

Tập 102 Số 4

903-908

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