Tập thể dục thúc đẩy sự biểu hiện của yếu tố thần kinh đạm nguồn gốc từ não (BDNF) thông qua tác động của ketone body β-hydroxybutyrate
Tóm tắt
Tập thể dục gây ra những phản ứng có lợi cho não bộ, đi kèm với sự gia tăng của BDNF, một yếu tố dinh dưỡng liên quan đến việc cải thiện nhận thức và giảm bớt trầm cảm, lo âu. Tuy nhiên, cơ chế chính xác mà tập thể dục gây ra sự kích thích biểu hiện gen Bdnf trong não vẫn chưa được hiểu rõ. Mặc dù các liều HDAC ức chế dược lý có tác dụng tích cực đến quá trình phiên mã gen Bdnf, nhưng những chất ức chế này lại là các phân tử nhỏ không hiện diện trong cơ thể. Ở đây, chúng tôi báo cáo rằng một phân tử nội sinh được giải phóng sau khi tập thể dục có khả năng kích thích các nhà quảng bá chính của gen Bdnf ở loài chuột nhà (Mus musculus). Chất chuyển hóa β-hydroxybutyrate, tăng lên sau khi tập thể dục kéo dài, kích thích hoạt động của các nhà quảng bá Bdnf, đặc biệt là nhà quảng bá I, mà hoạt động phụ thuộc vào mức độ. Chúng tôi đã phát hiện ra rằng tác động của β-hydroxybutyrate chủ yếu tác động vào HDAC2 và HDAC3, những chất ức chế này tác động vào các nhà quảng bá Bdnf chọn lọc. Hơn nữa, các tác động lên sự biểu hiện Bdnf ở hồi hải mã được quan sát thấy sau khi áp dụng trực tiếp β-hydroxybutyrate vào não thất. Các phép đo điện sinh lý cho thấy rằng β-hydroxybutyrate gây ra sự gia tăng trong việc giải phóng chất truyền cho thần kinh, mà phụ thuộc vào thụ thể TrkB. Những kết quả này tiết lộ một cơ chế nội sinh để giải thích cách mà tập thể dục dẫn đến sự kích thích BDNF.
Từ khóa
#tập thể dục #BDNF #β-hydroxybutyrate #gen Bdnf #hồi hải mãTài liệu tham khảo
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