Evidences for tangential migrations in Xenopus telencephalon: Developmental patterns and cell tracking experiments

Developmental Neurobiology - Tập 68 Số 4 - Trang 504-520 - 2008
Nerea Moreno1, Agustı́n González2,1,3, Sylvie Rétaux2,3
1Departamento de Biologia Celular, Facultad de Biologia (Av. Jose Antonio Novais, 2, 28040 Madrid - Spain)
2DEPSN - Développement, évolution et plasticité du système nerveux (D.E.P.S.N, I.N.A.F. 1 av. de la Terrasse - Bât 32/33 91198 GIF SUR YVETTE CEDEX - France)
3INAF - Institut de Neurobiologie Alfred Fessard (Bât. 32/33 1 Avenue de la terrasse 91198 GIF SUR YVETTE CEDEX - France)

Tóm tắt

AbstractExtensive tangential cell migrations have been described in the developing mammalian, avian, and reptilian forebrain, and they are viewed as a powerful developmental mechanism to increase neuronal complexity in a given brain structure. Here, we report for the first time anatomical and cell tracking evidence for the presence of important migratory processes in the developing forebrain of the anamniote Xenopus laevis. Combining developmental gene expression patterns (Pax6, Nkx2.1, Isl1, Lhx5, Lhx9, and Dll3), neurotransmitter identity (GABA, NOS, ChAT), and connectivity information, several types of putative migratory cell populations and migration routes originating in the ventral pallium and the subpallium are proposed. By means of in vivo cell tracking experiments, pallio‐subpallial and subpallio‐pallial migrating neurons are visualized. Among them, populations of Nkx2.1+ striatal interneurons and pallial GABAergic interneurons, which also express the migratory marker doublecortin, are identified. Finally, we find that these tangentially migrating pallial interneurons travel through an “isl1‐free channel” that may guide their course through the subpallium. Our findings strongly suggest that the developing Xenopus telencephalon shares many similarities with amniotes in terms of neuronal specification and migrations. However, some differences are discussed, particularly with regard to the evolution of the pallium. © 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008

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Developmental Neurobiology

Tập 68 Số 4

504-520

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