Evidence‐based veterinary dermatology: a systematic review of interventions for<i>Malassezia</i>dermatitis in dogs

Veterinary Dermatology - Tập 20 Số 1 - Trang 1-12 - 2009
Amélie Negre1, Emmanuel Bensignor1, Jacques Guillot2,3
1Clinique Vétérinaire
2Unité mixte de recherche biologie moléculaire et immunologie parasitaires et fongiques
3École nationale vétérinaire - Alfort

Tóm tắt

AbstractThe aim of this systematic review was to evaluate the efficacy of antifungal treatments forMalasseziadermatitis in dogs and, when possible, to propose recommendation for or against their use.Electronic searches were carried out using PubMed MEDLINE®, CABDirect and CONSULTANT database. The volumes ofAdvances in Veterinary Dermatology, the proceedings of ESVD/ECVD and AAVD/ACVD congresses were hand‐searched for studies relevant to this review. All articles and book chapters discussing treatment ofMalasseziadermatitis were scanned for additional citations. Lastly, a request was sent to the Vetderm Listserv to share recent clinical trials. The analysis evaluated study design, methodology quality, subject enrolment quality, type of interventions and outcome measures.The searches identified 35 articles, and 14 trials that fulfilled the following selection criteria: (i)in vivoclinical trials, (ii) dogs showing clinical lesions ofMalasseziadermatitis and (iii) enrolment of at least five dogs. Among these, only eight studies fulfilled the following additional criterion: (iv) prospectivein vivoclinical trials reporting clinical and mycological outcome measures. A total number of 14 different treatment protocols included four blinded, randomized and controlled trials (quality of evidence grade A), four controlled studies lacking blinding and/or randomization (grade B), five open uncontrolled trials (grade C) and one descriptive study (grade D).This systematic review allowed us to recommend, with good evidence, the use of only one topical treatment ofMalasseziadermatitis (2% miconazole nitrate +2% chlorhexidine, twice a week for 3 weeks) and with fair evidence the use of two systemic treatments with azole derivatives (ketoconazole, 10 mg kg−1 day−1and itraconazole, 5 mg kg−1 day−1for 3 weeks).

Từ khóa


Tài liệu tham khảo

Scott DW, 2001, Muller and Kirk's Small Animal Dermatology, 363

10.1016/0034-5288(95)90066-7

10.1111/j.1365-280X.1999.00237.x

Bond R., 2002, Advances in Veterinary Dermatology, 69

Dufait R., 1983, Pityrosporum canis as the cause of canine chronic dermatitis, Veterinary Medicine and Small Animal Clinician, 78, 1055

10.1056/NEJM199803123381102

10.3201/eid1101.040882

10.1046/j.1365-3164.1997.d01-15.x

10.1111/j.1748-5827.1996.tb02353.x

Plant JD, 1992, Factors associated with and prevalence of high Malassezia pachydermatis numbers on dog skin, Journal of the American Veterinary Medical Association, 201, 879, 10.2460/javma.1992.201.06.879

10.1046/j.1365-3164.1997.d01-4.x

Mason KV, 1993, Current Veterinary Dermatology, 44

10.1016/S0195-5616(99)50128-9

Muse R., 2000, Current Veterinary Therapy XIII. Small Animal Practice, 574

Mason KV, 1991, Dermatitis associated with Malassezia pachydermatis in 11 dogs, Journal of the American Animal Hospital Association, 27, 13

White SD, 1998, Advances in Veterinary Dermatology, 291

Matousek JL, 2002, Malassezia dermatitis, Compendium on Continuing Education for the Practicing Veterinarian, 24, 224

Bond R., 1997, Malassezia pachydermatis and canine skin disease, Waltham Focus, 7, 27

