Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis

Human Molecular Genetics - Tập 23 Số 14 - Trang 3883-3890 - 2014
Felix Stickel1, Stephan Buch2, Heinz Zoller3, R. Hultcrantz4, Sabina Gallati5, C.H. Österreicher6, Armin Finkenstedt3, Andreas Stadlmayr7, Elmar Aigner7, Enijad Sahinbegovic8, Christoph Sarrazin9, Clemens Schafmayer10, Felix Braun10, Wiebke Erhart11, Michael Nothnagel12, Markus M. Lerch13, Julia Mayerle13, Henry Völzke14, André Schaller5, Wolfgang Kratzer15, Bernhard O. Boehm16, Bence Sipos17, Mauro DʼAmato18, Leif Törkvist19, Per Stål4, Alexander Arlt11, André Franke20, Thomas Becker10, Michael Krawczak12, Jochen Zwerina21, Thomas Berg22, Holger Hinrichsen23, Elisabeth Krones24, Christian Dejaco24, Michael Straßer25, Christian Datz7, Jochen Hampe2
1Department of Visceral Surgery and Medicine and
21st Medical Department, University Hospital Dresden, Technical University Dresden, Dresden, Germany
3Department of Gastroenterology, University Hospital Innsbruck, Innsbruck, Austria
4Department of Gastroenterology and Hepatology, Karolinska University Hospital, Stockholm, Sweden
5Department of Human Genetics, University Hospital Berne, Berne, Switzerland.
6Department of Pharmacology, Medical University Vienna, Vienna, Austria.
7Department of Internal Medicine, Hospital Oberndorf/Salzburg, Austria
8Department of Internal Medicine III, University of Erlangen‐Nuremberg, Erlangen, Germany
9Department of Internal Medicine I, University Hospital Frankfurt, Frankfurt, Germany
10Department of General and Thoracic Surgery
11Department of Internal Medicine I
12Institute of Medical Informatics and Statistics and.
13Department of Internal Medicine A and.
14Institute of Community Medicine, University of Greifswald, Greifswald, Germany
15Department of Internal Medicine I and
16Division of Endocrinology and Diabetes, University of Ulm Medical Centre, Ulm, Germany
17Institute of Pathology, University Hospital Tübingen, Tübingen, Germany
18Department of Biosciences and Nutrition and.
19Department for Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
20Institute for Clinical Molecular Biology, University-Hospital Schleswig-Holstein, Kiel Campus, Germany.
211st Medical Department, Hanusch Hospital, Vienna, Austria
22Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany.
23Gastroenterology Center Kiel, Kiel, Germany.
24Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria and.
25First Department of Medicine, Paracelsus Private Medical University of Salzburg, Salzburg, Austria

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Tài liệu tham khảo

Soranzo, 2009, Nature genetics, 41, 1182, 10.1038/ng.467

2009, Atherosclerosis, 206, 228, 10.1016/j.atherosclerosis.2009.02.039

2009, Human Molecular Genetics, 18, 2711, 10.1093/hmg/ddp203

2010, Gastroenterology, 139, 393, 10.1053/j.gastro.2010.06.013

Beaton, 2006, Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 20, 257, 10.1155/2006/428048

Niederau, 1996, Gastroenterology, 110, 1107, 10.1053/gast.1996.v110.pm8613000

Milman, 2001, Annals of hematology, 80, 737, 10.1007/s002770100371

Feder, 1996, Nature genetics, 13, 399, 10.1038/ng0896-399

Jazwinska, 1996, Nature genetics, 14, 249, 10.1038/ng1196-249

Jouanolle, 1996, Nature genetics, 14, 251, 10.1038/ng1196-251

2010, Journal of hepatology, 53, 3, 10.1016/j.jhep.2010.03.001

Gleeson, 2004, European journal of gastroenterology & hepatology, 16, 859, 10.1097/00042737-200409000-00008

Powell, 2006, Archives of Internal Medicine, 166, 294, 10.1001/archinte.166.3.294

Beutler, 2002, Lancet, 359, 211, 10.1016/S0140-6736(02)07447-0

Allen, 2008, New England Journal of Medicine, 358, 221, 10.1056/NEJMoa073286

Bulaj, 2000, New England Journal of Medicine, 343, 1529, 10.1056/NEJM200011233432104

Benyamin, 2009, American journal of human genetics, 84, 60, 10.1016/j.ajhg.2008.11.011

Chambers, 2009, Nature genetics, 41, 1170, 10.1038/ng.462

Benyamin, 2009, Nature genetics, 41, 1173, 10.1038/ng.456

2011, Human Molecular Genetics, 20, 1042, 10.1093/hmg/ddq538

Camaschella, 2000, Nature genetics, 25, 14, 10.1038/75534

McLaren, 2011, 6, e17390, 10.1371/journal.pone.0017390

Sookoian, 2011, Hepatology (Baltimore, Md.), 53, 1883, 10.1002/hep.24283

Aleman, 2011, Scandinavian journal of gastroenterology, 46, 1118, 10.3109/00365521.2011.591426

Baumeister, 2008, Gastroenterology, 134, 85, 10.1053/j.gastro.2007.10.024

2011, International Journal of Epidemiology, 40, 294, 10.1093/ije/dyp394

Stickel, 2011, Hepatology (Baltimore, Md.), 53, 86, 10.1002/hep.24017

Bernstein, 2012, Nature; Physical Science (London), 489, 57, 10.1038/nature11247

Adams, 2005, New England Journal of Medicine, 352, 1769, 10.1056/NEJMoa041534

Seidah, 2012, Nature reviews. Drug discovery, 11, 367, 10.1038/nrd3699

2011, Journal of Biological Chemistry, 286, 2728, 10.1074/jbc.M110.192344

Lin, 2008, Blood cells, molecules & diseases, 40, 122, 10.1016/j.bcmd.2007.06.023

2008, Blood, 111, 924, 10.1182/blood-2007-07-100677

2013, Hepatology (Baltimore, Md.), 57, 2514, 10.1002/hep.26297

2013, Journal of Biological Chemistry, 288, 36610, 10.1074/jbc.M113.453183

Bridle, 2003, American Journal Of Pathology, 162, 1661, 10.1016/S0002-9440(10)64300-3

2012, Journal of hepatology, 57, 1319, 10.1016/j.jhep.2012.07.041

Adams, 2005, Lancet, 366, 269, 10.1016/S0140-6736(05)66384-2

Stickel, 2005, Archives of Internal Medicine, 165, 1835, 10.1001/archinte.165.16.1835

Osterreicher, 2005, Journal of hepatology, 42, 914, 10.1016/j.jhep.2005.01.023

Ishak, 1991, Alcoholism, clinical and experimental research, 15, 45, 10.1111/j.1530-0277.1991.tb00518.x

Hampe, 2001, Bioinformatics, 17, 654, 10.1093/bioinformatics/17.7.654

Franke, 2006, Human mutation, 27, 583, 10.1002/humu.20306

Dupont, 1998, Controlled clinical trials, 19, 589, 10.1016/S0197-2456(98)00037-3

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Human Molecular Genetics

Tập 23 Số 14

3883-3890

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