Evolution of the immune system in humans from infancy to old age

Proceedings of the Royal Society B: Biological Sciences - Tập 282 Số 1821 - Trang 20143085 - 2015
James H. Shelhamer1, Georg A. Holländer2, Andrew J. McMichael3
1Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
2Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
3Nuffield Department of Medicine Research Building, University of Oxford, Old Road Campus, Oxford OX3 7FZ, UK

Tóm tắt

This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy.

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Proceedings of the Royal Society B: Biological Sciences

Tập 282 Số 1821

20143085

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