Expression of Concern: The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment

Addiction Biology - Tập 24 Số 4 - Trang 754-764 - 2019
Amir Ghaderi1, Hamid Reza Banafshe1,2, Naghmeh Mirhosseini3, Maryam Motmaen4, Fatemeh Mehrzad4, Fereshteh Bahmani5, Esmat Aghadavod5, Mohammad Alì Mansournia6, Rüssel J. Reiter7, Mohammad‐Amin Karimi8, Zatollah Asemi5
1Department of Addiction Studies, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
2Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
3Pure North S’Energy Foundation, Calgary, AB, Canada
4Department of Psychiatry, School of Medicine, Kashan University of Medical Science, Kashan, Iran
5Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
6Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
7Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX USA
8Department of Educational Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

Tóm tắt

AbstractThis investigation was designed to determine the effect of melatonin supplementation on mental health parameters, metabolic and genetic profiles in patients under methadone maintenance treatment (MMT). This randomized, double‐blind, placebo‐controlled, clinical trial was conducted among 54 patients under MMT. Participants were randomly allocated to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 26) or placebo (n = 28) once a day, 1 hour before bedtime for 12 weeks. Melatonin supplementation significantly decreased Pittsburgh Sleep Quality Index (β −4.08; 95 percent CI, −5.51, −2.65; P < 0.001), Beck Depression Inventory index (β −5.46; 95% CI, −8.92, −2.00; P = 0.003) and Beck Anxiety Inventory index (β −3.87; 95% CI, −5.96, −1.77; P = 0.001) and significantly increased International Index of Erectile Functions (β 5.59; 95% CI, 1.76, 9.42; P = 0.005) compared with the placebo. Subjects who received melatonin supplements had significantly lower serum insulin levels (β −2.53; 95% CI, −4.48, −0.59; P = 0.01), homeostasis model of assessment‐insulin resistance (β −0.56; 95% CI, −1.03, −0.09; P = 0.01) and higher quantitative insulin sensitivity check index (β 0.01; 95% CI, 0.004, 0.02; P = 0.009) and HDL‐cholesterol levels (β 3.71; 95% CI, 1.77, 5.64; P = 0.002) compared to placebo. Additionally, melatonin intake resulted in a significant reduction in serum high sensitivity C‐reactive protein (β −0.15; 95% CI, −0.27, −0.02; P = 0.02), malondialdehyde (β −0.31; 95% CI, −0.57, −0.05; P = 0.02) and protein carbonyl (β −0.06; 95% CI, −0.09, −0.04; P < 0.001). This trial indicated that taking melatonin supplements for 12 weeks by patients under MMT had beneficial effects on their mental health metabolic profiles.

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Addiction Biology

Tập 24 Số 4

754-764

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