Evaluation of levocarnitine, lactulose, and combination therapy for the treatment of valproic acid-induced hyperammonemia in critically ill patients

Epilepsy Research - Tập 178 - Trang 106806 - 2021
Carli Nicholson1,2, Melissa Fowler1, Chanda Mullen1, Brittany Cunningham1
1Cleveland Clinic Akron General, 1 Akron General Avenue, Akron, OH 44307, United States
2Licking Memorial Health System, 1320 West Main Street, Newark, OH 43055, United States

Tài liệu tham khảo

Aires, 2011, New insights on the metabolism of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA, J. Hepatol., 55, 426, 10.1016/j.jhep.2010.11.031 Aiyer, 2016, Valproic acid induced hyperammonemia in a long time treated patient, Case Rep. Psychiatr., 2016 Baddour, 2018, Valproic acid-induced hyperammonemia: incidence, clinical significance, and treatment management, Ment. Health Clin., 8, 73, 10.9740/mhc.2018.03.073 Brown, 2018, Levocarnitine for valproate-induced hyperammonemia in the psychiatric setting: a case series and literature review, Ment. Health Clin., 8, 148, 10.9740/mhc.2018.05.148 Chopra, 2012, Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management, Gen. Hosp. Psychiatry, 34, 290, 10.1016/j.genhosppsych.2011.12.009 Clay, 2007, Hyperammonemia in the ICU, Chest., 132, 1368, 10.1378/chest.06-2940 Hospira, Inc : Depacon (valproate sodium) for intravenous injection, USP [package insert]. McPherson, KS, Hospira, Inc. Maldonado, 2017, L-carnitine supplementation to reverse a patient undergoing chronic valproic acid treatment: a case report, J. Int. Med. Res., 45, 1268, 10.1177/0300060517703278 Mock, 2012, Levocarnitine for valproic acid-induced hyperammonemic encephalopathy, Am. J. Health-Syst. Pharm., 69, 35, 10.2146/ajhp110049 Ohtani, 1982, Carnitine deficiency and hyperammonemia associated with valproic acid therapy, J. Pediatr., 101, 782, 10.1016/S0022-3476(82)80320-X Sousa, 2013, Valproic acid-induced hyperammonemic encephalopathy – a potentially fatal adverse drug reaction, Springerplus, 2, 13, 10.1186/2193-1801-2-13 Yamamoto, 2012, Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients, Epilepsy Res., 101, 202, 10.1016/j.eplepsyres.2012.04.001