Evidence for a specific role of the anterior hippocampal region in successful associative encoding

Hippocampus - Tập 17 Số 11 - Trang 1071-1080 - 2007
Elizabeth F. Chua1, Daniel L. Schacter, Erin Rand‐Giovannetti, Reisa A. Sperling
1Department of Neurology; Brigham and Women's Hospital; Boston, Massachusetts USA.

Tóm tắt

AbstractIt has been well established that the hippocampal formation plays a critical role in the formation of memories. However, functional specialization within the hippocampus remains controversial. Using functional magnetic resonance imaging (fMRI) during a face‐name associative encoding task, followed by a postscan recognition test for face memory and face‐name pair memory, we investigated the roles of anterior and posterior hippocampal regions in successful encoding of associations and items. Whole‐brain and region of interest (ROI) analyses revealed that the anterior hippocampal formation showed increased activation for subsequently remembered face‐name associations compared with pairs that were forgotten. In contrast, the posterior hippocampal formation showed activation above baseline during attempted encoding of face‐name pairs, but no evidence of differential activation based on subsequent memory. Furthermore, exploratory whole‐brain analyses revealed that a parahippocampal region, most likely corresponding to perirhinal cortex, showed subsequent memory effects for faces. These data provide evidence for functional specialization within the hippocampal formation based on the associative nature of the stimuli and subsequent memory. © 2007 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1017/S0140525X99002034

10.1016/0306-4522(89)90424-7

10.1126/science.281.5380.1185

10.1002/hipo.450050503

10.1162/0898929041920568

10.1002/(SICI)1097-0193(1999)8:2/3<109::AID-HBM7>3.0.CO;2-W

10.1016/j.conb.2006.10.012

10.1152/jn.2002.88.2.982

10.1002/(SICI)1096-9861(19980817)398:1<25::AID-CNE3>3.0.CO;2-B

10.1523/JNEUROSCI.3420-04.2005

10.3758/CABN.3.3.186

10.1002/hipo.10182

10.1080/02724990444000113

10.1212/WNL.58.5.750

10.1016/j.neuroimage.2003.09.050

10.1002/hipo.20014

10.1002/hipo.10077

10.1002/hipo.20098

10.1006/jmla.1996.0010

10.1016/j.neuroscience.2005.08.082

10.1038/nn967

10.1002/hipo.10049

10.1523/JNEUROSCI.2540-04.2005

10.1016/j.neuropsychologia.2003.07.006

10.1002/(SICI)1098-1063(1999)9:1<7::AID-HIPO2>3.0.CO;2-K

10.1162/jocn.1997.9.5.648

10.1038/86115

10.1002/hbm.1047

10.1136/jnnp.74.1.44

10.1016/S1053-8119(03)00391-4

10.1146/annurev.neuro.27.070203.144130

10.1523/JNEUROSCI.23-17-06748.2003

10.1073/pnas.221462998

10.1002/hipo.10085

10.1101/lm.51802

10.1016/j.neuropsychologia.2003.10.003

10.1126/science.281.5380.1188

10.1093/cercor/bhg125

10.1111/j.1749-6632.2000.tb06716.x

10.1006/jmla.2002.2864

10.1038/nn961

10.1006/nimg.2000.0561

10.1002/ar.1061

10.1126/science.1077775

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Hippocampus

Tập 17 Số 11

1071-1080

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