Mason KV, 1993, Advances in Veterinary Dermatology, 399

10.1111/j.1365-3164.2004.00344.x

10.1111/j.1365-3164.2005.00460.x

10.1046/j.1365-3164.2003.00335.x

Bensignor E., 2001, Comparaison de deux posologies de kétoconazole pour le traitement de la dermatite àMalassezia chez le chien, Annales de Médecine Vétérinaire, 145, 311

10.1111/j.1365-3164.2005.00455.x

Sai JP, 2006, Therapeutic studies on seborrheic dermatitis in dogs associated with Malassezia pachydermatis, Indian Veterinary Journal, 83, 162

Carlotti DN, 1996, Dermatite àMalassezia chez le chien: étude bibliographique et rétrospective de 12 cas généralisés traités par des dérivés azolés, Pratique Médicale et Chirurgicale Des Animaux de Compagnie, 31, 297

Bensignor E., 2006, Oral itraconazole as a pulse therapy for the treatment of canine Malassezia dermatitis: a randomized, blinded, comparative trial, Pratique Médicale et Chirurgicale de L’animal de Compagnie, 41, 69

10.2460/javma.2002.220.1807

Ashok K, 2002, Treatment of dermatitis in dogs associated with Malassezia pachydermatis, Indian Veterinary Journal, 79, 730

Ayoung J, 2005, Efficacy of itraconazole in 18 cases of Malassezia dermatitis in dogs, Journal of Veterinary Clinics, 22, 90

10.1111/j.1748-5827.1995.tb02840.x

MasonKV AtwellRB.Clinical efficacy studies on sebolyse shampoo.Proceedings of the 10th Annual Congress of the American Academy and American College of Veterinary Dermatology Charleston 1994:56–7.

MasonKV AtwellRB.Clinical efficacy trials on a chlorhexidine/ miconazole shampoo for the treatment of seborrhoeic dermatitis associated with an overgrowth ofMalassezia pachydermatitisand coccoid bacteria.Proceedings of the 12th Annual Congress of the European College and the European Society of Veterinary Dermatology Barcelona 1995:222.

JasminP SchroederH BriggsM LastR SanquerA.Assessment of the efficacy of a 3% chlorhexidine shampoo in the control of elevated cutaneousMalasseziapopulations and associated clinical signs (Malasseziadermatitis) in dogs.Proceedings of the 19th Annual Congress of the ESVD ECVD Tenerife 2003:170.

Rème C, 2003, Efficacy of combined topical therapy with keratoregulating shampoo and lotion in the management of keratoseborroeic disorders associated with Malassezia proliferation in dogs, Veterinary Dermatology, 14, 264

CarlottiDN RèmeCA.Efficacy of a soothing astringent topical spray for the management ofMalasseziapododermatitis in dogs: a preliminary open‐label clinical trial.Proceedings of the 47th Annual British Small Animal Veterinary Association Congress Birmingham 2004:592.

10.1136/bmj.323.7303.42

10.1111/j.1365-3164.1997.tb00257.x

10.1016/S0190-9622(08)81495-8

10.1016/S0190-9622(94)70112-1

10.1016/0195-6701(93)90109-D

Dufait R., 1981, Over de werking van enkele Imidazole verbindingen op Pityrosporum canis, Vlaams Diergeneeskundig Tijdschrift, 50, 99

Gabal MA, 1986, Antifungal activity of ketoconazole with emphasis of zoophilic fungal pathogens, American Journal of Veterinary Research, 47, 1229

Harvey RG, 2000, Manuel de dermatologie canine et féline, Paris Masson, 34

10.1111/j.1365-3164.2008.00675.x

10.1046/j.1365-2133.2000.03294.x

10.1128/AAC.44.2.467-469.2000

10.1128/JCM.42.8.3589-3593.2004

10.1111/j.1439-0442.2007.00996.x

10.1128/AAC.47.7.2342-2344.2003

10.1111/j.1365-3164.2007.00583.x

Thông tin
Thông tin xuất bản

Veterinary Dermatology

Tập 20 Số 1

1-12

Thông tin tác giả