Evaluation of serological test of Zika in an endemic area of flavivirus in the Colombian Caribbean
Tóm tắt
The Zika virus (ZIKV) is an emerging flavivirus transmitted primarily through arthropods, endemic in Africa, Asia, and the Americas, and is considered a global threat by the World Health Organization. To evaluate a commercial Zika virus test (IgG/IgM catalog number B815C, Biocan, Canada. We evaluated 30 sera of patients diagnosed with Dengue, Leptospira, Malaria, Hantavirus, and Chikungunya. To establish the sensitivity of the test, two groups of sera were analyzed, the first one was patients with Zika RT-qPCR positive, and the second were patients RT-qPCR negative but with clinical suspicion of Zika. The specificity was of 23.3% (7/30), the sensitivity in acute patients with positive RT-qPCR was of 63.6%, the patients with clinical suspicion of Zika the sensitivity (IgM) was of 80% (n = 8/10). Overall sensitivity (IgM) of both groups was of 71.4% (15/21). The test showed a low specificity to be used as a serological test in an endemic area of flavivirus infection.
Tài liệu tham khảo
World Health Organization. Laboratory testing for Zika virus infection: interim guidance. WHO/ZIKV/LAB/16.1. Geneva: World Health Organization; 2016. http://apps.who.int/iris/bitstream/10665/204671/1/WHO_ZIKV_LAB_16.1_eng.pdf. Accessed 12 Mar 2018.
Rasmussen SA, Jamieson DJ, Honein MA, Petersen LR. Zika virus and birth defects—reviewing the evidence for causality. N Engl J Med. 2016;374(20):1981–7.
Rodriguez-Morales AJ, Villamil-Gomez WE, Franco-Paredes C. The arboviral burden of disease caused by co-circulation and co-infection of dengue, chikungunya and Zika in the Americas. Travel Med Infect Dis. 2016;14(3):177–9.
Alvis-Guzmán N, Zakzuk-Sierra J, Vargas-Moranth R, Alcocer-Olaciregui A, Parra-Padilla D. Dengue, Chikunguña y Zika en Colombia 2015–2016. Rev MVZ Cordoba. 2017:5994–6003.
Zhang B, Pinsky BA, Ananta JS, Zhao S, Arulkumar S, Wan H, et al. Diagnosis of Zika virus infection on a nanotechnology platform. Nat Med. 2017;23(5):548–50.
Mattar S, Tique V, Miranda J, Montes E, Garzon D. Undifferentiated tropical febrile illness in Cordoba, Colombia: not everything is dengue. J Infect Public Health. 2017;10(5):507–12.
Cuevas EL. Preliminary report of microcephaly potentially associated with Zika virus infection during pregnancy—Colombia, January–November 2016. MMWR Morb Mortal Wkly Rep. 2016;65:1409–13.
Mendez N, Oviedo-Pastrana M, Mattar S, Caicedo-Castro I, Arrieta G. Zika virus disease, microcephaly and Guillain-Barre syndrome in Colombia: epidemiological situation during 21 months of the Zika virus outbreak, 2015–2017. Arch Public Health. 2017;75:65.
Sarmiento-Ospina A, Vásquez-Serna H, Jimenez-Canizales CE, Villamil-Gómez WE, Rodriguez-Morales AJ. Zika virus associated deaths in Colombia. Lancet Infect Dis. 2016;16(5):523–4.
Mattar S, Ojeda C, Arboleda J, Arrieta G, Bosch I, Botia I, et al. Case report: microcephaly associated with Zika virus infection, Colombia. BMC Infect Dis. 2017;17(1):423.
Instituto Nacional de Salud. Comportamientos de los eventos de vigilancia en salud pública. Boletin epidemiológico 52 de 2016; Boletin epidemiológico 52 de 2017; Boletin epidemiológico 17 de 2018. 2014. https://www.ins.gov.co/buscador-eventos/Paginas/Vista-Boletin-Epidemilogico.aspx.
Mishra N, Caciula A, Price A, Thakkar R, Ng J, Chauhan LV, et al. Diagnosis of Zika virus infection by peptide array and enzyme-linked immunosorbent assay. mBio. 2018;9(2):e00095-18.
Eboigbodin KE, Brummer M, Ojalehto T, Hoser M. Rapid molecular diagnostic test for Zika virus with low demands on sample preparation and instrumentation. Diagn Microbiol Infect Dis. 2016;86(4):369–71.
Paul LM, Carlin ER, Jenkins MM, Tan AL, Barcellona CM, Nicholson CO, et al. Dengue virus antibodies enhance Zika virus infection. Clin Transl Immunol. 2016;5(12):e117.
Instituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública: Enfermedad por Virus Zika (version 02). 2017. https://www.ins.gov.co/buscador-eventos/Lineamientos/PRO%20Zika.pdf.
World Health Organization. Zika virus disease: interim case definitions. 2016. https://www.who.int/csr/disease/zika/case-definition/en/.
Wong SJ, Furuya A, Zou J, Xie X, Dupuis AP 2nd, Kramer LD, et al. A multiplex microsphere immunoassay for Zika virus diagnosis. EBioMedicine. 2017;16:136–40.
Jeong YE, Cha GW, Cho JE, Lee EJ, Jee Y, Lee WJ. Viral and serological kinetics in Zika virus-infected patients in South Korea. Virol J. 2017;14(1):70.
Huzly D, Hanselmann I, Schmidt-Chanasit J, Panning M. High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses. EuroSurveillance. 2016;21(16):30203.
Steinhagen K, Probst C, Radzimski C, Schmidt-Chanasit J, Emmerich P, van Esbroeck M, et al. Serodiagnosis of Zika virus (ZIKV) infections by a novel NS1-based ELISA devoid of cross-reactivity with dengue virus antibodies: a multicohort study of assay performance, 2015 to 2016. Eurosurveillance. 2016;21(50):30426.
Bosch I, De Puig H, Hiley M, Carré-Camps M, Perdomo-Celis F, Narváez CF, et al. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Sci Transl Med. 2017;9(409):eaan1589.