Events at the Host-Microbial Interface of the Gastrointestinal Tract II. Role of the intestinal epithelium in pathogen-induced inflammation

American Journal of Physiology - Gastrointestinal and Liver Physiology - Tập 288 Số 5 - Trang G854-G859 - 2005
Karen L. Mumy1, Beth A. McCormick
1Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown MA 02129, USA

Tóm tắt

An immense number of bacteria reside within the intestinal lumen. The task of appropriately identifying and responding to microbial threats lies primarily with the single layer of cells that line the intestinal tract. Intestinal epithelial cells have developed a number of strategies aimed at identifying microorganisms and eliciting the appropriate inflammatory response. The pathogen recognition mechanisms and the signaling and inflammatory events that ensue within the intestine are the focus of this review.

Từ khóa


Tài liệu tham khảo

10.4049/jimmunol.167.3.1609

10.1016/S0952-7915(02)00013-4

10.1136/gut.52.3.439

10.1016/S0002-9440(10)64360-X

10.1016/j.micinf.2004.01.012

10.4049/jimmunol.170.5.2274

10.1016/S1286-4579(01)01479-4

10.1038/nri1180

10.1172/JCI1339

10.4049/jimmunol.167.4.1882

10.1172/JCI119514

10.1084/jem.20022194

10.1046/j.1365-2567.1997.00326.x

10.1152/ajpcell.00507.2001

10.1074/jbc.M311821200

10.1242/jcs.01500

10.1016/j.tim.2004.02.009

10.1073/pnas.0400832101

10.1016/j.tim.2003.12.011

10.1053/j.gastro.2004.01.007

10.1007/978-1-4615-4861-4_12

10.1016/j.cell.2004.07.002

10.1073/pnas.241308598

10.1152/ajpgi.00299.2003

10.1146/annurev.immunol.21.120601.141126

10.1186/1471-2180-4-33

Wehkamp J, Harder J, Wehkamp K, Wehkamp-von Meissner B, Schlee M, Enders C, Sonnenborn U, Nuding S, Bengmark S, Fellermann K, Schröder JM, and Stange EF. NF-κB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium. Infect Immun 72: 5750–5758, 1999.

10.1152/ajpcell.00171.2004

10.1128/IAI.71.1.1-12.2003

Thông tin
Thông tin xuất bản

American Journal of Physiology - Gastrointestinal and Liver Physiology

Tập 288 Số 5

G854-G859

Thông tin tác giả