Exercise and vascular function: how much is too much?

Canadian Journal of Physiology and Pharmacology - Tập 92 Số 7 - Trang 551-557 - 2014
Matthew J. Durand1, David D. Gutterman1
1Department of Medicine, Cardiology Division, and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Tóm tắt

Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals at risk for cardiovascular disease, less is known about how exercise, especially intense exercise, affects vascular function in healthy individuals. This review highlights examples of how vascular function can paradoxically be impaired in otherwise healthy individuals by extreme levels of exercise, with a focus on the causative role that reactive oxygen species play in this impairment.

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Thông tin xuất bản

Canadian Journal of Physiology and Pharmacology

Tập 92 Số 7

551-557

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