Evaluation of hydrogels for bio‐printing applications

Journal of Biomedical Materials Research - Part A - Tập 101A Số 1 - Trang 272-284 - 2013
Sean V. Murphy1,2, Aleksander Skardal1,2, Anthony Atala2
1these authors contributed equally to this work
2Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA

Tóm tắt

AbstractIn the United States alone, there are approximately 500,000 burn injuries that require medical treatment every year. Limitations of current treatments necessitate the development of new methods that can be applied quicker, result in faster wound regeneration, and yield skin that is cosmetically similar to undamaged skin. The development of new hydrogel biomaterials and bioprinting deposition technologies has provided a platform to address this need. Herein we evaluated characteristics of twelve hydrogels to determine their suitability for bioprinting applications. We chose hydrogels that are either commercially available, or are commonly used for research purposes. We evaluated specific hydrogel properties relevant to bioprinting applications, specifically; gelation time, swelling or contraction, stability, biocompatibility and printability. Further, we described regulatory, commercial and financial aspects of each of the hydrogels. While many of the hydrogels screened may exhibit characteristics suitable for other applications, UV‐crosslinked Extracel, a hyaluronic acid‐based hydrogel, had many of the desired properties for our bioprinting application. Taken together with commercial availability, shelf life, potential for regulatory approval and ease of use, these materials hold the potential to be further developed into fast and effective wound healing treatments. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A:272–284, 2013.

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Tài liệu tham khảo

10.1002/adma.201003963

10.1016/j.copbio.2009.10.003

10.1097/BCR.0b013e31818cb046

Pitts SR, 2008, National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary, Natl Health Stat Report, 1

10.1016/j.burns.2011.06.005

10.1016/j.jpedsurg.2011.03.070

10.1016/j.burns.2011.07.010

10.1097/00003246-200910000-00021

10.1097/BCR.0b013e3181e4ca62

Lloyd EC, 2012, Outpatient burns: prevention and care, Am Fam Physician, 85, 25

YooJJ AtalaA BinderKW ZhaoW DiceD XuT.Delivery System. Office United States Patent & Trademark.12/986 812July 14 2011. Available at:http://appft1.uspto.gov/netacgi/nph‐Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=20110172611.PGNR.

10.1517/14712590903563352

10.1089/ten.2006.0175

10.1016/S0167-7799(03)00033-7

10.2217/17460751.3.1.93

10.1002/ar.a.10059

Jakab K, 2006, Three‐dimensional tissue constructs built by bioprinting, Biorheology, 43, 509

10.1002/bdrc.20109

10.1016/j.biomaterials.2009.06.034

10.1016/j.biomaterials.2010.04.045

10.1002/dvdy.21684

10.1073/pnas.0400164101

10.1002/adma.201001436

10.1089/ten.tea.2009.0798

F.D.A., 2008, EVOLENCE® Collagen Filler ‐ P070013

KCL, 2012, AlloDerm® Regenerative Tissue Matrix

F.D.A., 2008, INTEGRA MESHED BILAYER WOUND MATRIX ‐ K081635

2012, Corgel Biohydrogel (TS‐NaHy)

2007, Extracel™ Hydrogel

F.D.A., 2003, Restylane™ Injectable Gel‐P020023

F.D.A., 2010, CELOX PRO‐K093593

F.D.A., 2012, Hydrogel Wound Filler And 3M; Tegagel; Wound Filler With Gauze

F.D.A., 1998, Phytacare Alginate Hydrogel Wound Dressing ‐ K980132

F.D.A., 1990, Intrasite Gel (labeling Revision)‐K901878

F.D.A., 2009, DuraSeal Spine Sealant System‐P080013

10.1016/j.jconrel.2011.04.007

10.1097/01.BCR.0000124790.69026.3D

10.1039/C1CS15203C

10.1111/j.1524-475X.2009.00538.x

10.1021/bm200326g

10.1016/j.progpolymsci.2011.06.003

10.1007/s10856-008-3389-2

10.1016/j.actbio.2011.10.004

10.1002/bit.22361

10.1016/j.biomaterials.2005.11.015

10.1016/S0142-9612(00)00348-3

10.1016/0267-6605(92)90095-B

10.1186/1471-2482-11-15

10.2165/11207700-000000000-00000

10.1002/jbm.a.30831

10.1016/j.biomaterials.2003.08.014

10.1532/HSF98.20101003

10.1089/ten.tea.2007.0349

10.1016/j.biomaterials.2005.11.015

10.1002/jps.23170

10.1111/j.1467-789X.2005.00158.x

10.1016/0267-6605(94)90057-4

10.12968/jowc.2000.9.2.26338

10.1002/jbm.a.33232

10.1163/156856295X00814

10.1227/01.NEU.0000164384.05351.59

10.1016/j.clineuro.2011.07.009

10.1089/ten.tec.2007.0392

10.1088/1758-5082/2/1/014110

10.1016/0142-9612(87)90007-X

Hunt TK, 1979, Wound management and infection, J Trauma, 19, 890

10.1016/j.biomaterials.2011.07.013

10.1002/jbm.b.31857

10.1016/j.actbio.2011.07.028

10.1111/j.1524-4725.1993.tb00370.x

10.1097/00003086-199011000-00043

10.1089/ten.2006.12.2407

10.1016/j.fertnstert.2006.07.1532

10.1002/jor.20499

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Journal of Biomedical Materials Research - Part A

Tập 101A Số 1

272-284

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