Events at the Host-Microbial Interface of the Gastrointestinal Tract V. Paneth cell α-defensins in intestinal host defense

American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 289 Số 2 - Trang G173-G176 - 2005
Charles Bevins1
1Dept. of Medical Microbiology and Immunology, University of California School of Medicine, One Shields Ave., Tupper Hall Rm. 3146, Davis, CA 95616, USA.

Tóm tắt

Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including α-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce α-defensins. The α-defensins are cysteine-rich cationic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell α-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell α-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.

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American Journal of Physiology - Gastrointestinal and Liver Physiology

Tập 289 Số 2

G173-G176

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